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Webinar Insights on NanoEHS and Safety
Aug 22, 2024
Webinar on NanoEHS: Nanoinformatics and Modeling
Introduction
Host: Todd Luxton, Research Chemist at the EPA
Topic: What we Know about nanoEHS: Nanoinformatics and Modeling
Focus on environmental health and safety of engineered nanomaterials
Importance of the National Nanotechnology Initiative (NNI) in sharing information
Panel of Speakers
Andrea Haase
Head of Fibre- and Nanotoxicology Unit, German Institute of Risk Assessment
Expertise in integrating nanomaterials into EU regulatory frameworks.
Stacey Harper
Professor of Environmental Engineering, Oregon State University
Focus on rapid testing strategies for nanomaterials and nanoplastics.
Fred Klaessig
Manager of Pennsylvania Bio Nano Systems, co-chair of US-EU Databases for NanoEHS Community.
Robert Rallo
Director at Pacific Northwest National Laboratory
Research interests in data-driven analysis and modeling of complex systems.
Andrea Haase's Presentation: "What do we know about nanoinformatics?"
Nanosafety Overview
Nanomaterials are widely used in various applications, posing characterization and dosimetry challenges.
Complexity of nanomaterials necessitates modern data-driven approaches for hazard and risk assessment.
Need for FAIR data infrastructure (Findable, Accessible, Interoperable, Reusable) to manage data effectively.
Challenges in Data Management
Relevant information hard to find and evaluate due to fragmented datasets and poor metadata.
Importance of enriching datasets with metadata and ensuring accessibility.
NanoREG2 Project
Development of a nanosafety data interface based on eNanoMapper.
Aims to create a comprehensive nanosafety database with high FAIR scores.
Linking omics data to better assess nanosafety.
Gov4Nano Project
Establishing a FAIR data ecosystem for broader access to reliable data.
Ongoing initiatives to standardize metadata and provide analytical tools for data interpretation.
Stacey Harper's Presentation
Leveraging NanoEHS Research
Reflection on 15-20 years of nanoEHS research and its implications for new materials, particularly nanoplastics.
Discussion of challenges in data collection and the need for standardized data formats for nanomaterials.
Importance of understanding transformations of materials throughout their life cycle.
Fred Klaessig's Presentation
Role of Dissolution in Risk Assessment
Examination of how dissolution can simplify toxicological assessments.
Discussion of regulatory perspectives and differences in the evaluation of nanoparticles across regions.
Importance of understanding the physiological conditions under which dissolution occurs.
Robert Rallo's Presentation
Computational Modeling in Nanoinformatics
Advances in modeling techniques and the need for reproducibility in model results.
Importance of domain awareness for creating accurate models.
The need to integrate modeling with experimental data for better insights into nanomaterials.
Panel Discussion
Key Bottlenecks
: Data fragmentation, poor metadata, and the need for standardized approaches.
Current Successes
: Advances in computational modeling and data sharing initiatives.
Future Directions
: Emphasis on open access to datasets and the need for quality standards in data collection.
Environmental Health Considerations
: Need for well-documented measurements of dissolution and toxicity for regulatory purposes.
Conclusion
Importance of collaboration across research and regulatory bodies to improve nanosafety data accessibility.
Encouragement to continuously evolve approaches to meet the challenges of evolving nanomaterials and their implications.
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Full transcript