Question 1
Which of the following conditions would most likely increase the free drug concentration in plasma?
Question 2
Which drug has a very high volume of distribution (approximately 150,000L) and is used to treat malaria?
Question 3
What is the clinical significance of high protein binding in drug distribution?
Question 4
Why does phenytoin have a prolonged effect in the body?
Question 5
How does the solubility of a drug influence its distribution?
Question 6
Given a drug with a dose of 2,000 mg and a peak plasma concentration of 28.5, what is its volume of distribution?
Question 7
Which organs are known for having high blood flow, leading to higher potential drug distribution?
Question 8
Which type of capillaries are characterized by large intracellular clefts and pores, making them highly permeable?
Question 9
What influence does low protein binding have on drug distribution?
Question 10
High blood flow to which organs is clinically significant in terms of drug distribution?
Question 11
What capillary type typically exists in the brain and provides the blood-brain barrier (BBB)?
Question 12
What represents the theoretical volume in which a drug is distributed within the body?
Question 13
What happens to drug distribution in cases of septic shock?
Question 14
Which type of drugs are expected to have a high volume of distribution (Vd)?
Question 15
Which conditions can potentially lower drug distribution by reducing blood flow to tissues?