Estrogen Metabolism Webinar Notes

Welcome and Introduction

• Speaker: Dr. Hillary Miller, clinical educator at Precision Analytical
• Host: Noah Reed, VP of Sales and Marketing for Precision Analytical
• Topic: Estrogen metabolism, often misunderstood in hormonal health
• Importance: Estrogen's impact on women's health concerns like endometriosis and breast cancer
• Focus: Practical guide on Phase 1 and Phase 2 pathways, key players like P450 and methylation enzymes
• Invitation: Sign up as a registered provider for additional resources and education on Dutch testing

Key Points of the Webinar

Estrogen and Its Role

• What is Estrogen?: A female reproductive hormone present in all stages of life, impacting various body systems
• Health Impacts: Positive Effects: Skin, bone density, cognition, cardiovascular health, etc.
• Health Impacts: Negative Effects: Breast cancer, endometriosis, uterine fibroids
• Estrogen Metabolism: Important for mitigating risk factors related to estrogen and its metabolites

Risk Factors for Breast Cancer

• Statistics in the US: 1 in 8 women will face a breast cancer diagnosis
• Non-Modifiable Risk Factors: Age, gender, family history, genetics, ethnicity
• Modifiable Risk Factors: Smoking, alcohol, BMI, HRT, environmental chemicals, low vitamin D, lack of exercise, not breastfeeding before 35
• Role of Estrogen Metabolism: Affects risk factors, potential to reduce risk through proper metabolism

Estrogen Testing

• Methods: Serum tests, Dutch urine testing, cycle mapping
• Parent Estrogens: Estrone and estradiol, important to know their appropriate reference ranges

Estrogen Metabolism Pathways

• Phase 1 Pathways: Involved in deactivating estrogens, significant oxidative potential varies among metabolites
  • 2-Hydroxy Pathway (Happy Pathway): Anti-carcinogenic, stable, rapid methylation
  • 4-Hydroxy Pathway: Genotoxic, oxidative, binds to DNA
  • 16-Hydroxy Pathway: Estrogenic, pro-inflammatory, proliferative

Phase 2 Metabolism

• Methylation & Conjugation: Neutralizes oxidative potential of Phase 1 metabolites, increases water solubility
• COMT Enzyme: Key in methylating catechol estrogens and reducing oxidative damage

Influences and Interventions

• Improving Estrogen Metabolism: Cruciferous vegetables, green tea, fish oil, ground flaxseed, soy
• Antioxidants: Important to minimize oxidative potential of estrogen metabolites

Clinical Case Studies

• Case Examples: Used to illustrate different estrogen metabolism profiles and intervention strategies
• Typical Interventions: Use of DIM, antioxidants, and lifestyle changes to improve estrogen metabolism

Summary

• Estrogen's Dual Nature: Both beneficial and risk-bearing
• Phase 1 and Phase 2: Essential for regulating estrogen levels, minimizing negative impacts
• Testing and Ratios: Important for diagnosing and treating estrogen-related disorders

Questions and Further Resources

• Q&A: Unfortunately not enough time for questions
• Follow-Up: Follow on Instagram @DutchTest for more information and submit questions
• Additional Resources: Watch inboxes for recording link and access to shared resources
• Become a Provider: Visit DutchTest.com to register and gain more educational resources