Bupropion Overview - Lecture Notes

Introduction

• Bupropion is a medication used to treat depression and aid in smoking cessation.
• It is known by the brand name Wellbutrin, but often referenced as bupropion on exams like the NCLEX.
• Mnemonic: Bulletproof vest represents bupropion (Bulletproof = Bupropion).

Uses of Bupropion

• Treating Depression:
  • It's an atypical antidepressant.
  • Works by blocking serotonin, dopamine, and norepinephrine receptors.
• Smoking Cessation:
  • Mimics the effects of nicotine in the brain to minimize withdrawal effects.
  • Helps taper off smoking.

Mechanism and Class

• Bupropion is classified under atypical antidepressants.
• It affects neurotransmitter receptors: serotonin, dopamine, norepinephrine.

Risks and Monitoring

• Increased Risk of Suicidal Thoughts:
  • Initial use can increase suicide risk due to improved energy but not mood.
  • Important to monitor for worsening depression or unusual behavior.

Side Effects

• Seizures:
  • Major side effect, lowers the seizure threshold.
  • Higher doses increase seizure risk.
  • Patient Education:
    • Avoid alcohol (further lowers seizure threshold).
    • Do not crush or chew pills (increases absorption rate and seizure risk).

Recap

• Bupropion helps treat depression and smoking cessation.
• Monitor for suicidal thoughts and seizure risk.
• Avoid alcohol, crushing, or chewing the medication.

Conclusion

• Preparedness is key (symbolized by the bulletproof vest analogy).
• Understanding bupropion helps in exams.

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