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Cell Structure and Differences

Sep 22, 2025

Overview

This lecture covered the fundamental similarities and differences between prokaryotic and eukaryotic cells, including their structures, functions, and key defining features.

Classification and Evolution

  • All living organisms are classified as either prokaryotes or eukaryotes based on cellular structure.
  • Prokaryotes were the first life forms; eukaryotes evolved from prokaryotes via endosymbiosis.
  • Endosymbiosis involved one prokaryote engulfing another, leading to organelles like mitochondria.

Shared Features of All Cells

  • Both prokaryotes and eukaryotes possess DNA, a plasma membrane, cytoplasm, and ribosomes.

Key Differences: Prokaryotes vs Eukaryotes

  • Prokaryotes lack a nucleus and membrane-bound organelles; eukaryotes have both.
  • Prokaryotes are usually unicellular and smaller (0.1–5 μm); eukaryotes are often multicellular and larger (10–100 μm).
  • Prokaryotic DNA is usually circular and found in the cytoplasm; eukaryotic DNA is linear and stored in the nucleus.
  • Prokaryotes include bacteria and archaea; eukaryotes include animals, plants, fungi, algae, and protozoans.
  • Transcription and translation are coupled in prokaryotes but separate in eukaryotes.

Prokaryotic Cell Structure and Features

  • DNA is found in a nucleoid region, not a nucleus.
  • Have ribosomes for protein synthesis, a cell wall (usually with peptidoglycan), a plasma membrane, and sometimes capsules.
  • May have pili (for attachment and DNA transfer) and flagella (for movement).
  • Do not have mitochondria, endoplasmic reticulum, or Golgi apparatus.

Eukaryotic Cell Structure and Features

  • Possess a nucleus containing chromatin (DNA and proteins).
  • Contain membrane-bound organelles such as mitochondria, endoplasmic reticulum, and in some cases, chloroplasts.
  • May have a cell wall (in plants and fungi), cytoskeleton, vesicles, and vacuoles.
  • Nucleolus inside the nucleus synthesizes ribosomal RNA.
  • Ribosomes synthesize proteins; mitochondria generate energy.

Key Terms & Definitions

  • Prokaryote — Unicellular organism lacking a nucleus and membrane-bound organelles; includes bacteria and archaea.
  • Eukaryote — Organism whose cells contain a nucleus and various membrane-bound organelles.
  • Nucleus — Membrane-bound organelle containing eukaryotic DNA.
  • Nucleoid — Region in prokaryotes where DNA is located, not membrane-bound.
  • Endosymbiosis — Process where one cell engulfs another, leading to organelles like mitochondria.

Action Items / Next Steps

  • Review cell diagrams and be able to label key structures of prokaryotic and eukaryotic cells.
  • Compare and contrast the features of prokaryotic and eukaryotic cells in preparation for quizzes or exams.