Question 1
What is the major enzyme that metabolizes approximately 50% of drugs?
Question 2
What is the main function of the CYP450 system during drug metabolism?
Question 3
What is the primary purpose of drug metabolism?
Question 4
What happens to the drug after absorption in oral administration?
Question 5
What effect does a CYP450 inducer have on drug metabolism?
Question 6
Which enzyme system is responsible for the majority of drug metabolism in the liver?
Question 7
What type of metabolizer would require higher doses of drugs due to genetic polymorphism?
Question 8
Where does the first pass metabolism primarily occur?
Question 9
Which phase two reaction makes a drug highly polar and water-soluble for excretion?
Question 10
How does liver disease affect CYP450 enzyme activity?
Question 11
What potential risk arises from the combination of clopidogrel and omeprazole?
Question 12
Which phase two enzyme reaction involves the addition of a sulfate group?
Question 13
Which phase of metabolism involves oxidation, reduction, and hydrolysis reactions?
Question 14
What is one consequence of genetic polymorphism in drug metabolism?
Question 15
In which structures within hepatocytes are CYP450 enzymes located?