Top 200 Drugs Presentation: Part 10

Overview

• Presenter: Amanda, a pharmacist
• Topics Covered: Medications for Gout, Glaucoma, Dementia, and Parkinson's Disease
• Structure: Drug uses, pharmacology, mechanism of action, generic and brand names

Gout Medications

• Condition: Excess uric acid causing painful joint inflammation due to crystal deposits
• Medications:
  • Allopurinol
    • Brand Name: Zyloprim
    • Mechanism: Xanthine oxidase inhibitor
    • Use: Reduces uric acid production; used in prevention of gout
  • Colchicine
    • Brand Name: Colcrys
    • Mechanism: Tubulin disruptor
    • Use: Blocks inflammatory responses from uric acid; used for prevention and treatment of gout

Glaucoma Medications

• Condition: Increased eye pressure leading to potential optic nerve damage
• Goal: Lower eye pressure to prevent blindness
• Medication Classes and Examples:
  • Beta Blocker
    • Example: Timolol
    • Brand Name: Timoptic
  • Prostaglandin Analog
    • Example: Latanoprost
    • Brand Name: Xalatan
  • Alpha-2 Agonist
    • Example: Brimonidine
    • Brand Name: Alphagan P

Parkinson's Disease Medications

• Condition: Movement disorder due to decreased dopamine in basal ganglia
• Goal: Reduce symptoms like tremor and rigidity by increasing dopamine levels
• Medications:
  • Dopamine Precursor & Decarboxylase Inhibitor Combination
    • Example: Levodopa with Carbidopa
    • Brand Name: Sinemet
  • Dopamine Agonists
    • Examples:
      • Pramipexole
        • Brand Name: Mirapex
      • Ropinirole
        • Brand Name: Requip
    • Additional Use: Restless Leg Syndrome

Dementia Medications

• Condition: Loss of cognitive abilities affecting daily activities; Alzheimer’s is a main cause
• Goal: Improve mental function
• Medications:
  • Cholinesterase Inhibitors
    • Mechanism: Increases acetylcholine in the brain
    • Example: Donepezil
    • Brand Name: Aricept
  • NMDA Receptor Antagonist
    • Mechanism: Decreases glutamate and calcium, slowing brain cell damage
    • Example: Memantine
    • Brand Name: Namenda

Conclusion

• Thank you message and invitation to like, share, and subscribe
• Next video will cover hormones and supplements

Note: These notes summarize key points from a presentation on medications treating specific conditions such as gout, glaucoma, dementia, and Parkinson's disease, focusing on pharmacology and generic/brand names.