hello and welcome to math simplified in this video we will talk about the kreb cycle krebs cycle is also known as the tricarboxylic acid cycle and it is a biochemical pathway that is used to generate energy to the oxidation of acetyl-coa it is also used for the synthesis of NADH and for the production of amino acids krebs cycle takes place in the mitochondria of the eukaryotes and the cytosol of the prokaryotes the first step involved is actually a preparatory step which begins with pyruvate pyruvate is derived through the glycolysis of glucose which is a six carbon compound and it is split into two molecules of pyruvate which is a three carbon compound the next step includes the oxidation of pyruvate into acetyl-coa by the enzyme pyruvate dehydrogenase complex and in this reaction a molecule of carbon dioxide and a molecule of NADH is generated the acetyl co a is a two carbon compound in the next step the acetyl co a combines with oxygen as it eight which is a four carbon compound to form citrate and hence the resulting molecule is a six carbon compound this reaction is catalyzed by the enzyme citrate synthase in the next step the citrate is isomerized in to isocitrate by the enzyme akan it is next the isocitrate is oxidized into alpha ketoglutarate by the enzyme isocitrate dehydrogenase and in this reaction a molecule of nad is reduced to NADH and a molecule of carbon dioxide is generated hence the alpha ketoglutarate is the five carbon compound since one molecule of carbon is lost into carbon dioxide next the alpha ketoglutarate is converted into sixteen alkyl by the enzyme alpha ketoglutarate dehydrogenase and in this reaction also a molecule of nad is reduced to NADH and a molecule of carbon dioxide is released hence the 16 algo a is the four carbon compound in the next step this sucks in Elko a is converted into succinate by the enzyme succinylcholine taste in this reaction a molecule of gtp is generated neck succinate is converted into fumarate by the enzyme succinate dehydrogenase in this reaction a molecule of qs2 is generated which is used for the production of fadh2 fumarate is then converted into malate by the enzyme fume race and in the last step the malate is converted into oxaloacetate by the enzyme malate dehydrogenase and in this reaction also nad is reduced to NADH now let's look at the results of the Krebs cycle through each cycle of the krebs cycle following products are generated three molecules of nadh one molecule of fadh2 one molecule of GTP and two molecules of carbon dioxide now since glucose is split into two pyruvate compounds for each molecule of glucose this cycle runs twice hence the products formed are six NADH two fadh2 to gtp and four carbon dioxide all the nadh and fadh2 are next fed to the electron transport chain for the generation of ATP so this was a short description of the krebs cycle thank you so much for watching this video make sure to subscribe us on YouTube for all the latest videos and also make sure to follow us on Facebook for the latest updates you can support massively fight by buying on any shopping website like flip card Amazon eBay Snapdeal and many other sites to the affiliate links given in the description below whatever you buy a small percentage of that will be donated to met simplified which is used for covering the cost of equipment softwares and maintenance of this channel you can also donate directly to met simplified all links are given in the description below