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What evolutionary significance does the prion protein have?
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The prion protein is found across humans, mammals, and birds, suggesting an evolutionary purpose.
Why is FFI often misdiagnosed?
Symptoms like hallucinations can mislead diagnosis, suggesting conditions like schizophrenia.
What are possible consequences of the PRNP mutation leading to reduced awareness in sleep?
The thalamus fails to monitor sensory information effectively, disrupting sleep.
What conflicting roles have experiments in mice suggested for the prion protein?
Less prion protein may reduce long-term potentiation, while more could enhance synaptic transmission.
In what way could prion proteins protect neural tissue, based on experimental evidence?
Prion proteins could protect neural tissue from damage, as shown in stroke experiments.
Which part of the brain deteriorates due to Familial Fatal Insomnia?
The thalamus deteriorates, which is a relay center involved in sleep regulation.
What genetic mutation is responsible for Familial Fatal Insomnia?
FFI is caused by mutations in the PRNP gene.
What is the relationship between Familial Fatal Insomnia and Creutzfeldt-Jakob disease?
Both are prion diseases but affect different brain regions.
What is the typical age range for the onset of Familial Fatal Insomnia symptoms?
FFI typically affects adults in their 30s but can appear in teenagers.
How does the prion protein mutation lead to neural degeneration in FFI?
The prion protein mutation causes deterioration of the thalamus, leading to neural degeneration.
How long do patients usually survive after the appearance of symptoms in Familial Fatal Insomnia?
Patients usually die within 1-2 years after symptoms appear.
How might understanding prion proteins aid in Alzheimer's and multiple sclerosis research?
Insights from prion protein study could inform treatments for memory and brain aging issues.
What is a dreamlike perception while awake and which condition can it indicate in FFI?
It refers to experiencing dreams during the day and can indicate altered sleep cycles in FFI.
Why is further research into prion proteins critical according to the notes?
Further research could lead to treatments for FFI and other similar conditions.
What is a potential memory-related theory involving the prion protein?
The prion protein may play a role in long-term potentiation, which is critical for memory.
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