Lecture on Nitric Oxide: Its Role in Health and Disease
Introduction
The presentation covers the significance of nitric oxide in health, particularly its impact on conditions like Alzheimer's.
Dr. Nathan Bryan, a biochemist, is the primary researcher whose breakthrough work highlights the importance of nitric oxide.
What is Nitric Oxide?
Definition: A signaling molecule in the human body essential for regulating blood flow and oxygen delivery.
Production Decline with Age: Loss of nitric oxide production is linked to age-related diseases such as erectile dysfunction, diabetes, Alzheimer's, and high blood pressure.
Importance of Nitric Oxide
Earliest Event in Disease Onset: The decline in nitric oxide is the first event in the progression of many chronic diseases.
Cardiovascular Health: Regulates vascular tone and blood pressure, which are critical for preventing cardiovascular diseases.
Symptoms and Indicators of Nitric Oxide Deficiency
Erectile Dysfunction: Often the first symptom due to reduced blood vessel dilation.
High Blood Pressure: Blood vessels cannot adequately dilate, leading to hypertension.
Exercise Intolerance and Cognitive Impairment: Reduced nitric oxide leads to decreased physical and mental performance.
Role of Nitric Oxide in Disease Prevention and Management
Alzheimer's Disease: Affects blood flow and insulin resistance in the brain. Nitric oxide can potentially correct these issues.
Rationale for Research: Dr. Bryan’s personal experience with his father’s non-healing wounds inspired his focus on nitric oxide.
Mechanisms of Nitric Oxide Production and Decline
Endothelial Function Decline: About a 10-12% reduction per decade, starting at age 30.
Role in Cellular Repair: Mobilizes stem cells and improves cellular energy production.
Challenges in Current Medical Practices
The medical industry often overlooks nitric oxide due to its business model focusing on sustained treatment rather than cures.
Criticism of Current Practices: Medicine is a business; true cures are not prioritized by the industry.
Oral Microbiome and Nitric Oxide
Mouthwash and Toothpaste: Many contain fluoride and other substances that kill beneficial bacteria responsible for nitric oxide production.
Link to Systemic Diseases: Disruption in oral microbiome can lead to or exacerbate diseases like high blood pressure.
Strategies to Improve Nitric Oxide Levels
Avoid Harmful Substances: Fluoride in toothpaste, antiseptic mouthwashes, and high-sugar diets should be avoided.
Diet and Lifestyle: A balanced diet low in sugar, moderate exercise, and avoiding antacids can help maintain nitric oxide levels.
Sunlight and Nasal Breathing: Exposure to sunlight and breathing exercises can stimulate nitric oxide production.
The Future of Medicine
Potential for Nitric Oxide: Expected to become central in global healthcare strategies due to its role in disease prevention and management.
Call to Action: Educate the public about the importance of maintaining nitric oxide levels through lifestyle changes and informed product choices.
Conclusion
The lecture emphasized the critical role of nitric oxide in maintaining health and preventing disease, highlighting the need for increased awareness and lifestyle adjustments to support its production.