Transcript for:
Understanding Cell Structure and Microscopy

Title: Cell Structure URL Source: blob://pdf/889e7749-c2f4-470c-9ea1-f8f73ce04a0d Markdown Content: Cell Structure AS Level Chapter 1 Chapter Outline Part 1: Microscopy Magnification vs Resolution Light Microscope vs Electron Microscope Part 2: Micrometry: How do we measure cells? Calibrating EPG using the Stage Micrometer (Practical 1) Magnification Part 3: Cell Structure and Function Organelles Animal vs Plant cells Eukaryotes vs Prokaryotes Viruses Updated on 12/7/21 by Beh SJ @behlogy MICROSCOPY LIGHT MICROSCOPES AND ELECTRON MICROSCOPES Updated on 12/7/21 by Beh SJ @behlogy Types of Microscopes Electromagnetic radiation (light / electrons) Image of specimen 1. Light microscope 2. Electron microscope a) Transmission Electron Microscopes (TEM) b) Scanning Electron Microscopes (SEM) > Updated on 12/7/21 by Beh SJ @behlogy ## Magnification and Resolution 1) Magnification Number of times an image is enlarged, compared with the actual size of the object x sign placed in front of number 2) Resolution Ability to distinguish between two points clearly as separate Units in nm Increase in magnification increase in resolution > Updated on 12/7/21 by Beh SJ @behlogy ## Magnification Updated on 12/7/21 by Beh SJ @behlogy Resolution High resolving power Low resolving power Updated on 12/7/21 by Beh SJ @behlogy What determines resolution? Range of electromagnetic radiations of different wavelengths Electromagnetic spectrum Shorter wavelength used Higher resolving power Wavelength of visible light is longer than of an electron Ability to distinguish between two points is lower Max resolution is the Shortest distance between 2 separate points The max resolution = wavelength used Shorter wavelength = higher max resolution = lower resolution > Updated on 12/7/21 by Beh SJ @behlogy ## Resolution For example: Max resolution is the Shortest distance between 2 separate points The max resolution = wavelength used Wavelength of visible light = 400 -700nm Max resolution of a light microscope = 200nm If closer/smaller than 200nm , points cannot be distinguished as separate Can a ribosome (smallest organelle) of 25nm be seen? > Updated on 12/7/21 by Beh SJ @behlogy ## Light Microscope Source of electromagnetic radiation: Visible light - Wavelength = approx. 400 -700nm - Lower energy and longer wavelength than electrons - Focused using mirrors and glass lenses Highest magnification: x1,500 Max resolution : 200nm (low) Advantage: Live specimens can be viewed, image can be coloured Used for viewing structures that can be measured in m Updated on 12/7/21 by Beh SJ @behlogy Electron Microscope Source of electromagnetic radiation: Free electrons - Wavelength = approx. 1 nm - High energy, very short wavelength - Must be in a vacuum environment so electron can travel in straight lines - Use electromagnetic lenses Highest magnification: x250,000 Max resolution: 0.5 nm (high) Disadvantage: Only dead material can be examined in vacuum, images are black and white Used for viewing structures that can be measured in nm Updated on 12/7/21 by Beh SJ @behlogy Updated on 12/7/21 by Beh SJ @behlogy Types of Electron Microscopes a) Transmission Electron Microscopes (TEM) b) Scanning Electron Microscopes (SEM) > Updated on 12/7/21 by Beh SJ @behlogy ## Transmission Electron Microscopes Beam of electrons Pass through (transmit) specimen before being viewed 2D appearance Details inside cells Internal structures Membranes within internal structures > Updated on 12/7/21 by Beh SJ @behlogy ## Scanning Electron Microscopes Lower resolution compared to TEM Scan surfaces of specimens 3D appearance > Updated on 12/7/21 by Beh SJ @behlogy Q: List the differences between a light microscope and an electron microscope. [4] This is how you should ALWAYS present your answer to compare/contrast between 2 things. Features Light Microscope Electron Microscope E.g. Highest magnification of microscope Low er High er 4 marks = 4 points (1 mark is for table plus 1 just in case) DO NOT tick or cross in the box. Use comparative language. Make your Feature as specific as possible. (e.g. instead of magnification, write highest magnification of microscope) > Updated on 12/7/21 by Beh SJ @behlogy Features Light Microscope Electron Microscope Type of radiation Light Electrons Radiation travels through Air Vacuum Wavelength of radiation Longer 400 -700 nm Shorter 1 nm Highest magnification of microscope Lower x1500 Higher x250,000 Max. resolution of microscope Lower 200 nm Higher 0.5 nm State of specimen Live Dead Q: List the differences between a light microscope and an electron microscope. [4] A: > Updated on 12/7/21 by Beh SJ @behlogy # MICROMETRY HOW DO WE MEASURE CELLS? Updated on 12/7/21 by Beh SJ @behlogy Units SI unit for length metre (m) Suitable units for Light microscope = micrometre (m) Electron microscope = nanometre (nm) Note: Always measure image length in mm !!! Present the actual diameter of structure in m > Updated on 12/7/21 by Beh SJ @behlogy Eyepiece graticule (EPG) is on the eyepiece lens Stage micrometer is placed on the stage ## How do we measure cells? > Updated on 12/7/21 by Beh SJ @behlogy ## How do we measure cells? Two components needed: The stage micrometer Shows the true value of length (Usually 10mm in length with 100 small divisions) Appears bigger when magnification increases The eyepiece graticule (EPG) Shows 100 graticule units (100 EPG) which are in arbitrary units Appears constant no matter the magnification > Updated on 12/7/21 by Beh SJ @behlogy (appears larger) (appears constant) Updated on 12/7/21 by Beh SJ @behlogy Two Steps: 1. Calibrate the EPG with the stage micrometer 1 EPG = __?___div = __?__ m 2. Use the EPG to measure cell/structure 1 cell = ___?__ EPG =__?__ m ## How do we measure cells? > Updated on 12/7/21 by Beh SJ @behlogy 1. Calibrate the EPG with the stage micrometer 1 EPG = __?___div = __?__ m 15 EPG = 10 div = 0.1 mm 1 EPG = 0.1 mm/15 = 100 m/15 = 6.67 m Eyepiece Graticule Stage Micrometer mm > Updated on 12/7/21 by Beh SJ @behlogy 2. Use the EPG to measure cell/structure 1 cell = ___?__ EPG =__?__ m Diameter of cell = 11 EPG 1 EPG = 6.67 m Diameter of cell = 11 EPG * 6.67 m = 73.37 m Updated on 12/7/21 by Beh SJ @behlogy Now you try! Hint 1: the stage micrometer could be magnified under the microscope Hint 2: 10 EPG is marked 1 here! 1. Calibrate the EPG with the stage micrometer 1 EPG = __?___div = __?__ m Q: Given that 100 divisions of the stage micrometer measures 1mm, calibrate the EPG. > Updated on 12/7/21 by Beh SJ @behlogy A: 100div = 1mm 1div = 0.01mm = 10m 50 EPG = 10div 50 EPG = 10 * 10m = 100 m 1 EPG = 100 m / 50 = 2m Q: Given that 100 divisions of the stage micrometer measures 1mm, calibrate the EPG. > Updated on 12/7/21 by Beh SJ @behlogy Number of times an image is enlarged , compared with the actual size of the object Formula: = Remember to convert all measurements to the same units! Pro tip: ## Magnification 1. Convert 2. Substitute 3. Calculate > Updated on 12/7/21 by Beh SJ @behlogy ## Exercise Q: On an electromicrograph , a mitochondrion measures 36mm in length. If the magnification of the micrograph is x30,000, what are the actual length of this organelle in m? M = x30,000 I = 36mm = 36*1000 m = 36000 m A = I / M = 36000 m / 30 000 = 1.20 m 1. Convert 2. Substitute 3. Calculate > Updated on 12/7/21 by Beh SJ @behlogy Q: Given that the magnification of this electron micrograph is x20,000, calculate the actual length of this mitochondria. ## Exercise 60mm > Updated on 12/7/21 by Beh SJ @behlogy Q: Given that the magnification of this electron micrograph is x200,000, calculate the actual length of this mitochondria. M = x20,000 I = 60mm = 60 * 1000 m = 60,000 m A = I / M = 60,000 m / 20000 = 3 m ## Exercise 1. Convert 2. Substitute 3. Calculate > Updated on 12/7/21 by Beh SJ @behlogy Q: This is a micrograph taken by an electron microscope of the egg of an Aedes mosquito. What is the magnification of this image? ## Exercise You need to physically measure the scale bar! A = 200nm I (measured) = 13mm = (13*1000*1000)nm = 13000000nm M = I / A = 13000000 / 200 = x65,000 Magnification should always have a x in front and expressed in whole numbers > Updated on 12/7/21 by Beh SJ @behlogy # CELL STRUCTURE # AND FUNCTION Updated on 12/7/21 by Beh SJ @behlogy Cell Structure and Function Organelles Functionally and structurally distinct part of a cell Surrounded by membranes For compartmentalization So that reactions do not interfere with each other Each has separate, specific function Ultrastructure of cells Not necessarily surrounded by membranes Detailed structures of a cell Only can be seen under an electron microscope > Updated on 12/7/21 by Beh SJ @behlogy Two types of cells: Prokaryotes vs Eukaryotes on the Tree of Life Lets talk about this type of cells first! > Updated on 12/7/21 by Beh SJ @behlogy ## List of Eukaryotic Cell Structures Plant + Animal Cells included! 1. Cell surface membrane 2. Nucleus, nuclear envelope and nucleolus 3. Ribosomes 4. RER 5. SER 6. Golgi body 7. Lysosomes 8. Mitochondria 9. Chloroplast 10. Cell wall 11. Plasmodesmata 12. Vacuole and tonoplast 13. Centrioles 14. Microtubules 15. Cilia 16. Microvilli 1) Name it 2) Recognise it 3) Know its function You need to: > Updated on 12/7/21 by Beh SJ @behlogy Electromicrograph of a cell You should learn to identify the main organelles visible here! > Updated on 12/7/21 by Beh SJ @behlogy ## 1. Cell Surface Membrane Plasma membrane ~7 nm thick Seen as three layers at x100,000 Trilaminar appearance Partially permeable Made of phospholipid bilayer Function : Controls movement of substances into and out of the cell > Updated on 12/7/21 by Beh SJ @behlogy Largest organelle! Has double membranes General Function : Contains genetic information for the synthesis of proteins Site of transcription of genes and production of mRNA DNA is protected from degradation by enzymes ## 2. Nucleus > Updated on 12/7/21 by Beh SJ @behlogy Components: 1. Nuclear envelope Attached to ER 2 membranes Have nuclear pores Function : Controls movement of substances between nucleus and cytoplasm 2. Nucleolus Densest region Function : Site of ribosomal RNA (rRNA) synthesis Site of ribosome assembly 3. Chromatin = DNA and its associated proteins ## 2. Nucleus > Updated on 12/7/21 by Beh SJ @behlogy ## 3. Ribosomes Smallest organelle! Not bound by a membrane Made of rRNA , that is synthesized in nucleolus + some protein Has 2 subunits Function : Site of protein synthesis > Updated on 12/7/21 by Beh SJ @behlogy ## 3. Ribosomes Two types: 1. 80S ribosomes are 25nm (rmb this!) Larger Found in cytoplasm and RER of all eukaryotes 2. 70S ribosomes are 18nm Smaller Found in mitochondria and chloroplasts of eukaryotes Found in all prokaryotes Updated on 12/7/21 by Beh SJ @behlogy 4. Rough Endoplasmic Reticulum Extensive, connected system of membranes Made of cisternae (flattened membrane sacs) Continuous with the nuclear envelope Running through the cytoplasm 80S ribosomes are attached Functions : Site of protein synthesis , protein modification e.g. protein folding e.g. glycosylation = addition of carbohydrate chains to protein protein transport to Golgi > Updated on 12/7/21 by Beh SJ @behlogy ## 5. Smooth Endoplasmic Reticulum ER without ribosomes Function: Site of lipid and steroid synthesis e.g. cholesterol, steroid hormones > Updated on 12/7/21 by Beh SJ @behlogy ## 6. Golgi body Golgi apparatus / complex Made of cisternae Have layered appearance No connection between members Not continuous with nuclear envelope Swellings at end of sacs for vesicle formation Constantly being formed and broken down Being formed by : Transport vesicles from RER on cis face Broken down to form : Secretory vesicles and lysosomes on trans face > Updated on 12/7/21 by Beh SJ @behlogy Functions : Modification of proteins and lipid E.g. glycosylation phosphorylation = addition of phosphate gp to proteins cutting / folding proteins Packaging molecules into vesicles for transport Formation of secretory vesicles for release of protein out of the cell Formation of lysosomes ## 6. Golgi body > Updated on 12/7/21 by Beh SJ @behlogy ## Production and Secretion of Proteins Updated on 12/7/21 by Beh SJ @behlogy Production and Secretion of Proteins Updated on 12/7/21 by Beh SJ @behlogy Production and Secretion of Proteins List the cell structures involved in sequence: Steps: 1. Synthesis of protein at ribosome / RER 2. Transport vesicle buds off RER and fuses with Golgi body 3. Modification of protein at Golgi body 4. Separation of a secretory vesicle from the Golgi body 5. Fusion of the vesicle with the cell surface membrane 6. Contents released / secretion of protein by exocytosis Process also works to embed a protein at the cell membrane. OUT > Updated on 12/7/21 by Beh SJ @behlogy ## Exercise [CIE, June 2013, P13, Q5] When mucus is secreted from a goblet cell in the trachea, these events take place. 1. addition of carbohydrate to protein 2. fusion of the vesicle with the plasma membrane 3. secretion of a glycoprotein 4. separation of a vesicle from the Golgi apparatus What is the sequence in which these events take place? A: 1 4 2 3 > Updated on 12/7/21 by Beh SJ @behlogy Very, very small Spherical, small sacs Function: Contains hydrolytic enzymes / lysozymes Breakdown unwanted structures via hydrolysis in an acidic enviro Worn out organelles or dead cells In WBC, lysozymes digest bacteria ## 7. Lysosomes > Updated on 12/7/21 by Beh SJ @behlogy ## 8. Mitochondria Relatively large organelle Has double membranes Cristae = folded inner membrane Matrix = interior solution Contain 70S ribosomes and small circular DNA Divide by binary fission Have prokaryotic origin > Updated on 12/7/21 by Beh SJ @behlogy ## 8. Mitochondria Functions : Site of aerobic respiration synthesize ATP/produce energy in the form of ATP release energy Please DO NOT write Mitochondria produces energy Mitochondria is the powerhouse of the cell -.- > Updated on 12/7/21 by Beh SJ @behlogy Label the following electron micrograph of an animal cell. ## 8. Mitochondria > Updated on 12/7/21 by Beh SJ @behlogy ## 8. Mitochondria Q: Why are these mitochondria shaped so differently? A: One is a longitudinal cross section and the other is a transverse cross section! Also shape may sometimes vary. > Updated on 12/7/21 by Beh SJ @behlogy ## 9. Chloroplasts Relatively large organelle Oval shaped Two membranes Contain chlorophyll Thylakoid = flattened membrane sacs Grana = thylakoid stacks Stroma = interior solution Contains 70S ribosomes, small circular DNA and starch grains Divide by binary fission Have prokaryotic origin > Updated on 12/7/21 by Beh SJ @behlogy ## 9. Chloroplasts Updated on 12/7/21 by Beh SJ @behlogy 9. Chloroplasts Updated on 12/7/21 by Beh SJ @behlogy 9. Chloroplast Function: Site of photosynthesis Two main processes in photosynthesis: 1. Light -dependent reaction (aka light reaction) Light energy absorbed and water is used to synthesise ATP 2. Light -independent reaction (aka dark reaction) ATP used to convert CO 2 into glucose > Updated on 12/7/21 by Beh SJ @behlogy ## 10. Cell Wall Thick, rigid layer Made of cellulose Permeable Bcs there are spaces / gaps between fibres Functions : Provide structural support Prevent bursting Limit cell size > Updated on 12/7/21 by Beh SJ @behlogy ## 11. Plasmodesmata Strands of cytoplasm passing through channels Functions : Allows substances to pass From cell to cell Without passing through cell walls E.g. water, sucrose, amino acids, minerals ions, ATP Allows more rapid transport of substances > Updated on 12/7/21 by Beh SJ @behlogy ## 12. Vacuoles and ## Tonoplast Commonly found in plant cells Large, permanent, central Surrounded by a partially permeable membrane called tonoplast Functions : Store of cell sap (contains water, ions, minerals, salts, pigments, sugars) Stores waste products Pushes chloroplasts to edge of cell Gives turgidity to the cell > Updated on 12/7/21 by Beh SJ @behlogy ## 12. Vacuoles and ## Tonoplast Updated on 12/7/21 by Beh SJ @behlogy 13. Centrioles and Centrosomes Centrioles are cylindrical Made of 9 groups of 3 microtubules Not found in plant cells Functions of Centrioles : Involved in cell division Replicates before each cell division and moves to opposite poles Centrioles are found in pairs at right angles (90 o) from each other Forms centrosome Modified centrioles are also found elsewhere e.g. in flagella / cilia Acts as a Microtubule Organising Centre (MTOC) Organises / assembles microtubules > Updated on 12/7/21 by Beh SJ @behlogy ## 13. Centrioles and Centrosomes Function of Centrosomes : It is a MTOC Organises / assembles microtubules For the formation of spindle fibres At opposite poles During cell division /mitosis Aid contraction of spindle fibres to separate sister chromatids > Updated on 12/7/21 by Beh SJ @behlogy ## 14. Microtubules Very small (~25nm) Made from tubulin Form dimers Dimers polymerise to form long protofilaments 13 protofilaments = 1 microtubule Long, rigid, hollow tubes Formed and broken down at Microtubule Organising Centres (MTOCs) E.g. centrosomes, centrioles near flagella/cilia Updated on 12/7/21 by Beh SJ @behlogy 14. Microtubules Updated on 12/7/21 by Beh SJ @behlogy 14. Microtubules Functions : Make up the cytoskeleton (together with actin filaments) Provides mechanical support Acts as an intracellular transport system for movement of vesicles or other components > https://www.youtube.com/watch?v=y -uuk4Pr2i8 Beating of flagella Makes up spindle fibres and centrioles used in cell division > Updated on 12/7/21 by Beh SJ @behlogy ## 15. Cilia Only found in eukaryotes Smaller in diameter than microvilli Also not to be confused with flagella (mostly found in prokaryotes) Motile / moves rhythmically Complicated structure made of microtubules Function : For movement / locomotion E.g. ciliated epithelial cells in lungs, Paramecium (eukaryotic microbe) > Updated on 12/7/21 by Beh SJ @behlogy ## 16. Microvilli Only found in animal cells Found on epithelial cells in the intestines and kidneys Finger -like extensions of the cell surface membrane Functions : Increase surface area of the cell membrane for: Absorption Secretion of enzymes Digestion at the cell surface Excretion of waste substances > Updated on 12/7/21 by Beh SJ @behlogy ## Centrifugation Q: What happens if we rupture cells and spin them at high speed? A: The larger structures will sediment first. > Updated on 12/7/21 by Beh SJ @behlogy Compare and contrast the structure of an animal cell and a plant cell. [4] Feature Animal cell Plant cell Similarities: Differences: > Updated on 12/7/21 by Beh SJ @behlogy ## Similarities between ## Animal and Plant Cells Plasma membrane Nucleus Nucleolus Cytoplasm Other organelles (eg : mitochondria, Golgi apparatus, ribosomes, lysosomes) > Updated on 12/7/21 by Beh SJ @behlogy Differences between Animal and Plant Cells Feature Animal Cells Plant Cells Shape of cell No fixed shape Fixed shape Presence of Cell Walls Absent Present Presence of plasmodesmata Absent Present Presence of vacuoles Absent, if present, small, temporary Present, large and permanent Presence of chloroplasts Absent Present Presence of centrosomes Present Absent > Updated on 12/7/21 by Beh SJ @behlogy Two types of cells: Prokaryotes vs Eukaryotes on the Tree of Life Now lets talk about this type of cells! > Updated on 12/7/21 by Beh SJ @behlogy ## Prokaryotes vs Eukaryotes Pro karyotes pro = before karyon = nucleus Includes all bacteria and archaea Eu karyotes eu = true karyon = nucleus Includes plants, animals, fungi and other microbes > Updated on 12/7/21 by Beh SJ @behlogy ## Prokaryotic Cells: A typical bacterium Unicellular Relatively smaller ( 1-5m ) Simpler in structure Divides by binary fission What all bacteria do not have: No membrane -bound organelles No nucleus DNA lies free in cytoplasm in the nucleoid region > Updated on 12/7/21 by Beh SJ @behlogy ## Prokaryotic Cells: A typical bacterium What all bacteria have: Plasma membrane Cytoplasm Peptidoglycan cell wall m ade of chains crossed linked by amino acids 70S ribosomes Circular DNA DNA is naked not associated with proteins > Updated on 12/7/21 by Beh SJ @behlogy What is only present in some bacteria: 1) Plasmids Small, circular DNA Codes for non -essential proteins Several may be present 2) Pili Sexual reproduction For attachment to other cells/surfaces ## Prokaryotic Cells: A typical bacterium > Updated on 12/7/21 by Beh SJ @behlogy ## Prokaryotic Cells: A typical bacterium 3) Flagellum Locomotion 4) Capsule Outer coat, additional protection Attach to surfaces 5) Infoldings of plasma membrane (mesosomes) For photosynthesis / nitrogen fixation > Updated on 12/7/21 by Beh SJ @behlogy ## Prokaryotes, ## Mitochondria and Chloroplast They have a lot in common! Both have: Similar size Small, circular DNA 70S ribosomes Division by binary fission But why??? > Updated on 12/7/21 by Beh SJ @behlogy A: The Endosymbiotic Theory https://www.youtube.com/watch?v=FGnS -Xk0ZqU P/S: This is not in syllabus! ## Prokaryotes, ## Mitochondria and Chloroplast Updated on 12/7/21 by Beh SJ @behlogy Compare and contrast the structure of a eukaryotic cell and prokaryotic cell. [4] Feature Prokaryotic cell Eukaryotic cell Similarities: Differences: > Updated on 12/7/21 by Beh SJ @behlogy ## Eukaryotic Cells Larger (~10 -100m in diameter) Has membrane -bound organelles Has nucleus DNA is linear DNA associated with proteins Larger 80S ribosomes Cellulose cell walls (plants) Chitin cell walls (fungi) > Updated on 12/7/21 by Beh SJ @behlogy ## Viruses Non -cellular structure ~50 times smaller than bacteria (20 -300nm) Much simpler No plasma membrane, cytoplasm, ribosomes Only: 1. Nucleic acid core = DNA or RNA 2. Capsid = protein coat - Protective coat - May have one or two coats 3. Some viruses also have an outer envelope made of phospholipids 4. Some proteins may be present - e.g. haemagglutinin, neuraminidase > Updated on 12/7/21 by Beh SJ @behlogy ## Viruses All parasitic Can only reproduce by infecting living cells Uses protein synthesising machinery of host cell to replicate Are they considered living? > Updated on 12/7/21 by Beh SJ @behlogy ## List of Eukaryotic Cell Structures Plant + Animal Cells included! 1. Cell surface membrane 2. Nucleus, nuclear envelope and nucleolus 3. Ribosomes 4. RER 5. SER 6. Golgi body 7. Lysosomes 8. Mitochondria 9. Chloroplast 10. Cell wall 11. Plasmodesmata 12. Vacuole and tonoplast 13. Centrioles 14. Microtubules 15. Cilia 16. Microvilli 1) Name it 2) Recognise it 3) Know its function You need to: > Updated on 12/7/21 by Beh SJ @behlogy ## Important Terms to Remember Pay attention to those bold, highlighted red text and whats emphasised in class! In addition to the list of 16 eukaryotic cell structures to remember: Bacteria (Prokaryote) (No membrane -bound organelles) 1. Nucleoid region 2. Peptidoglycan cell wall 3. Circular DNA 4. 70S ribosome 5. Plasmids Virus 1. DNA / RNA 2. Capsid (protein coat) 3. Envelope > Updated on 12/7/21 by Beh SJ @behlogy ## Chapter Outline Part 1: Microscopy Magnification vs Resolution Light Microscope vs Electron Microscope Part 2: Micrometry: How do we measure cells? Calibrating EPG using the Stage Micrometer (Practical 1) Magnification Part 3: Cell Structure and Function Organelles Animal vs Plant cells Eukaryotes vs Prokaryotes Viruses Updated on 12/7/21 by Beh SJ @behlogy Videos Seeing the Invisible: van Leeuwenhoek's first glimpses of the microbial world: https://www.youtube.com/watch?v=ePnbkNVdPio Principles of electron microscopes https://www.youtube.com/watch?v=ljTEG -B-kGc Organelles involved in protein synthesis https://www.youtube.com/watch?v=26y1PCkWiIc Inner Life of the Cell (3:00 onwards its hard to understand what he is saying, but the 3D animations gives you a clue on how the cytoskeleton works and how protein production relies on it too!) https://www.youtube.com/watch?v=FzcTgrxMzZk Inside the living cell https://www.youtube.com/watch?v=d4TJ4NY1IA0 OK warning! All videos are for reference and entertainment only and ALWAYS contain too much/ too little/irrelevant info.