Huberman Lab Podcast Notes: NAD Pathway and Longevity with Dr. Peter Attia

Introduction

• Host: Andrew Huberman, Professor of Neurobiology and Ophthalmology at Stanford School of Medicine.
• Guest: Dr. Peter Attia, medical doctor and expert in healthspan and lifespan.
• Discussion focus: NAD pathway, its molecules, and potential in improving lifespan.

Key Topics Discussed

NAD Pathway Overview

• Importance of NAD: Significant role in energy production and multiple cellular processes (over 500 pathways use NAD as a cofactor).
• NAD Decline with Age: NAD levels decline with age, particularly in certain tissues like skin, which reportedly sees up to 60% reduction over a lifespan.

Molecules in the NAD Pathway

1. Nicotinamide Riboside (NR)
   • Converts directly to NAD.
   • Easier for cells to absorb.
2. Nicotinamide Mononucleotide (NMN)
   • Precursor to NAD but less readily absorbed due to presence of phosphate group.
3. Direct NAD Infusions
   • High cost; potentially uncomfortable (side effects include nausea).

Benefits and Limitations of NAD Supplementation

• Efficacy Debate:
  • Limited evidence supports NAD supplementation for lifespan extension.
  • No compelling studies showing improvements in healthspan or longevity from NAD, NMN, or NR supplementation in humans.
  • Positive anecdotal reports from users, but lack of solid scientific backing.
• Exercise and Lifestyle Over Supplements:
  • Emphasis on importance of physical exercise, proper nutrition, and cognitive health over reliance on supplements.

Framework for Approaches to Longevity

1. Behavioral Approaches
   • Movement (exercise), sleep, and nutrition.
2. Targeting Disease Processes
   • Utilizing specific drugs (e.g., Metformin, Rapa) to target chronic diseases.
3. Specific Cellular Pathways
   • Examination of NAD pathway as potential target.
4. General Health Maintenance
   • Preventing diseases and promoting overall well-being.

Supplement Regimens Discussed

• Shared Supplements:
  • Both hosts mention taking various supplements but emphasize they are not replacements for healthy lifestyles.
  • Commonly mentioned supplements include:
    • Omega-3 (EPA/DHA)
    • Vitamin D3
    • Methyl B12 and Folate
    • Creatine Monohydrate
    • Magnesium (various forms)
• Distinct Practices:
  • Dr. Attia mentions specific drugs (e.g., rapamycin).
  • Huberman discusses leanings towards AG1 nutrient supplement.

Conclusion

• Final Thoughts:
  • Both advocates for a comprehensive, holistic approach to health lasting longer through lifestyle choices rather than dependency on supplements.
  • Encourage further research into NAD pathways but currently advise skepticism about their supposed benefits for longevity.