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Respiration Physiology Overview

Sep 8, 2025

Overview

This lecture covers the physiology of respiration, types of breathing, measurement methods, respiratory cycle, lung volumes, pressures, and the impact of various factors on breathing.

Physiology of Respiration

  • Respiration involves inhaling oxygen and exhaling carbon dioxide as a waste product.
  • Two types of inspiration: quiet (normal) and forced (active).
  • Two types of expiration: passive (elasticity/gravity) and active (muscle effort).
  • Active expiration compresses the abdomen and reduces thoracic size to expel air.

Measurement of Respiration

  • A spirometer measures respiration volume.
  • A manometer measures pressure within the respiratory system.

Stages of Respiration and Gas Exchange

  • Ventilation: movement of air into respiratory passageways.
  • Distribution: air spreads throughout the alveoli.
  • Perfusion: movement of fluid through a barrier in the lungs.
  • Diffusion: gas exchange across the alveolar-capillary membrane.

Respiratory Cycle and Volumes

  • One respiratory cycle = one inspiration + one expiration.
  • Adults average 12–18 cycles per minute; newborns 40–70 per minute.
  • Quiet tidal respiration is normal, restful breathing (approx. 500 mL air per cycle).
  • Alveoli increase from 25 million at birth to 300+ million by age eight.
  • Adults retain residual air; infants lack this reserve.

Lung Volumes and Capacities

  • Volumes measured in liters (L), milliliters (mL), and cubic centimeters (cc).
  • Tidal volume: amount of air inhaled or exhaled during a normal cycle.
  • Inspiratory reserve volume: extra air inhaled after a normal inspiration.
  • Expiratory reserve volume: extra air exhaled after a normal expiration.
  • Residual volume: air remaining after maximum exhalation (about 1.5 L in adults).
  • Dead space air: air in passages not involved in gas exchange (about 150 cc).
  • Capacities combine volumes; include vital capacity, functional residual capacity, total lung capacity, and inspiratory capacity.

Factors Affecting Respiration

  • Exercise, age, illness, and muscle weakness affect breathing.
  • Lung capacity remains constant but functional levels decrease with age.
  • Vital, inspiratory, and expiratory reserve capacities decrease with age; functional residual capacity increases due to loss of inspiratory capacity.

Respiratory Pressures

  • Five types: intraoral (mouth), subglottal (below vocal cords), alveolar (within alveoli), intrapleural (between pleural membranes), and atmospheric.
  • Speech requires 3–5 cm H₂O subglottal pressure; conversational speech uses 7–10 cm.
  • Pressure rapidly changes to add syllabic stress.

Posture and Speaking

  • Reclining decreases resting lung volume and increases breathing effort.
  • Normal breathing: inspiration = 40% of cycle, expiration = 60%.
  • During speech: inspiration = 10%, expiration = 90%.
  • Checking action uses muscles to control expiration for speech.

Key Terms & Definitions

  • Inspiration — Breathing in (inhalation).
  • Expiration — Breathing out (exhalation).
  • Spirometer — Device for measuring volume of air inspired or expired.
  • Manometer — Device for measuring pressure.
  • Tidal Volume — Air volume moved during a normal breath.
  • Residual Volume — Air left in lungs after maximum exhalation.
  • Vital Capacity — Max air exhaled after max inhalation.
  • Subglottal Pressure — Air pressure below vocal cords.
  • Alveoli — Air sacs for gas exchange in the lungs.
  • Dead Space Air — Air not involved in gas exchange.

Action Items / Next Steps

  • Review chapter sections on lung volumes and capacities.
  • Practice exercises for inspiratory and expiratory reserve volumes.
  • Visit the provided link on breathing types (not on quiz).
  • Be familiar with all bolded terms and their definitions.