Huberman Lab Podcast: Performance Medicine with Dr. Craig Conover

Introduction

• Host: Andrew Huberman, Professor of Neurobiology and Ophthalmology at Stanford School of Medicine.
• Guest: Dr. Craig Conover, Medical Doctor, expert in performance medicine.
• Focus: Use of peptides and other therapies to enhance mental health, physical health, and performance.

Peptides Overview

• Peptides: Small proteins, chains of amino acids.
  • Example: Insulin is a peptide.
  • Thousands exist in brain and body, performing various roles.
• Exogenous Peptides: Administered to activate pathways in brain and body, augmenting health.
• Peptide therapies are positioned between doing nothing and taking supplements or prescription drugs.

Discussion on Peptides

GLP-1 Agonists

• Popular Peptides: Semaglutide (Ozempic), Monjaro.
• Uses: Initially for type 2 diabetes; now for weight loss.
• Controversy around weight loss leading to muscle loss.
• Therapeutic Approach: Micro-dosing to minimize side effects.
• Benefits: Weight loss, inflammation reduction, improved cognitive function.

BPC-157

• Role: Anti-inflammatory, accelerates wound healing.
• Method of Use: Can be taken orally or injected (subcutaneously more effective).
• Current Status: Removed from FDA market; alternative is Pentadeca peptide (PDA).

Growth Hormone Secretagogues

• Peptides: Epithalon, CJC-1295, Ipamorelin.
• Function: Stimulate endogenous growth hormone release.
• Benefits: Improve sleep quality, increase growth hormone secretion.
  • Dosing: Typically taken at night, fasted for 30-45 minutes.

Other Peptides & Therapies

• Thymosin Alpha-1: Modulates immune response, effective in autoimmune diseases.
• PT-141: Used for enhancing libido, erectile dysfunction.

Discussion on Safety and Regulation

• FDA Action: Many peptides removed from the market; concern over safety and regulation.
• Market Dynamics: Pharmaceutical interests, research markets, and need for physician guidance.

Supplements and Health

• Supplement Stance: Limited use of supplements, favoring CoQ10 and methylated B vitamins.
• NAD Therapy: Transformative for energy and recovery; offered intravenously or subcutaneously.

Sleep and Cognitive Enhancement

• Pinealon: Enhances REM sleep, used with glycine for optimal results.
• Methylene Blue: Cognitive enhancer, works on mitochondrial function.

Conclusion

• Health Perspective: Emphasis on positive mindset and lifestyle changes.
• Personal Responsibility: Encourages understanding and taking control of personal health.
• Future Outlook: Continued exploration and education on the use of peptides and related therapies.

Additional Information

• Podcast Goals: Share science-based tools, zero-cost information.
• Host's Book: Upcoming book on health protocols.