hi my name's amanda and i'm a pharmacist i'm continuing with my top 200 drug series today we'll be looking at part two blood thinners cholesterol and diabetes medications we'll be covering what the drugs are for their generic and brand names first we'll look at the anticoagulants these are known as blood thinners therefore the treatment of blood clots and the prevention of new clot formation these don't actually thin the blood what they do is interrupt the body's natural clotting process to prevent heart attack and stroke and there are some different mechanisms for doing this first is the vitamin k antagonist these block vitamin k which is involved in the clotting process an inconsistent dietary intake of vitamin k can interfere with their effectiveness and they require inr blood testing to make sure that the blood clotting is kept at a safe and effective level and we have in this class warfarin which the brand name is coumadin next we have direct oral anticoagulants or duax and in the top 200 we have two direct factor 10a inhibitors that are under this class now these are not affected by diet and they there is no inr blood testing required for their monitoring these end with the suffix a-band so there's apixaban which is eliquis and there's rivaroxaban which is xeralto next we'll look at the antiplatelets also known as platelet aggregation inhibitors these aren't technically anticoagulants because they don't affect the clotting process but they work by preventing platelets from sticking together to decrease the risk of heart attack or stroke with these you have aspirin the brand name is echotrine and clopidogrel which is plavix now we'll look at the cholesterol medications first is the hmg-coa reductase inhibitors these are known as statins they reduce the production of cholesterol made by the liver and these end with the suffix statin there's a torvastatin which is lipitor simvastatin which is zokor rasuvastatin which is crestor pravastatin which is pravachol and lovastatin which is mevacor or altoprev and there are a couple other cholesterol medications in the top 200. first we have ones that reduce cholesterol and triglyceride levels this includes pheno fibrate which is trachor and the omega-3 acid ethyl esters which is lavazza then there's also one that inhibits the intestinal absorption of dietary cholesterol this is a zetimab which is zedia next we have the diabetes medications these include ones that are taken by mouth and also injectables first is the sulfonylureas these are taken by mouth and they are the oldest diabetes medications available the way they work is by increasing insulin release from the beta cells of the pancreas there's glyphozod which is glucotrol and glimepiride which is amaryl next is the baguanides these are also taken by mouth they have a few mechanisms of action they reduce the amount of sugar produced by the liver reduce the amount of sugar absorbed in the intestines and increase insulin sensitivity and this includes metformin or glucophage next is the dpp4 inhibitors these are taken by mouth they slow the inactivation and degradation of glp-1 which is an incretin hormone that triggers insulin or release to lower blood sugar these end with the suffix glypton so there's lenoglipton which is tragenta cytoglyptin which is genuvia and then there's a combination product of metformin and and pseudoglypton which is genumet next is the tzd's these are taken by mouth and they're also known as the glitta zones they increase the sensitivity of cells to insulin or in other words decrease insulin resistance these end with the suffix glitazone and in the top 200 there's pioglitazone which is actos next is the sglt2 inhibitors these are taken by mouth and they're known as the glyphlosins they cause more glucose to be excreted into the urine instead of reabsorbed into the body and then the top two hundredth there's cannagliflozin which is invokana next is the glp-1 analogs these are injectables also known as incretin mimetics these work by mimicking the encretine hormone glp-1 which is produced in the gi tract after a meal causing an increased release of insulin from the pancreas and these end with the suffix glutide or atide and in the top 200 we have lyra lyroglutide which is victoza and doula glutide which is trulicity next we have the insulins these are all injectable they take the place of insulin that's normally produced by the body in order to move glucose out of the blood into the body tissues where it's used for energy there are different types of insulin there's rapid short intermediate and long acting and in the top 200 rapid and long acting insulins are there so we'll look first at the rapid acting insulin these have onset within 30 minutes and a duration of three to five hours there's insulin lispro which is humalog and insulin asphart which is novalog then there are the long acting insulins these onset within two hours and they have a duration up to 24 hours but with the deglodec insulin it has a duration that can be up to 45 hours so these in the top 200 include insulin glargine which is lantus or basilar and insulin detemir which is lavemere and insulin deglodec which is traceba that concludes part two so thanks for watching please like and share this video with others who may find it helpful and please subscribe to see more of my drug information videos and up next we'll be continuing our top 200 drug series with part 3 the gi medications thanks for watching