Overview
This talk provides an in-depth review of S4 (Andarine), a selective androgen receptor modulator (SARM), covering its effects, legal status, usage protocols, benefits, risks, and personal experiences. The speaker emphasizes safety, legal considerations, and cautions against misuse.
Legal and Safety Concerns
- S4 is legal for purchase only as a research chemical, not for human consumption.
- It is not approved for use in performance-tested sports, including the Olympics.
- The speaker is not a medical doctor and does not recommend the use of S4.
Mechanism and Intended Effects
- S4 is a selective androgen receptor modulator (SARM) designed to stimulate muscle growth with fewer side effects than steroids.
- It provides muscle hardness, lean appearance, and increased aggression in training.
- S4 does not cause estrogenic side effects such as gynecomastia, water retention, or bloating.
Comparative Effectiveness
- S4 is considered weaker than other SARMs like RAD 140 and LGD 4033, with effects more similar to Ostarine.
- It may accelerate muscle growth theoretically five to ten times faster than natural training, but results vary by dose and individual.
Side Effects and Health Risks
- Potential for hair loss in individuals prone to male pattern baldness.
- S4 is suppressive to testosterone production, possibly leading to decreased libido and needing post-cycle therapy (PCT).
- Negative impact on cholesterol (lowers HDL, raises LDL), which may harm cardiovascular health.
- Possible liver enzyme elevations; impact varies by individual genetics.
- Can cause vision disturbances, such as yellow tint or blurred nighttime vision—these are reversible upon cessation.
- Unlikely to increase blood pressure or cause significant kidney issues for most users.
Usage Guidelines and Dosing
- For women: 10–20 mg/day, divided into multiple doses due to short half-life (4–6 hours).
- For men: 25–75 mg/day, also divided over two or more daily doses.
- Do not inject liquid S4 formulations; oral administration only.
- Gradually increase dose to monitor individual tolerance and side effects.
Positive Outcomes
- Promotes muscle gain, strength, and visible leanness without significant water retention.
- Provides a "dry," vascular, and athletic look suitable for photoshoots or maintaining appearance.
- Enhances gym aggression and training intensity.
Negative Outcomes
- Testosterone suppression frequently occurs; users often neglect necessary PCT.
- Vision side effects can be alarming but are not permanent.
- Experiences and results vary widely between individuals.
Personal Experience and Assessment
- The speaker found S4 less potent than LGD 4033 and preferred other SARMs for effectiveness.
- Felt immediate physical effects post-dosing, such as increased muscle tension and workout intensity.
- Did not experience notable vision side effects personally.
Recommendations / Advice
- Use extreme caution with SARMs; consider health risks and legal status.
- Always divide dosages throughout the day to minimize side effects.
- Start with a low dose and increase gradually to monitor side effects.
- Plan and execute proper post-cycle therapy (PCT) to mitigate testosterone suppression and related issues.