Amphotericin B: Key Points and Mnemonics

Introduction

• Amphotericin B: An antifungal medication.
• Usage: Reserved for severe systemic fungal infections due to many adverse effects.

Mnemonic for Amphotericin B

• Setting: Young man's apartment kitchen, cooking frog legs.
• Frog and Amphibian: Reminds of "Amphotericin".
  • Mushrooms: Represent fungal infections (antifungal properties).

Clinical Use

• Indication: Treatment for severe systemic fungal infections.
• Last Resort: Due to significant adverse effects.

Adverse Effects

1. Nephrotoxicity (Kidney Toxicity)

   • Symbol: Kidney beans falling.
   • Monitoring: BUN, creatinine, urine output.

2. Hypokalemia (Low Potassium)

   • Symbol: Empty banana peel.
   • Cause: Amphotericin B can lower potassium.
   • Management: Potassium supplementation.

3. Hypomagnesemia (Low Magnesium)

   • Symbol: Falling magnets on the fridge.
   • Cause: Amphotericin B lowers magnesium levels.
   • Management: Magnesium supplementation.

4. Infusion-related Reaction

   • Symptoms: Fever, chills, nausea, hypotension.
   • Management: Pre-medication with antipyretics (e.g., Tylenol), antiemetics.
   • Note: Reaction is expected; do not stop infusion.

Summary

• Amphotericin B: Potent antifungal for severe/systemic infections.
• Adverse Effects: Nephrotoxicity, hypokalemia, hypomagnesemia, and infusion-related reactions.
• Monitoring and Management: Close monitoring of kidney function, potassium, and magnesium levels; symptom management for infusion reactions.

Conclusion

• Recommend less risky recipes for next dates!
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This mnemonic and summary help in remembering the essential facts about Amphotericin B and preparing for test day.