Tetracyclines: Mnemonics and Key Facts

In this lecture, we explore the key aspects of tetracyclines, a class of broad-spectrum antibiotics, using memorable symbols and mnemonics to aid in learning.

Introduction to Tetracyclines

• Symbol: Red shiny bicycle
  • Tetracycline and bicycle both contain "cycle".
  • Tetra means four, symbolized by the bicycle's training wheels.
• Common Drugs: End in -cyclene
  • Examples: Doxycycline, Minocycline

Mechanism and Usage

• Antibiotic Symbol: Hand sanitizer
  • Tetracyclines kill bacteria (not viruses or fungi).
• Type: Broad-spectrum antibiotic
  • Effective against a wide variety of bacterial infections.

Side Effects

• Photosensitivity
  • Symbolized by boy's sunburn.
  • Patients should use sunblock and avoid direct sunlight.
• Tooth Discoloration
  • Symbolized by dirty teeth.
  • Causes permanent discoloration (gray/brown) in children.
  • Avoid in children and pregnant women due to fetal effects.

Interactions and Contraindications

• Avoidance with Milk and Antacids
  • Symbols: Glass of milk and a bottle of Tums (antacids).
  • Calcium and antacids prevent drug absorption.
• Teratogenicity
  • Symbolized by a tarantula on the bicycle tire.
  • Tetracyclines are toxic to the fetus, affecting tooth development and bone mineralization.
  • Should not be used during pregnancy.

Summary

• Recognition: Drugs ending in -cyclene.
• Use: Broad-spectrum antibiotic for bacterial infections.
• Side Effects:
  • Photosensitivity – use sunblock.
  • Tooth discoloration – avoid in children.
• Interactions:
  • No milk or antacids due to absorption issues.
• Pregnancy:
  • Teratogenic – avoid in pregnant women.

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