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Metoclopramide: Uses, Dosage, and Precautions

Apr 23, 2025

Metoclopramide Oral: Overview and Usage

Purpose and Indications

  • Used to treat certain stomach and intestinal conditions.
  • Short-term treatment (4-12 weeks) for ongoing heartburn when other medications are ineffective.
  • Primarily for heartburn after meals or during the day.
  • Reduces esophagus damage and aids in healing.
  • Treats diabetic gastroparesis to decrease nausea, vomiting, and stomach fullness.
  • Works by blocking dopamine, speeding up stomach emptying, and intestinal movement.
  • Not recommended for children due to serious side effects.

Administration Guidelines

  • Read the Medication Guide with every refill.
  • Consult doctor or pharmacist with questions.
  • Taken orally, usually 4 times daily (30 minutes before meals and at bedtime).
  • Use a special measuring device for liquid forms.
  • Dosage based on medical condition, treatment response, age, and other medications.
  • Do not exceed recommended usage due to tardive dyskinesia risk.

Special Considerations

  • For episodic heartburn, take single doses before triggers.
  • In diabetic gastroparesis, typically used for 2-8 weeks.
  • Regular usage is advised; taper dose to avoid withdrawal.

Side Effects

  • Common: drowsiness, dizziness, tiredness, trouble sleeping, agitation, headache, diarrhea.
  • Serious side effects: mental/mood changes, muscle spasms, Parkinson-like symptoms, abnormal breast changes.
  • Rare conditions: neuroleptic malignant syndrome (NMS), tardive dyskinesia.

Warnings and Precautions

  • Monitor blood pressure due to increase risk.
  • Potential for serious allergic reactions.
  • Health considerations include history of movement disorders, intestinal blockages, breast cancer, high blood pressure, liver issues, etc.
  • May cause dizziness/drowsiness; avoid alcohol and marijuana.
  • Liquid products may contain alcohol.
  • Discuss all medications with healthcare provider to avoid interactions.
  • Pregnancy: use only when clearly needed; consult on breastfeeding.

Drug Interactions

  • Antipsychotics, dopamine agonists, MAO inhibitors, and others may interact.
  • Can affect absorption of other medications due to increased gastric emptying.

Handling and Storage

  • Store at room temperature, away from light and moisture.
  • Keep out of reach of children and pets.
  • Do not flush or pour down drain.

Additional Resources

  • Consult healthcare provider for missed doses, storage details, and lab tests.
  • Detailed images and descriptions of various forms and dosages provided.

Notes

  • This document supplements but does not replace professional medical advice.
  • Consult healthcare professionals before making any changes to medication or treatment plans.