all right gastric acid neutralization and we're talking about antacids here this is in chapter 50. this is probably the most commonly used non-prescription drug okay that's probably important to remember right and acids are the most commonly used non-prescription drugs important to remember so mechanism of action what do they do they neutralize acid in the stomach so they do not prevent the overproduction of acid they just neutralize what acid is there okay neutralize acid in the stomach how do they do that important to remember they stimulate mucus prostaglandin and bicarbonate secretion from cells in gastric glands okay so they stimulate mucus okay stimulate mucus production so we have mucus that's a protective barrier remember it serves as a protective coating against the digestive action of hydrochloric acid and digestive enzymes we have prostaglandin that prevents histamine binding on parietal cells and we have bicarbonate and that's a buffer for hydrochloric acid okay so you want to remember all of those so stimulate mucus prostaglandin and bicarbonate secretion from cells and gastric glands it looks like stimulant is written here again that is a mistake so you're just going to ignore that therapeutic effects so what are the therapeutic effects relief of symptoms related to hyperacidity so indication so the patient with heartburn um gastritis peptic ulcer disease otherwise abbreviated as puds how you'll see that precautions may inhibit absorption of activity i'm sorry may inhibit absorption or activity of other drugs taken concurrently so that's just something to keep in mind when we're giving these particular medications i'm especially timing that administration of those so we want to be careful that if the patient's on other medications that we aren't inhibiting the action of those other medications that they're taking with an antacid contraindications would be gi obstruction possible renal failure side and adverse effects okay so important things for you to remember here all right so we have magnesium prep so if a patient were to have a magnesium prep they could have diarrhea increase mag and renal fire if the patient had renal failure what important take backs that i want you to remember most of all is two and three okay aluminum and calcium preps if the patient has an aluminum or calcium prep they could have constipation or they could actually get kidney stones from the calcium preps because you know a lot of stones are actually made up of calcium so constipation and kidney stones for calcium preps rebound hyperacidity when used long term so if a patient's using an antacid for too long and then they just stop taking it they're going to have that rebound hyper acidity problem so two and three are important for you to remember the patient could also have metabolic alkalosis and that's an over neutralization of the stomach acids nursing actions we're gonna assess therapeutic and side effects follow-up evaluation patient education on the use the need for follow-up evaluation and then your drug examples so the prototypes that you'll need to remember here are magnesium hydroxide aluminum hydroxide calcium carbonate those all should actually be hopefully more simplistic to remember we wanted to remember magnesium aluminum calcium right um those are the only three prototypes that you'll need to remember from this particular list