Transcript for:
Understanding Stem Cells for Longevity

you have looked into a guy in China who's reported to have lived for 250 years his name was Lee chinguen born in 1678 he passed in 1933 you believe it or you don't I can't say with 100% certainty and no one can well go back your grandfather 10 Generations ago and tell me if you can find their birth certificate at 250 years he offered the chair he refuses the chair he's sitting down on the floor with his back straight he was using a lot of plant trust nature more really your listening to the human upgrade with Dave asree today's episode is all about the innate repair system in your body because if you want to live for a very long time or you just want to recover faster from whatever you did last weekend you can change how your body recovers it'll either recover quickly or it'll recover slowly and there are different repair systems in the body so our episode today comes with a powerful expert who happens to be a black belt in Taekwondo amongst many other things his name is Christian dero he's been on the show before he's a friend founder and chief science officer of stem regen 20 years of studying stem cells and has a degree in neurophysiology and has scoured the planet looking for plant compounds that will activate stem cells the reason I'm so interested in this is that I do $50,000 stem cell procedures and most people aren't going to do that at least now and I recognize that so what can you do that activates and moves your stem cells around to the right places that doesn't break the bank and Christian in those 20 years figured out some ways to do that and it's stuff that I use it's stuff that I send to my parents uh so I found he's he knows a lot of core science I was exceptionally skeptical when I first met Christian he talked about what he did yeah right you 10 million stem cells um from taking a couple capsules I I don't believe it and we went really really deep on the science and he showed me what he was doing and how it worked I'm like wow this is one of those things that radically lowers costs so today we'll probably talk about some of those plant things but that's not the point of it the point of this today is for you to understand how your innate repair system works and the different things you can do to turn on healing and to turn on longevity and I think you're going to find he knows things that you won't typically hear anywhere else Christian welcome to the show my pleasure Dave thank you how does the innate repair system work just like you have an immune system nobody puts that in question everybody knows that you have an immune system in the exact same way you have a repair system so you get an injury let's let's make the comparison with the immune system you cut your yourself you have a bacteria that gets into your into that cut it will trigger the release of immune cells from your lymph nodes these immune cells will be attracted specifically to where you have a cut they will go there they will migrate beside the bacteria they will kill the bacteria this is very well-coordinated immune system your stem cells are exactly the same you get an injury it releases compounds that will go to the bone marrow trigger the release of stem cells from the bone marrow we can quantify an increase of up to tenfold in the number of stem cells after a significant injury then the affected area will release other compounds that will attract stem cells to that area stem cells will migrate into that tissue and upon contact with Cellar debris of that tissue stem cells will become cells of that tissue just so it's your repair system and I find I what I find fascinating in this is that every single human being on the planet without one exception have experienced that the body repairs everybody has had a cut a broken bone a bruise whatever every OBS observes that is witness to the fact that their body repairs and yet in medicine until stem cell research discovers the natural role of stem cells in the body we did not have an understanding I me nobody brought up the question how does the body actually repair you get a broken bone the doctor puts you in a cast says come back in six weeks we take off the cast there's no language about what do you do during those six weeks to help your body repair is because we did not have an understanding so that's the repair system we know that as you age your immune system becomes less effective and one of the things that's likely causing a substantial amount of Aging is inappropriate activation of immune response inflammation so this could be food allergies environmental allergies or even autoimmunity and that this tends to make you old and lower performing in the meantime what's the difference between activation or inappropriate activation of the immune system versus the innate repair system from stem cells in terms of stem cells the best answer that I can give you is that I'm not aware of a an actual like activation of stem cells that could be excess activation of stem cells we have two things that that work together one is the Aging of stem cells like they age just like any cells actually more than other cells because they divide so much in the body so you get improperly folded proteins and everything that comes from a very active cell uh accumulates in in in in the cell so a top and actually it's interesting to see that fasting that triggers autophagy uh some studies not enough has been done but from what has been done if you take a stem cell from the bone marrow and then you have the person and you test its ability to proliferate and migrate into a tissue and then you get that person do a three-day fast then you take another sample of their bone marrow the stem cells have rejuvenated during those three days so post fasting they will migrate more easily more effectively will multiply more effectively so there's some evidence to show that your stem cell age but you can rejuvenate them through a fast that's the first thing that happens to sort of modulate or modify the ability of urinate repair system to function in the body the other one is simply the fact that red Maru converts to fatty Maru as we age that happens very early in our lives by age 15 we've lost 50% of our overall red marrow in our 30s it reaches 90% so as a young adult in your 30s you start to realize one day you don't repair as well that's just because you don't have as many stem cells in circulation that is probably like the main difference that happens as we age it's a decline in the number of stem cells available to participate to tissue repair what can you do to have younger stem cells besides fasting I would say the only thing and it's not a great response is that you have stem cells in your body that do not multiply a lot so they then remain younger so these are fat adipose stem cells there's a new type of stem cells that are they're called Muse stem cells multi- multilineage you've had them great so these are stem cells that tend to remain extremely resistant to changes stress so they tend to remain young so they're they're young stem cells if you try to rejuvenate your own stem cells I mean at this point fasting is the only thing that I know do you know anything else it looks like senolytics can do the same thing senolytics I'm not aware of the role of I don't know if the RO of the role of senolytics have been studied in stem cells in other cells they will tend to basically eptos is the is the sort of the the Right End path of senolytics you make them disappear and you replace them and they're replaced by stem cells they are replaced by stem cells um in one of the protocols I've used um you use pharmaceutical analytics for a little while before drawing marrow cells so that you get rid of all of the older weaker cells and you get a younger cohort doesn't mean you reverse the age of the stem cells but you get ones that are as young and healthy as they can be and so I've got two billion marrow cells banked and I've had my fat stem cells banked for eight or 10 years now and for listeners if you get a chance to bank your stem cells it's a really good idea um however these are expensive procedures to do and I think it's worth it if you have lots of money and if you don't have lots of money the easiest thing to do is say well how do I make my body release stem cells like I'm young and you can do that with uh stem regen very briefly tell me how stem regen actually makes the body release more stem cells stem regen is made of plant extracts that have all been documented by quantifying the number of stem cells in the bloodstream using Floy ometry to put more stem cells in circulation within just a few hours of consumption and by the way it's the normal physiology of stem cells they don't stay in your blood very long they're released they go into tissues or they go back to the bone marrow so the fact that we find that the effect is short live it's almost like an indirect confirmation that what we're documenting is real physiology of stem cells the way that it's doing it uh the simplest way for me to to to to explain it is just like when you have fasting mimicking compounds let's call them injury mimicking compounds they trigger in your body the same kind of reaction that would happen if you have an injury and uh and suddenly that injury is calling for stem cells so it's the release we can pick up in the blood certain compounds like gcsf gmcsf stem cell Factor sdf-1 these are all compounds that modulate stem cell function in the body and these planes just happen to modulate the secretion of these of these compounds in your bloodstream so in a nutshell that's what we do okay makes sense to me you're causing the stem cells to get released more are you going to somehow negatively affect your body if you're causing it to reduce or to release more stem cells than it normally what are you going to run out I mean I I can answer this question from different angles number one which is to me like the most obvious how did we find those plants we found these plants by looking at plant that have been used historically like for centuries and have been historically associated with many different kinds of benefits because if you release stem cells they will go to the pancreas of the diabetic the heart of the heart patient the lung of the person with emphysema so you expect a broad variety of benefits I'm looking for those plants and these are the ones that we have now in stem regen so you look back and these have been used for centuries so if there if these plants or releasing stem cells has any impact negative impact on the body it would have been picked up in history so so that's that's the first way to say they're safe they've been used for a long time they're safe a second way to answer the question um athletes like Olympic athletes like intense athletes the people who will train every day for let's say a decade or more every time you have a a a very intense physical activity you release a lot of stem cells so are athletes running out of stem cells no they don't and the last the last angle to answer that question there's a study done I won't go to the detail of it because it gets complex but the answer is is is is is mind-blowing the question was if we do myo ablation like what you do in a in a cancer treatment leukemia treatment you kill all the bone marrow how many stem cells do you need inject to make sure that you can rebuild the bone marrow and the question was if you have only one stem cell but you know it's a stem cell is that enough and the study have shown that if you inject one stem cell you can completely in six weeks reconstitute the entire bone marrow in the blood system wow so so releasing 10 million out of your old bone marrow bank it's like you taking a bucket of water out out of the ocean and wondering if you're going to empty the ocean there's no impact stem cells are like little nanom machines it just takes a couple to self-replicate and rebuild your bone marrow so they're rapidly generating way way faster than something like the liver that can also regenerate totally and and there's a stimulus it depends what is needed uh they can they can replicate very fast Christian you and I are both interested in extreme longevity reports throughout history and it has to be throughout history because if you're trying to find people who've lived longer than 120 years it's historical I'm aware of a case that's well documented in India of a guy who lived 185 have a book about it downstairs and you have looked into a guy in China who's reported to live or to have lived for 250 years and yeah there's all kinds of detractors say that can happen because it didn't but let's assume that everyone on the planet isn't an idiot because they don't believe the same things you believe so we're just being curious about this what was the reported practice of this guy tell me about him so it's say fellow in China I think his name was uh Le Lee chinguen at least English pronunciation of of his name born in 17 uh sorry 1678 uh and I think he passed in 1933 uh and and the basically the challenge there like you just said it could not be true because nobody can live that long and if he's if it's true then show his birth certificate well go back your grandfather 10 Generations ago and tell me if you can find their birth certificate so looking back at the history and again like like the one that you mentioned in India tons of documentation and when he's asked what is the secret The Secret of his of his longevity there are three main things number one he was using a lot of plants and very interestingly he was using plants like like goji berry uh FTI faai and then RI mushroom all three were shown to support stem cells Goji berryi supports the migration of stem cells FTI released stem cells we did these studies years ago we even filed a patent on it so very interesting he was stimulating his stem cells second at 250 years when in a meeting he's offered a chair uh and he he refuses the chair he's sitting down on the floor with his back straight so he refused any you walked 30 miles on that day to go to that meeting you refused to get into a card pulled by horses so muscle act like activity physical activity all every day of his life uh in the third one he says have a lighe heart and that was his main comment have a light heart so don't worry about anything most of the way it makes me think of Mark Twain when he said I spend my entire life resolving problems that fortunately never happened so all the stress of the stuff that we make up in our own minds that R do not reflect reality at all just let it go so so anyway so that was is secrets to longevity I've always been intrigued by these reports of people living a long time and you you look in the Bible you look in any ancient religious text they talk about it all the time hundreds of years it could be that all of them are just crazy and lying or it could be that we believe some things that aren't true some of these texts also reference ancient cities and then oh look someone reads the text and goes and digs in the sand and what do you know there's a city there so I can't say with 100% certainty and no one can that all of these reports from around the world are real or false but I think there's a pattern that's worth paying attention to and funny enough this guy had a very specific protocol that was stem cell focused so I think they're a part of of living a very long life and certainly living healthy until you are going to die and and this's documentation of these like you go back to to the Biblical times I mean there's no verification there's absolutely nothing to verify you believe it or you don't um so let's say even if you put these aside and you go to places like the fell people like the fellow that you talk in India or this Chinese man there is a lot of reports at the time of his living like I think like every 50 years he got a certificate for his longevity well at 250 years it's a bunch of certificates that were that were confirmed so there's a lot of traces of of his existence during all that time so um even if we don't believe 256 let's say he lived a long time time at least 150 and in that way to me what is so powerful about these testimonials is that you can't achieve what you don't believe in so if you don't believe that you can live 200 years your mind is such that you cannot reach it so the moment that you see these these cases it kind of breaks your ceiling in beliefs and now the moment that you start to accept it and believe in it it gives the collectivity the ability of basically reaching these you know reaching greater longevity just by belief one of the things I do for that is when I celebrate my birthday I just do it in percentages of my minimum so I'm very serious about living to at least 180 and it's less about not dying it's more about living all the way as long as I choose and when I I look at the practice of doing that telling my body that it's a 29% duty cycle is a lot more effective than whatever dumb calendar age uh so I think that's part of that being light in the heart and just having a world view that says you're going to live a lot longer I mean that's one thing that all centenarians or super centin centenarians have is that they do not develop a disease until just a few months before passing so somewhere anything that can delay the onset of any disease or maintain the health that you have today is basically playing into this whole game of longevity and that's where stem cells become to me like such a central part of this old question beautiful one of the Mysteries of the body is that we have these micr capillaries and they're smaller in diameter than red blood cells so somehow we have this little straw and you're sucking a bowling ball through a straw and it cannot happen because of pressure you can't blow something through a straw that's bigger than it is how does that work and how does it affect stem cells well the red blood cells themselves are just about the size of capillary so so the real question comes with stem cells stem cells can be up to 20 Micron your capillaries will be about up to 12 microns so and when you think about the fact that stem cells are the repair system if they don't reach capillaries that that's the place where stem cells can leave the blood and go into tissues that's where the machinery for that migration exist so if stem cells cannot get into capillaries that area of the body deprived of proper microvasculature uh is deprived of repair and I think that this is one of the main thing of any kind of chronic issues is that it needs repair but stem cells don't have access to it because the The Chronic nature of the problem has basically rendered that microcirculation ineffective uh so and that's where we're talking about adding up a number of of of of uh how could I say strategies here to improve microvascular uh nines to digest fibrin so that it brings more entrainment if you go with a microscope and you you look at blood circulation and how cells get into these capillaries you see immediately that it's the entrainment and the force of the flow that really entrain these cells into small capillaries dilation with nitric oxide producers uh rebuilding the glycocalix that really supports the stem cells in their circulation so these are different things to do to basically allow stem cells to get access to the to you know everywhere in the body there's also the role of sunlight and infrared light we've finally figured out that there's exclusion Zone water and it's one of the things that propels cell biology and this comes from body heat or sunlight holding water up against cell membranes or any kind of fat if you were to blend some butter and MCT in your danger coffee it makes exclusions on water according to research from the University of Washington when you take some of the ingredients that are in stem regen that increase nitric oxide so now you've got a bigger pipe and we'll just say more lubrication because you got some sunlight or some inclusions on water from blending um fats into water and then all of a sudden that creates the transport system to get the stem cells through these tiny little pipes they can get where they need to go and that's why for a lot of people like well I did one thing that needed to work and you just got to think of it like baking bread okay when do you add the yeast to the flour how long does it need to sit what's the next step does it rise when do you bake it and there's people who will say I just wanted to take a shortcut so I just bought some yeast and I threw it in there and I baked it and they got a cracker not a loaf of bread cuz didn't have the recipe right so I feel like when I'm using Cen getting sunlight in the morning is a really good idea you know drinking some coffee with a little bit of butter or NCT Blended in uh it's going to help my body have more exclusions on water whole body vibration all these things they work together as part of the recipe of Performing better and healing faster are there any other lifestyle things that you recommend to use with stemen hot or yeah yeah and and but before I go there I just want to emphasize it what you're bringing up there is a super super important point that is kind of well talked about within the bio acing Community but not a whole lot outside which is stacking do more than one thing because the the direct offshoot the direct outcome of science is that you need to study one thing and remove all the other variables to prove that that thing is working but in your life you never do one thing outside of other things and it leads us leads the world to a large extent to do one thing you know to help an issue at least the medical system will look at it this way but in reality life is absolutely not like this so stacking stem cells but done microcirculations surface tension of water like these are all stuff that we need to add together so surface tension try to use restructured water huge difference in order to support circulation into you you try to push water into a micro vessel and if that water as a high surface tension it can literally bounce at one of these fork and not get into a capillary you reduce surface tension of Water by using something like restructured water and you maximize circulation like like the impact is amazing so that's one thing that we can add uh coal plunge is great uh pulse electromagnetic frequencies this is something that uh I started to really look into it actually not long ago it sounds like you've been to upgrade Labs there you go so you do that at upgrade lab there you go we've been doing it for 10 years now for people help to make pmf part of biohacking because it's so powerful so you started getting into it so you start to dig because I asked this as a qu as somebody was an expert in that field and I said is there a link between stem cells and pmf and he looked at me straight in the eyes and he says duh so so I started to dig in literature and I will go as far as to say that actually with the bulk of of literature on pmf it's probably actually the main mechanism of action pmf will support the migration of the circulation of stem cells in the tisue their migration into a tissue their proliferation into a tissue and their differentiation so far in the clinical trials their differentiation into tendon ligaments bone muscles so anything that is joint it the benefits that you get to a large extent come from leveraging the effect of stem cells so now you release stem cells and then you use pmf and you really boost the effect of what you've done with stemen I think there's a case for doing stemen and then going into upgrade labs and doing pm MF and certainly it's going to activate some cells it also creates something called BMP or bone morphogenic protein and it does this because of an effect called a pzo electric effect and what that means is when you create that strong magnetic field around the cells they make a little bit of electricity and that electricity likely attracts or interacts with stem cells so they go there I have stupidly high levels of bone density uh to the point that they had a hard time cutting through the bone during a bone surgery and the doctor was just flabbergast he's like I've never seen this before what are you doing like well I have lots of cells right I have upgrade Labs doing pmf I get lots of minerals and there's stem regen and of course I've done a lot of other super esoteric stem cell procedures in vibration you use vibration whole Vibra yeah introduce that to the bicking field as well uh at upgrade labs and in fact I used to make one back when I was at bulletproof so all these things they affect stem cells and they affect bones cuz stem cells right around inside the bones at least some of them do and you mentioned something that I think is super important it's pmf it doesn't have an effect specifically on stem cells So based on my training in neurophysiology or let's say knowledge in neurophysiology and it extends to any other cells in the body there's a difference of electrical potential difference at at a cell membrane that electrical difference potential difference is what the the cell will use to drive specific compounds in and out of the cells so for sugar for example yes insulin is needed but you need this difference of potential to then drive it's like it's like a waterfall that the cell builds and then utilize to bring in stuff if you don't have the difference of potential a cell is actually unable to function normally and it is really so every cell is a battery in a way and pmf actually gives that to the body so when a cell goes into that field it gets charge much more easily so it brings like I mean every single cell of your body needs that electrical potential that voltage difference potential to function normally so it so it's stem cells but it goes far 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things that can increase that is the type of minerals that are in danger coffee so you have those two things you're on your stem regen you do whole body vibration you just stack all this stuff together you're like what just happened something different than I expected I want to ask you about some of the things you're doing uh with stemen and by the way guys you stick around at the end of the show Christian's gifting you 20% off there must be some difference between the way a professional athlete would use stem cells and someone who's reversing aging would use stem cells or stem regen what's the difference in the strategy for using stem cells when you do recovery of course it's acute so you want to so you do a physical activity that has created microtraumas uh micr lesions and tendon ligaments and so on so right at that moment that tissue is signaling so you want to relase stem cells right away so if you do intense physical activity and you want to recover faster two stem regen capsules right after release right after or sport right after the physical activity two before you go to bed and you'll see the day after your recovery is very different just because you've tapped into your own repair system when you start to think about longevity and that is the part that to me of all of what we're talking about is really the most to me is the most I don't know was the right term I was going to say the most fascinating but it's the most like it's most important from from a from a society standpoint to me it's like the biggest discovery of our lifetime and it's to understand that the at the core fundamentally we develop age related disease we talked about earlier longevity what is common to centenarians is that they don't develop problems until few months before they pass so how do we develop age related problems it's because of that natural decline in the number of stem cells so what stem cell research has revealed is that we experience aging like an old fence in your backyard like every year it's older it's an it's in Decline every year but that's not how health is is happening or aging is happening so what stem cell research has revealed is that our health is like a bank account you put $110,000 in your bank account and for a long time you look at your bank account and it stays at 10,000 that's because you have as much expense as you have income and that that bank account is not static it's very Dynamic but it doesn't move but as you age you have more and more expenses more and more cellular loss and less and less income because you have less and less stem cells so suddenly your your bank account starts to shrink that's your health the day that you run out of money it's bankruptcy that's the disease so the point is that aging is the same it's a balance between your income in stem cells your expense in celles as we age wear and tear makes us lose more and more cells and the decline in number of stem cells makes us less and less capable of offsetting that setor loss so if you lose too many cells in your pancreas that's diabetes you lose too many cells in your heart it's hard disease you lose too many cells in your bang making dopamine that's Parkinson every single age related disease that is going to shorten your lifetime develops because you don't have enough stem cells so from a longevity standpoints all you want to do is every day just release stem cells more stem cells in your blood circulation to offset cellular loss and 10 million stem cells a day with with with stem regen is enough to allow your body think about it in the month it's 300 million stem cells if a if 100 million stem cell injection is like great for you think about 300 million that you release in a month just by taking stem region every day to me it's like the primary longevity strategy well compared to the cost of getting and pain of getting your stem cells taken out and there are benefits to doing that because you can introduce them to the right place and all that compared to that or just take a couple stem Regens and get a high dose of stem cells regularly I I think there's room for both and because it's so much more affordable to do stem regen I I think it's just a normal healthy part of a comprehensive longevity strategy it's still not as cheap as you know vitamin C or minerals or something thing it doesn't do the same thing no it doesn't and just for people listening you build your stack over time that do different things and maybe you say okay I know if I'm going to work out heavy or if I've been injured I want to do c regen so maybe only take it sometimes because that's more economical there's nothing wrong with doing any of those things so it's okay to space things out when you need to do we have evidence that the Mind actually controls your stem cells super interesting question no evidence that I know of however the machinery for this is all there what I mean by this is that if you inject gcsf in a mouse in an animal to which triggers the release of stem cells from the bone marrow and you do this after having injected blockers of noradrenaline you do not get Stem Cell release so neur adrenaline which is through which is comes from neurons from nerve terminals to your bone marrow neur adrenaline is essential for Stem Cell release now each stem cells every stem cells in your body as receptors for all the main neurotransmitters now we know that the blood vascular Trigg fine capillaries have nerve terminals tons of nerve terminals uh that's what you lose when you have neuropathy see so basically the whole Machinery is there to say your brain can affect the release of stem cells can affect their migration in the tissue where you want these stem cells to go and that is why I'm thinking I remember when I was a kid teenagers maybe in Montreal and I read that story of that that fellow who dove into a pool and uh he did not know that the pool did not have six feet of water so he basically snapped his neck so he was fully paralyzed and within about three years he completely regained all mobility and what he said is that he spent three years in his bed visualizing light and reconnection of his spinal cord and he regained mobility and always studied with me because in medicine there's no explanation for this and I'm just thinking right now well maybe maybe the mechanism of behind this is that you release stem cells using your mind and you can drive them where they need to go so the Machinery is there I'm not aware that it it has been scientifically documented I look at at things like that and there's so many cases of it jod spend is doing a lot of work on showing that the Mind does affect systems in the body and he'll be speaking at the biohacking conference in May in Austin and you'll be there as well speaking and I think there's convincing evidence of it I've it one of the things that we do know is that a baby when there's one cell that's been fertilized every cell has every Gene so how does the cell know what to do there's no instruction manual for what cell is going to become a liver versus a brain versus an eyeball and all of that so something has to be controlling it and it is almost certainly either an information field or a Quantum field so we have all these lowlevel effects and we know that stem cells in fact a lot of biochemistry runs on Quantum effects those microtubules little capillaries the way they're sucking stem cells through them is actually because of a Quantum effect around water so given that we know the mind is a Quantum system and yes I talked about the studies that prove that so if the body is a Quantum system and the mind can affect the quantum stuff that underlies reality very provably even though we can't see it I think there's a mechanism there as well but like we said those are hard to prove prove wouldn't surprise me if someday there's going to be some guy who can tell stem cells to spell words on a slide dish with his mind but until then we're going to have to say it looks like it could work that way there's no doubt in my mind that that what you just talked about has an effect on stem cells let me first start by saying from a purely physiological standpoint like you said every single cell has the full DNA but so so that means the hard cell that is different from a liver cell that is different from a skin cell they all have the same DNA it's just different parts of the DNA that have been turned on so when a stem cell gets into a tissue let's say the liver and it's in in it's in the in the in the community if you want of other liver cells there are specific molecules that are that are unique to these different tissues albumin for example in the liver so I think that to a large extent it's these protein that are specific for a tissue that will tag a receptor the surface of the stem cells send a signal to the nucleus and now it will activate all the part of the nucleus that will make that cell now transform into a liver cell so there's a there's a good physiological process that has been documented into into the transformation of a stem cell what is to me more part of the quantum part that you just talked about is that it's one thing to have a stem cell transform into a liver cell or into a skin cell it's a completely other thing to say these cells now will develop into the complete infrastructure and ultr structure of that organ it's not just becoming a heaty or or a pancreatic cells it's to make these pancreatic cells develop fully into like full eyelets of Langer H all organized spatially uh into the different type of cells to make the whole part of of that body function completely normally it's not a it's a stem cell getting into the brain becoming a neurons supported by gal cells supporting by capillaries the whole tissue what makes stem cells develop all the ultra structure of that tissue there's no science for that this is like mind-blowing like your skin like your fingerprints you burn your fingerprints your skin repairs with stem cells and you still have all the fingerprints as you had them before how do you do that wait a minute I'm going to put on my petera hat there's no science for that therefore it doesn't happen Christian what are you thinking about it's unscientific I mean what you're saying is funny because we need to understand it is the S science tells you what you cannot quantify and document therefore is not true and is not real and to me and I like that approach in as much as it allows us to probe reality in a strong way not to assume that what you can probe is reality and it's all it is that is actually falling onto the dumb side of things because like what is the greatest force in all in nature with all of us human is it not love show me the love meter that allows to quantifying it I think it's actually the stubbornness of a 2-year-old that's that's but how can you measure stubbornness of a 2-year-old there's no machine so therefore it does not exist I think we have to kind of grow Beyond like it's it's a nice approach it's a little childish the role of science is to tell us a story that's useful for understanding and predicting reality and we know because of science that all of the reality we perceive is not actually reality which is very frustrating and even time I mean I sign it everyone else there but that's kind of a myth we just believe in it so what science does is it tells us these great stories like oh because of this I can predict this and it happens almost all the time and because of science when it's working correctly it means it works almost all the time but there are times when something else happen we go wait that's possible and then we zoom in on the outliers the ones that don't happen most of the time to figure out the mechanisms and to give ourselves a better story and people say well I believe in science or science-backed advice and people who don't agree with me are not scientific they're just bullies or sad people because the reality is the things that no one understands is where all the Innovation happens and it is science to look at those things and it is science to look at our story and say that's sure is useful but it isn't accurate and this is why I've had Nim on the show who beat the standard model by something like 6% he's a ski instructor so they're like that's not possible well as actually it is and this is why you look at what the difference between Newtonian physics which is a great story it's not science it just isn't science because it doesn't describe reality it's a part of science it's a useful story and now I'm going to piss off all the scientists there we used to have a story that it was fairies and leprechauns that did it and that was the most useful story we could make at the time and our stories get Tighter and Tighter and I believe every single thing we believe as scientists and I come from a scientific family I am a Scientist every single thing we believe is a story about reality that we will change as we learn more which means it's not fully correct it's just directionally accurate unless it's just not and that's true is confusing and it requires you to take a deep breath and if your entire life's work like let's say you're someone who believes you can't extend life and that the only thing you can do is OV exercise every day okay if you've been saying this and getting paid a quarter million dollars a year to say this for a while you will never change your mind because that's going to be a lot of crow to eat and this is why we see big pharmaceutical companies who will tell you do statens do stats yes they make money but if they admit they were wrong they have liability for all the they've been pedaling so your job one of the reasons I I like it is like how does it work what are the things we don't know is there a way to to push on this lever is there another way to do that and that Natural Curiosity comes from somewhere does curiosity come from stem cells uh I don't know we'll have to do a study on that a scientific study on that uh but I don't think so but it's a good thing I agree with what you're saying you know I I think the flaw is to assume or believe that Science Show shows you reality when science just allows you to poke and investigate it science the reality is beyond science science is really what can be Quantified there are many things in reality that cannot be Quantified and we can touch them we can experience them through science but to say that everything is limited to what we can quantify to me there are some like blatant uh aspects of science for example we don't have to dive into this but reincarnation in past lives science cifically if your proof is that somebody will come back and will show you that they were the other person um then that will be the proof it may never happen and yet there's tons of evidence tons and tons and tons of evidence that it's reality that can probably never be grasped by science if you want to approach it in a very very stringent and rigid manner so science rigid science that only consider what can be Quantified leaves out a whole portion of reality when science can Define what Consciousness is um then we're getting somewhere and until then I think there's a lot of of comforting ourselves with science and science is such a powerful force for figuring out how systems in the body work it's fantastic it doesn't mean it's real it doesn't mean it's true it means it's useful and it's directionally accurate and there's always another layer and finding those new layers is what I think is going to unlock our longevity and a big part of this is you the quantum nature of microtubules how stem cells know where to go in the body how do we direct them with our Consciousness all of these are TBD in science but to say none of those are real because they can't be real is the height of hubris quantum physics will change all is changing all of that I to say will change already if you dive in what we know of quantum physics it changes all of that already yeah it's pretty ungrounding one of the things that's been f fasinating me since my big longevity book a few years ago is looking at biological clocks and David Sinclair who's been on the show a couple times just saw him at the American Academy of an aging medicine where we both spoke he was the first guy to say we can reverse cellular aging and I'm interested in doing that and I've done a lot of protocols for that there's also some work I've done at RMI because can go to Dave ase.com RMI for that episode and there we were reversing the central aging clock in the brain it's a very expensive procedure but there's also a liver clock and there's a skin clock I want to know do stem cells have their own biological clock that we can reverse or do they step into a part of the body and then join that that clock system in that part of the body I think of what we know today I would say that it's probably what it is so stem cells will become cells of another tissue and then and then will adopt in the clock of that organ this being said we already know like I we talked about before fasting rejuvenate your stem cell so if you measure stem cell function in terms of their ability to proliferate migrate uh transform into different types of other cells if you quantify that and you determine that as being their biological age like like they behave like your stem cells 10 years ago fasting right now achieved that so stem cells stem cells have a biological clock like any other cell but there isn't a central stem cell clock that we're aware of that I'm aware of at this point I would not be surprised that that that becomes identified it's probably in the brain wouldn't surprise me I mean if you talk about a clock technically you talk about the time when a cell lose its ability to be immortal you know in if I if I push this to the extreme stem cells is your are Immortal in your body uh so they will multiply during the entire life of an individual until such time as they become too clogged with their own sailor Division and they have too many debris and they're like they're not really effective so if fasting allows to reverse that that's probably your your your clock in in a stem cell most of the regenerative techniques that are in superhuman my longevity book are around extracellular debris intracellular debris stiffening of cells mitochondrial function and tares membrane are all of those relevant to stem cells absolutely so so if you're going to reverse your age systemically including skin cells and all the other cells in the body then you might as well with those same techniques do the same things for your marrow and for your stem cells and I believe that's a systemic effect because of all the stuff I've seen about it m which is really powerful because the practices of longevity also give you younger stem cells and that's really powerful as long as you can mobilize and release them yeah I think I think one of those that that are not talk talked enough about although I think I've heard you talk about it which is the health of the membrane lipids that are in the membrane every sing we talk about electricity before the building of this voltage difference between the inside and the outside of a cell well the ability of a stem of a cell to maintain that voltage difference depends on the health of the membrane which depends on the actual constitution of that lipid membrane so all the lipids that we take by mouth as a huge impact on what is going to be the cell membrane of these the the membrane of these cells which drives basically the the the physiology of every single cell in the body so all this emergence of cell membrane replacement that kind of stuff I think this will play a huge role in longevity science and in the in the near future it is going to play a huge role in longevity science the other thing I'm really interested in how soon are we going to be able to hack our stem cells with Cris or Gene editing or some other technology to tell them to do something better or younger or to give us superpowers I mean right now and this may be a limited statement right now I would say I would probably trust nature more than try to start to act the genes nature is mean she wants you to die get out of the way and what I mean by this is that there's a reason why for example you're abilities of stem cells to to multiply kind of declines with age because if they're not controlled that's cancer wa we're we're not trusting nature when we take stem regen we're telling nature you're not giving enough stem cells like seriously you're making me age because you're not making my marrow do it what I want so I'm going to step in I'm going to send the signal in but I'm not changing the code of these cells I'm leveraging natural phenomenon in the body and as long as we do this I think that that it's a you know know it's safe it it's definitely lower risk definitely but maybe it's lower returns could be if you could edit your own stem cells to do anything you wanted and it was safe what would you do I mean I think it becomes a personal question what I mean by this is that you need to go and really find what is weak in your genetics and then take stem cells do that change in the Genome of that stem cells multiply that stem cells into a population and then Reed your bone marrow with these stem cells that is probably going to be a future application of stem cells planning on doing it relatively soon relatively soon because all the stem cells now that you have in your bone marrow have corrected that Gene but you've not affected the immortality of that Gene of of that of that cell that's where I'm I I don't know if it's right or wrong but that's where I'm thinking there's a natural process that Limits The Power of these stem cells as we grow and it could be a protection against cancer or different aberration so that's the part of nature that I'm just cautious of of trying to stimulate too much which is different than what you're talking about when you use crisper we don't change the immortali of these cells we just change the nature of these cells by by basically correcting weakness that you could have in your genome it's definitely a place where stem cell research is going that is that is super cool I'm interested in editing my mitochondria I'm interested in editing my stem cells to be plop poent so that they can do whatever I want them to do and I think we're right on the cusp of this it's already done you go to like you mentioned MRI RMI before and they're they're doing that kind of work you taking taking of stem cells uh inducing cloog genes which has been associated with longevity and starting to do these kinds of manipulation done in humans as you know I'm going down there next month there you go um I mean I'm extremely curious about it I'm not sure if I would do that quite today but yeah some someone has to now let me ask you this do you think it's possible to enhance and extend what you're doing with stem regen so that it causes stem cells to not just get released and move around but to do something new they haven't done before let me answer maybe indirectly but there's a video that I show when I give presentations just really like really shock the minds about the raw power of stem cells so it's a it's a the heart of a mouse that has been removed from the animal then in the lab they circulate proteolytic enzymes on the cardiac muscle so after about 12 hours they're left with the entire heart is completely digested all that you're left with is the soft skeleton of the heart like the connective tissue of the heart and on that connective tissue that still retains the trace that it was a heart heart they lay out the stem cells extracted from that same animal before within a week you get a beating heart in the test tube crazy so your stem cells can entirely rebuild the heart that's mindboggling so to me the question is not so much can I make my stem cells more effective it's more how can I unleash the raw regenerative power that they have what is it in the body that limits the full expression of that regenerative potential and that's why we came out with products like mobilize that opens the microvascular one of the reason is my stem cells do they reach that tissue another one is systemic inflammation systemic inflammation will activate stem cells in their ability to migrate outside of the area where you have the injury so so you messed you mess up these stem cells and their ability to really find where to go and do their job where they need to do it so these are two things that have been cleared out you know from from from the path in terms of the their ability and I'm sure there are other things but the idea is like how can we maximize their potential cuz they have it I don't think we need to trick them or really magnify their ability more than what they can do in their raw potential shown in that study it's true one of the things in biohacking that I I've said for a long time is I believe we should maximize the potential of our own Hardware before we replace it this is why I'm not a fan of replacing my eyeballs with cameras or something uh some of the transhumanism stuff it seems like we're not paying attention to what biology can do and I'd rather just use my existing Hardware or I'd rather say get a gene from the Axel which is the logo for upgrade labs this is a saler that can regenerate any part of its body over andever I'd rather do that and sure if I need robotic legs at some point in my life okay but that would be my last thing after I really went deep on what I what my neate biology can do can I just grow new legs using my stem cells or do I have to change the stem cells something weird it's it's coming and it's coming so fast it's super cool Christian you're doing some really cutting edge work and I love the way you think about the we'll say the spirituality of of stem cells and extreme longevity and the very practical approach of saying well let's look at all the plants that can release stem cells and the idea that for a little bit more than $100 you can have 300 million stem cells that you otherwise wouldn't have which unlocks stem cells for a whole swwa of people who aren't going to go spend you know $10,000 and leave the US and the people who are doing random umbilical cells within the US I think there's a lot of risk there that I've seen from multiple people so I don't recommend doing that so your options are stay in the US take stem regen by the way guys stem ren. cdve for the 20% off but you can do that you can go South of the Border and you can do some really creative stuff but it starts having a lot of zeros on the price tag so if everyone's going to get stem cells especially after a heart attack after an injury you know after even just a rough weekend a sren is really the only cost effective way that I found it or to do that so thanks for making it and thanks for coming back on the show thank you and by the way you're mentioning you know releasing your own stem cells versus stem cell injection without getting in there just some results now on a on a preliminary study that not preliminary it's a going study but we have a preliminary report that we just filed about three weeks uh 3 four weeks ago in the peer review scientific literature so it's accepted not for publication but for review so we'll be able to say more about this later but essentially on 10 people with chronic stable congestive art failure so people who have been treated by medicine with everything that medicine can do and for at least two years were in that condition where let's say they walk one flight of stairs then they need a chair to to to sit and and let's say recover their breath for like 5 10 minutes uh so we take these people we put them on stem regen and 6 months later 10 out of 10 have normal heart function so it's just to show here the point is not to say the product helps you recover from heart disease the point is just to show that all the problems that people have in their 50s 60s 7s they did not have them when they were 20 and 30 it's true because they had plenty of stem cells to offset any kind of cellular loss and when you don't have these stem cells the the problem slowly develops so all we do is that we give back to the body its own native ability to repair as you did you know 10 20 years ago when none of these problems were there that's the leverage that we're really creating that it's so impressive and I do want to say as we we wind up the show you're kind enough to send my parents a bunch of C regen and they've been on it for I think probably about six months now and they're both substantially better uh than than they were before and as just say well we're not really sure what it was but could you send some more so uh I I did notice a meaningful Improvement so thank you for your generosity there and um my parents have a lot going on so that's uh one of those things that says it there's a systemic effect it's not just one thing it's everything that requires repair of inflammation and old damage and aging thanks again guys stem ren. cdve see you next time on the human upgrade podcast