Factor Xa Inhibitors: Key Concepts for NCLEX

Introduction

• Factor Xa inhibitors include drugs like rivaroxaban and apixaban.
• Used clinically to prevent blood clot formation.
• Mnemonic relation: Xbox game store scene, where the sign rated 10/10.
  • 10 represents Factor X being blocked (punched sign symbolizes inhibition).

Drug Names and Mechanism

• Suffix: All Factor Xa inhibitors end in -xaban.
  • Example Drugs: Rivaroxaban, Apixaban, Edoxaban.
  • Brand Names: Xarelto, Eloquis.
• Mechanism:
  • Inhibit clotting factor Xa (10a).
  • Serve as anticoagulants to prevent blood clots.

Clinical Uses

• Prevent clots in conditions like:
  • Deep Vein Thrombosis (DVT)
  • Pulmonary Embolism (PE)
  • Atrial Fibrillation (AFib)
• Note: Not effective as clot busters for existing clots.

Side Effects

• Bleeding Risk:
  • Inhibiting clotting factor increases bleeding risk.
  • More controlled bleeding risk than warfarin/heparin (no monitoring needed).
• Patient Counseling:
  • Avoid NSAIDs (increased bleeding risk).
  • Report signs of bleeding (e.g., blood in urine/stool, coughing blood, dizziness).

Key Reminders

• 10/10 Punch Symbolism:
  • Remember the connection between the Xbox and Factor Xa inhibitors.
• Clinical Cautions:
  • Steady therapeutic level reduces bleeding risk.
  • Monitor for any unusual bleeding symptoms.

Conclusion

• Factor Xa inhibitors are crucial anticoagulants with a specific suffix to recognize.
• Used for preventive care in clotting disorders.
• Be mindful of their bleeding risk and counsel patients accordingly.

Remember, the mnemonic with the Xbox store is a helpful way to recall the association between the drug mechanism and its clinical application. Continue reviewing these concepts to solidify your understanding for the NCLEX.

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