Nystatin Overview

Forms of Nystatin

• Topical Form
  • Trade Name: Nystop
• Oral Form
  • Available as a pill or liquid suspension

Difference between Statins and Nystatin

• Statins
  • HMG-CoA reductase inhibitors
  • Anti-hyperlipidemic medications
  • End with the suffix "statin"
• Nystatin
  • Antifungal medication
  • Memory trick: "Nystatin is not a statin"

Mechanism of Action

• Attaches to the fungus
• Creates holes in fungal cells
• Causes infectious contents to leak out
• Results in the death of fungus

Uses of Nystatin

• Treats candida or thrush
  • Locations: Mouth, intestines, vagina, skin

Side Effects

• GI upset: Nausea, vomiting, diarrhea
• Irritation inside the mouth (liquid suspension)

Nursing Considerations

• Inspect inside of the mouth for irritation and effectiveness

Patient Education

• Take medication daily, avoid missing doses
• For denture wearers:
  • Remove and soak dentures in liquid suspension
• Shake liquid suspension well before use
  • Rinse mouth, swish medication, swallow to treat esophageal candida
• Inhaler users:
  • Rinse mouth with water after use
  • Use a spacer

Key Points

• Nystatin is available in oral and topical forms
• Inspect mouth for irritation
• Complete entire course of therapy
• Rinse mouth and use spacer with inhalers to prevent thrush

Additional Resources

• Complete Pharmacology flashcards
  • Condensed and engaging material for pharmacology students

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