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Comprehensive AP Biology Study Guide

May 5, 2025

Mr. W's AP Biology Exam Preparation Guide

Study Plan

  • Prioritize study topics using the stoplight method:
    • Red: Topics you don't know at all.
    • Yellow: Topics you know a little about.
    • Green: Topics you know well.
  • Study order: Red → Yellow → Green.
  • Resources for study:
    • Learn-biology.com tutorials and comprehensive reviews.
    • Science Music Videos unit and topic reviews.
    • Live Reviews scheduled by Mr. W.

AP Bio Unit 1: Chemistry of Life

  • Water and Hydrogen Bonding
    • Water's properties: cohesion, adhesion, surface tension, high specific heat.
    • Hydrogen bonding in DNA, RNA, proteins.
  • Elements and Molecules of Life
    • Formation of polymers via dehydration synthesis.
    • Breakdown of polymers via hydrolysis.
    • Carbohydrates: monosaccharides (energy storage), disaccharides (energy transport), polysaccharides (starch, cellulose).
    • Lipids: non-polar, fatty acids, energy storage, waterproofing, membrane formation, signaling.
    • Proteins: diverse functions, composed of amino acids, four levels of structure.
    • Nucleic acids: DNA/RNA, heredity molecules, nucleotide base differences.

AP Bio Unit 2: Cell Structure and Function

  • Cell Types
    • Prokaryotic vs. Eukaryotic: size, structure, DNA packaging.
  • Cell Size and Surface Area
    • Small size maximizes surface area to volume ratio for diffusion.
    • Adaptations to increase surface area (e.g., gills, elephant ears).
  • Membrane Structure and Function
    • Selective permeability, fluid mosaic model.
    • Membrane transport: diffusion, facilitated diffusion, active transport, bulk transport.
    • Osmosis and water potential.
  • Cellular Compartmentalization
    • Importance of internal compartments (e.g., mitochondria, chloroplasts).
    • Endosymbiotic theory: mitochondria and chloroplasts as ancient symbiotes.

AP Bio Unit 3: Cellular Energetics

  • Enzymes
    • Protein catalysts, lower activation energy, specificity, inhibition (competitive and non-competitive).
  • Cell Energy
    • Metabolic pathways: glycolysis, Krebs cycle, Calvin cycle.
    • ATP as energy currency, coupling reactions.
  • Photosynthesis
    • Light reactions: ATP and NADPH production.
    • Calvin cycle: carbon fixation, energy investment, regeneration of RuBP.
  • Cellular Respiration
    • Stages: glycolysis, link reaction, Krebs cycle, electron transport chain.
    • Aerobic vs. anaerobic respiration, fermentation process.

AP Bio Unit 4: Cell Communication and Cycle

  • Cell Communication
    • Signal reception, transduction, response.
    • Types of receptors and signaling pathways.
  • Homeostasis and Feedback
    • Positive and negative feedback mechanisms.
    • Examples: glucose homeostasis, childbirth.
  • Cell Cycle and Regulation
    • Phases of mitosis, checkpoints, cancer causes.

AP Bio Unit 5: Heredity

  • Meiosis and Sexual Reproduction
    • Creation of haploid gametes, genetic diversity.
  • Genetics
    • Mendelian concepts, alleles, phenotype vs. genotype.
    • Monohybrid and dihybrid crosses, sex-linked genes.

AP Bio Unit 6: Gene Expression

  • DNA and RNA Structure
    • Semiconservative replication.
  • Transcription and Translation
    • Protein synthesis process.
  • Gene Regulation
    • Eukaryotic vs. prokaryotic gene regulation.
    • Epigenetics: acetylation, methylation.
  • Genetic Engineering and Biotechnology
    • Techniques: PCR, gel electrophoresis, genetic modification.

AP Bio Unit 7: Evolution

  • Natural Selection
    • Adaptations, sexual selection, effects on populations.
  • Population Genetics
    • Hardy-Weinberg equilibrium, factors causing evolution.
  • Speciation and Extinction
    • Mechanisms of speciation, mass extinctions.
  • Origin of Life
    • RNA world hypothesis, protocells.

AP Bio Unit 8: Ecology

  • Responses to Environment
    • Case studies and analytical skills.
  • Energy Flow and Ecosystems
    • Trophic levels, energy pyramids.
  • Population Growth and Interactions
    • Models of growth, species interactions, keystone species.
  • Human Impacts on Biodiversity
    • Habitat destruction, invasive species, extinction vortex.

For more detailed resources and guides, visit learn-biology.com and participate in live review sessions with Mr. W.