what if I told you experts now predict the
current generation of us children will be the first in history to live shorter lives
than their parents when I first heard this I was completely stunned how could this be and
if true is there a way to reverse this trend I'm Jason Paul and I want to welcome you to the human
longevity project what started out as a 60 minute documentary has now expanded into a nine part
series that will reveal the surprising sources of our dramatic health decline in the last 80 years
alone we'll take you on a journey around the globe to uncover lost wisdom from some of the world's
healthiest and longest living people you'll get a rare glimpse into the lives of centenarians
remote parts of the world and experience what their environment and lifestyle was really like
growing up in addition we have interviewed over 90 health experts to explain how we've gotten so
far off track and what we can do to put an end to this chronic disease epidemic we now face will
cover a lot of ground in the series and you're going to learn exactly what aging is how to slow
this process and ways you can apply this knowledge today to live a longer happier and more fulfilled
life I hope you're ready for a new perspective on longevity I think you'll find the information in
this series collapses the old paradigm of disease management and provides a refreshing new look on
health creation we welcome you to our community and ask for your continued support to spread
this message of health by registering to watch this series you're joining hundreds of thousands
of people who have already said yes to a brighter future because of you someone you know may get the
solutions they desperately need from this series so fleets at the share button below and with your
help we can set a new trajectory for health and longevity in the modern world I know we can do
better we have to if you have any questions or comments about this series please leave them
below from all of us at the human longevity project we thank you for joining us on this
very important mission enjoy episode 1 [Music] so it you know we don't need to go and do ancient
history to think about the the changes that really matter for us so if we just go back to the early
1900s this was the beginning of the electric light bulb and prior to that we didn't really see shift
work and then we move forward a little bit more and we see the development of antibiotics which
changed the world and has saved millions of lives billions of lives potentially then we had the
industrialization of our food supply where is you you know not that long ago the bulk of the
food that we ate was raised fairly locally it was consumed rather locally we had a seasonal
variation to it we didn't always have oranges and watermelons around and and stuff like that you
know in the the dead of winter if we go back just a little bit you know when I was born this was
pre Information Age so people watch TV there were three channels when you when you got up and turned
onto the TV and then with the development of the Information Age we've seen a dramatic decrease in
the amount of physical activity that people do and then now in the the modern Information Age we can
work from home order our food to our front door never go outside go online and tell our doctor
that we have a sore throat and get nmi addicts delivered to the front door we never can we could
construct a life where we literally never have any meaningful social interaction we try to paper
over that with social media and so in a very brief period of time really in the period of one very
long lifetime or certainly two generations longer lifetimes we've seen every facet of our lives
change and change in really profound ways and in a larger way than happened in the totality the
rest of history the epidemic of chronic illness has not yet spread to developing nations it is
really a problem in modern industrialized world so the question is why are awesome ADHD asthma
other immune diseases allergies why are these so endemic in modern industrialized world why is it
that we see so many kids in the United States in the UK and Australia with these skyrocketing rates
of every chronic illness out there and the reason why is because we live differently when you're
looking for the connection between the wives why do we have such an explosion of chronic disease
where is it coming from and you see it's in the last 30 40 50 years then you look to see what's
happened in the last 40 50 60 years is there anything that's changed that may contribute
to the end point result where we're getting sicker quicker now it's official the experts
in epidemiology have confirmed that in the last few years life expectancy is not growing anymore
it's regressive and inside us say it's actually regressive since 1997 but the official numbers
is known the last two years it's going downhill it's going downhill rapidly meaning that many
people my age will actually see and maybe your age also is significantly younger but many of you
will outlive your own children we have the crisis coming that needs to be acknowledged we have
more scientists more doctors more therapists more gyms more chiropractors more osteopaths and
more nutritionists per capita than we've ever had and we're the sickest people we've ever been if
you look in the index of medical textbook that a medical student would see in their program
and you look for health in the index of that textbook you're not gonna find anything there's no
definition of health in most medical textbooks the primary focus is on disease up until really very
recently people had every reason in the world to think that health and disease were a matter either
of bad luck punishment from God or more recently the unfortunate scripting in our genetics of just
a bad health hand and so the the predetermination was made that I'm gonna live a life of chronic
disease my parents had diabetes Alzheimer's runs in my family whatever you hear this all the time
and and this this is you know just echoes of a tired old outdated story of health we have a
healthcare system that evolved in the context of acute problems and was really set up to deal
with those and it does a fantastic job by the way of dealing with those acute problems if I get
hit by a bus I I definitely want to go to the hospital but it fails miserably when it comes
to these complex chronic problems and that is the next barrier that we have to overcome in
the search for longevity is looking how do we understand how to keep ourselves healthy over
the long term and that's not something that the medical system has ever really thought about that
wasn't really in their remit and the truth is is that it's probably not going to be created by a
medical system it's going to be created mainly by patients and patients being inspired by content
by providers by each other the more you learn the more you realize that we've we've allowed
ourselves to become incredibly dependent on the healthcare system in general on pharmaceuticals
in general and and have allowed the the industry to take enormous advantage of the population the
payer system the taxpayer and it's gotten way out of control so we are currently in a situation
characterized by the fact that almost 10% of the pediatric population in America is being
treated with psychotropic medications we have reports through the NHS of in Scotland actually
of a one-year-old baby you know being medicated psychiatrically this is a possible outcome
of a refusal to acknowledge that something is wrong you know we treat the body as if it's a
bunch of different parts and we go to the doctor for that part we have a headache we go to the
head doctor the problem is our headache might be caused by what we're eating or by our gut flora
or by a nutritional deficiency or by a toxin and we don't have a way of mapping that because the
the way that the science is shifting so fast we haven't caught up clinically it's estimated that
over sixteen million Americans currently suffer from an autoimmune condition and more than 70% of
adults across the u.s. have already been diagnosed with a chronic disease and perhaps what's most
shocking is that by the year 2030 it's estimated that nearly half of Americans will be diagnosed
with cancer at some point in their life things are getting worse and the medical system doesn't
appear to be equipped to handle chronic disease so before we can address the question of longevity
let's explore the aging process and try to get a better understanding of what aging actually is
it depends on how you live your life for some people aging will be the passage of time for some
people aging will be the accumulation of wisdom and experience and and so it really depends on
what side of the fence you're on but you know we can define it biochemically by looking at lab
markers and looking at you know novel blood work or we can look at it as a human experience and the
human experience is really all about experience and so aging isn't essentially an accumulation of
those experiences and it's really an accumulation of wisdom as well aging is the process of where
we let go of flow flow in the body so things start to stiffen become stagnant become more rigid how
I define aging is it's a lack of playfulness you know evaporating out of the body as well as
the psychology so for me what keeps us young the Fountain of Youth is playfulness aging is a
process where you just get older you shrivel up and die it's a loss of the ability of our cells to
adapt to their environment quickly and efficiently the health of your cells pretty much determines
the health of you like from the cells of your brain to the cells of your digestive system it all
boils down to cellular health you know from from a human health perspective when you're looking at
aging you're looking at the ways that the human body is able to sustain itself despite the fact
that cells are dying at a more rapid rate how can we continue to adapt even though we're getting
older and moving closer towards death with ample aging what we have is we have state in which you
have you go into more of a catabolic than anabolic state so a city with tissues regenerating and
renewing at a healthy weight and your mitochondria being efficient those systems don't become
impaired then then your mitochondria comes less efficient you can't produce much energy don't have
as much cell division you become more horrible the disease you're more prone to inflammation you
can't watch that your feedback loops then that leads to every disease becoming a greater risk
to develop as these processes take place over the years there's been lots of different theories
about what kind of layer of physiology is the true source of illness of symptoms of disease of aging
itself well in in recent years there's been some really breakthrough research that is now zeroing
in on the mitochondria as the most upstream system my perspective of Aging it comes from more
mitochondrial perspective if we speak about mitochondrial aging then we are looking at the
increased number of mitochondria that's getting damaged as you get older and when you when that
happens a lot more cells also die in the process because mitochondria regulate that apoptosis or
cell death now there is a balance or trash hole point which is happens they say it's around mid
40s where everything tilts to the aging process but in terms of mitochondrial aging is essentially
the accumulation of all the mitochondrial mutations from oxidative stress and then that
translates to senescence and cell death [Music] now this is reflected in the organs that go first
in aging that are affected by chronic diseases for example the brain the heart the kidneys the
endocrine organs or those that produce hormones and your muscles they go first because these
organs have very high mitochondria numbers of mitochondria in them and they have a very high
energy demand but they have a very low energy reserve so when the mitochondria start to go
this particular organs start to go all right here's where things get a little technical but
stay with us because understanding a bit about mitochondria will be helpful in the rest of the
series as we explained how lifestyle factors such as diet exercise stress and sleep impact things
like cellular health and genetic expression and ultimately the aging process and don't worry
we'll unpack these concepts along the way one of the five top theories of aging is called the
mitochondrial theory of aging mitochondria are these ancient bacteria about 2 billion years
ago the cells that are ourselves merged with these mitochondria and we like to tell ourselves
oh we harness them as a power source and they like to tell themselves we found a petri dish
and we're still in charge so within all their cells we have a powerhouse that makes energy
called mitochondria and basically every time we eat foods proteins fats carbohydrates to
make glucose and then glucose combines with oxygen that's circulating as we breathe it and
then we start to make something called ATP which then provides us energy to function and the Hired
mitochondria higher functioning your mitochondria is more ATP you have but if they are weak they are
stressed they cannot turn food and air into energy then it's gonna be harder for you to do what you
want and that's why mitochondria matter for more than just aging if they're happy you're happy if
they're stressed you're stressed the mitochondria in general if I will give a description of
them we have about a hundred quadrillion of them or that's one followed by 17 zeros and
our human body in an average 70 kilogram male has only about thirty point seven times ten to
the thirteen number of cells imagine that these are bacteria that are inside your cells each cell
contains an average of about 500 mitochondria but that's an unfair thing to say because those with
very high energy demands would have about once 1,000 to 2,000 per cell so your mitochondria have
their own bacteria level intelligence and their own goals and agendas which are partly to keep you
alive forever because you're a petri dish but also to make sure you run away from scary things make
sure you eat everything and make sure that you reproduce with everything else and those behaviors
actually can make you old or they can make you young so the mitochondria essentially produce not
only energy for you it's also responsible for the production of what's called the reactive oxygen
species or Ross now reactive oxygen species are signaling molecules at the proper levels and
they signal the nucleus as regards how much energy is being produced they also signal cell
death so these are very important functions of mitochondria so we know it only as an energy
source but it does all of these other things that are actually vital for aging and for good
health well it turns out that we actually have an internal antioxidant defense system and it's not
you know this this whole thing of longevity and resistance to disease isn't a matter of how many
vitamin C and and vitamin A and vitamin E pills you can pop during your life it's a matter of
are you doing the things that actually stimulate your mitochondria and your cells to build up
their internal antioxidant defense system the what's called the a re the antioxidant response
element and interventions like hormesis [Music] actually that's what really builds that system
up and makes it more resilient and what actually reduces oxidative stress at the cellular level
in the long run for mimic stress is interesting and that it in this day and age we try to
avoid stress so much we're told to minimize stress but interestingly whether we place a
human a human child a cat a dog a plant in a completely stress-free environment they don't
actually thrive and so this is true whether we're talking about sunlight exposure or kind of
interesting constituents and plants or what have you it's that stress that actually alerts our
body alerts our system that there's something maybe not quite right and it may actually be a
little bit in the short-term negatively impactful on us but then it causes an upregulation and
everything from antioxidant systems to immune response within military circles they like to
talk about this with regards to resiliency so resiliency the the physics equation for it
is pretty interesting but what it describes is that you can test a system and it will become
stronger as a consequence of the testing and so that's really the basis of hormesis yes we have
certain types of stressors chronic psychological and emotional stress job stress relationship
stress that can potentially be problematic in the long run but we're also missing out on certain
key types of metabolic stressors that are actually critical to health and longevity these things in
small amounts actually confer a pretty profound protective effect so heat cold wild plants and
other wild foods Sun lights and turns out over time as a result of of millennia of being in that
situation our bodies not only learn to cope with that stress but actually evolved in such a
way that we require those types of stressors in order to be healthy and for just for ourselves
to function normally the in terms of acute stress we actually should be able to respond to acute
stress and in order to do that we produce lots more energy and in the process of producing
energy we produce reactive oxygen species at low level reactive oxygen species can play a role
of different types of mediators signal transducers but if oxidative stress is excessive it causes
percolation of lipids damage to DNA to proteins and this if these damages are not repaired
they accumulate the inflammatory response is intended only for acute purposes but when it's
there chronically then we start developing all the chronic diseases like neurologic diseases
neurodegenerative diseases diabetes and other metabolic diseases and even cancers so when we
say inflammatory disease and the free radical and oxidative stress it is automatically the same when
you say this disease is related to my to conjugate dysfunction every chronic illnesses linked to the
mitochondria now you know the chronic fatigue the cancers the you name it I mean let's take the
list was small 15 years ago now exact virtually every chronic illness involves a mitochondria
whereas no disease which has nothing to do with mitochondria I mean if you see a certain
patient with a certain symptoms which remind you of a certain disease file but if something
is off something just doesn't fit the picture of this particular disease think mitochondria
are so we started to really look at this very very seriously in the in the early 90s as to how
this would spread the conditions musculoskeletal problems cardiac problems immune related problems
neurological problems reproductive problems so you have endocrine dysfunctions you have then
obviously carcinogenesis and and oncogenesis and cancer all those can be traced back to aspects
of alteration in mitochondrial function the first time that there was a connection between
human diseases and mitochondrial DNA was made in 1988 when Doc Wallace published his famous
landmark paper in science in each we have hundreds thousands mitochondria and inside each mother
country we have between 5 10 15 and more copies of mitochondrial DNA the number of good mitochondria
versus bad mitochondria is actually an compassed in what a word called heteroplasmy you know Homo
plasma means there's a lot of healthy mitochondria I had a plasma means this means it's a mixed
with some bad manikanta in their mitochondrial DNA when mutated is the basis for mother country
DNA diseases and during the 90s of a number of my the kanto DNA diseases has literally exploded
clinical implications are of is the balance between healthy DNA as a healthy Macondo DNA
in one cell and mutated by the Condor DNA that means the number of mutated DNA has to reach
a certain level when we start seeing clinical symptoms and before we see screening symptoms or
not then thermo depends on the energy demand of tissue this particular mother control is in now
if a task of a tissue is to produce insulin for diabetes and we don't have energy to do that when
we facilitate diabetes if a major function of the tissue is to think do you have imagination and
we don't have enough energy to do so well when you cannot think probably anymore if a major task
of a tissue is to run away skeletal muscles and and you get that lift okay when you so it really
depends on the function of a tissue which is then impacted and and this is also a reason for that
for multitude of symptoms is hugely the rules so what Doug Wallace has demonstrated in his research
is that as mitochondrial DNA mutations occur at higher rates in a given tissue we start to see
disease symptoms show up the more mutations the more severe the symptoms tend to be in that
given organ so it becomes imperative that we protect our mitochondrial DNA from excessive
damage especially in women so there's only one place that baby gets mitochondrial DNA and
that's directly from mom and that's why it is so imperative that as a society we are looking
after women's health if we want to ensure that all of humanity is optimized and on its best
we have got to look after that mitochondrial DNA because that's the lineage that's going to
be passed on the eggs that a woman has today that will become a future baby we're actually
maturing in her mother's body and her mother's eggs were actually maturing in her grandmother's
body so when we say lineage we literally mean the female lineage one of the best ways to look at
the mitochondria from a metaphorical level is to imagine a city in a blackout when a citizen in a
blackout there is no energy to power up anything so one of the things that happens is there is loss
of law and order right so you have runaway cells and you call them cancer cells there is loss of
garbage collection so you have piles and piles of garbage in there and you could see that happens
in Alzheimer's disease so these are the things that happen when you have loss of power or when
you have very many defective mitochondria inside the cell that's unable to power itself as you
get older it has the propensity to produce more and more dysfunctional mitochondria because the
mitochondrial DNA actually mutates very rapidly the body has mechanisms to get rid of those
but as you get older that those mechanisms also become inefficient so there is about that
window that has been talked about in terms of longevity where the mitochondria cannot catch
up anymore in terms of the medical value Genesis and in terms of the number of my token
dysfunctional getting destroyed such that now their body will go into eating and senescence
and as the mitochondria become worse and worse at making food and air and light into energy you
get older and older everyone over age 40 has mitochondrial decline which means we make less
energy from food than we did when we were young and half of us under age 40 have early onset
mitochondrial deficiency what what I think is causing that is lack of hormetic stress in our
lives and when the mitochondria are weakened by this lack of hormetic stress you know think
of if you've ever broken a bone and you've got a cast on you know what happens after you get
that cast off you notice that all your muscles have atrophied right well that's what happens
to mitochondria the inside of your cells when they're not being exposed to hormetic stress they
weaken they atrophy and they lose their capacity to produce energy now when that happens they also
lose their resiliency in the face of stress and it lowers what I call your resiliency threshold which
is this this kind of tipping point it's basically the amount of stress that your body can can handle
and recover from before it starts to go into you know various kinds of symptoms and illness and
disease and accelerated aging and as a result of that you now become much more susceptible to
all these types of stressors in the environment whether it be infections sleep deprivation toxins
anything else and those stressors can now tip your cells into cell danger response mode the cell
danger response is kind of the the newest way or the newest defined way of looking at how
the mitochondria are really functioning to protect the cell and a lot of the early research
on damage associated molecular patterns and damage associated molecular proteins have led to a deeper
understanding that the mitochondria do much more than produce ATP in fact they are now seen as the
primary cellular defense against viruses pathogens and toxins and some of the work that has been done
by researchers like Robert Navi Oh for example has clearly demonstrated that extracellular ATP which
originates from the mitochondrial signaling gets ejected out into the extracellular space in this
extracellular ATP these extracellular purines are essentially becoming key signaling molecules
that will alert neighboring cells to the threat of danger this process of cell danger response
signaling will basically cause the mitochondria to shut down its basic functions as a protective
mechanism the problem with that is if this cell danger response doesn't turn off once the threat
is resolved this leads to dysfunction of the cell and dysfunction of the mitochondria it's now been
established that many chronic diseases including autism spectrum disorders are extraordinarily
linked to this cell danger response signaling it's looking more and more like that problem of
the body getting locked into this cell danger response mode maybe underlies many if not most
chronic diseases many different mechanisms will change in the mitochondria methylation will
then shift away from DNA synthesis towards more promotion of inflammatory mechanisms so
the mitochondria will actually try to use free radicals to fight a virus or a pathogen and
so vitamin D metabolism shifts b6 metabolism shifts purines shift uric acid shifts all of these
different cellular metabolic processes change when a cell danger response is undertaken and normally
this cell danger response will will appear and then it will eventually resolve once the threat
has been eliminated and the person's health will go back to normal but what we now understand is
that some people they cannot shut off their cell danger response and it's stuck on automatic all
of the time and this is believed to be happening in at least one condition the autism condition we
know that according to the research of navi o that the the oldest drug in existence known as sermon
is able to kind of hit the reset button on this extracellular ATP signaling which is intricately
involved in the cell danger response and by administering this micro dosing this this very
old drug once every five weeks or so the the cell danger response has reset in all of the clinical
parameters of autism is significantly improved so there's an enormous amount of potential with
this therapy so if we look at just everything on a cellular level and taking a look sniffing
the DNA and you know correcting for even just correcting for mitochondrial function etc it's a
very short-sighted view because we are organisms that are built on networks upon networks of of
organisms in itself when we look at the Navi or research for example the ATP signaling that's
happening in the cell danger response is outside of the cell and so as we study the intricate
biology of the cell and the intricate genomics and every little thing we are forgetting that
that cell is existing because it's connected to a network of cells and to the matrix that
exists outside of it most recently bacteria and mitochondria have been shown to actually talk to
each other without our knowledge so whereas before we are only looking at things from our point of
control now we are looking at the point of view of the bacterial sense of control and we are
simply its host and as mitochondria is back to a kind of bacteria so the question is who control
mitochondria why mitochondria microbiota [Music] have the share the same characteristic the same
activities in terms of structure and time a term of mechanistic so we asked the question
whether there is a kind of relationship between mitochondria and microbiome certain
concepts are actually blowing up our ideas of what's true you know our current theory of
disease doesn't match the facts the microbiome is the greatest example where we now know that
gut flora can be causing cancer it can cause Anna Cleveland Clinic we have know Kara saying
who's researching the microbiome in breast cancer we have Stan Hazen Singh at the microbiome in
heart disease we have understandings that may be related to dementia or depression or autism
or autoimmune disease or obesity or diabetes and you know how do how do we even frame that
right and you don't go to the rheumatologist with rheumatoid arthritis they go well let me
look at your stool tests and your microbiome right that's not happening yet it will and we
will get there and the convergence of you know some major trends is going to transform medicine
healthcare so when you're looking at longevity you're looking at vitality and I want my body
to be more engaged and alive what we teach this to for functional medicine all the time you also
need to include an evaluation of the microbiome the bacteria of your gut this is the organ that
controls everything your microbiome I mean the guy is at the center of our health I mean this
has been known for thousands of years by ancient healing traditions and we're just discovering
now we thought you know your poop was just your poop but now we're understanding that you know
there are more molecules from microbes in your gut in your bloodstream than your own human
molecules so you are officially you know far more than just yourself the gut is one of the
most important part of our body and it plays a significant role in the immune function the main
reason is one of the most important cells of the immune system which rag relates the immune
system are in the epithelial tissue [Music] I'm sure you know or many people know that
the 70% of the immune system is in the gut actually and so therefore the communication
of the immune system or cells involved in the immune system with the environment of the gods
meaning the microbiome and food is playing a significant role in our overall health we still
have a lot to learn about how they communicate how they control and affect our health before
we could actually say okay this is what we're going to do in terms of definitely increasing
our lifespan or this is what we're definitely going to do in order to prevent disease so when
you change your diet and change your microbiome that changes all your gene expressions if it
costs exposed to chemicals that changes your gene expression or higher genes activate in
turn on turn off our genes are not actually controlling our biology in the way that's
been thought for a very long time they're not the most upstream thing actually the most
upstream thing is the environment you know a lot of people think they're just like dealt this
this deck of cards that spells doom for them once they test their genetics that says they've
got whatever do in my case where I higher the normal risk for type 2 diabetes or higher than
normal risk for prostate cancer and the the fact is that there's a wide variety of things that
go way above and beyond just your snips and your markers from a genetic standpoint that
influence whether or not those those issues are actually going to manifest many people think that
a gene if we have bad genes from our parents that were screwed we're in trouble but that's not the
case because just because that gene is there and it might be posing a problem you have to turn it
on so science is clearly shown now that genes do not dictate our future it's a genetic expression
that actual makes the difference of who we are at any given point in time our genes themselves
actually have no function it's what actually brings them to life that makes the difference your
genes don't determine whether you get a disease or not your genes determine whether you're vulnerable
to getting a disease or not it's the weak link in your chain so as we know we have nuclear DNA and
we have mitochondrial DNA and they're not the same mitochondrial DNA are only maternally inherited
our nuclear DNA are inherited from both parents but there's a crosstalk that's happening between
how our cells function how ATP is getting made and how our DNA is actually communicating in a
sense to our mitochondria who have found lately that there is there are communication channels
between the mitochondria and then in the cell nucleus so what happens the mitochondria releases
some molecules that go in with the nucleus and make our genome react to what's happening I
mean the reality is that you know we have DNA DNA is like an instruction manual it's a gigantic
instruction manual that is supposed to say here's how the body is this body is supposed to operate
given the circumstances what you've inherited but that DNA has to be translated into RNA and RNA
has to be translated into a protein which is what you actually use so there can be all kinds
of potential problems that are happening in the DNA to RNA to protein translation process that we
really don't have a good enough grasp of yet but we can suspect based upon the initial research
that environmental factors really do have a role to play in influencing all of these things to
me a gene is simply it's a book to be read so a gene has a job to do and we have about 19,000
different genes and they all do some do one job and some do multiple jobs and so if the gene is
told that it needs to turn on then it will do it and things that will tell a gene to turn on could
be infections it could be your mindset if you get irritated or pissed off you're firing a lot of
genes to stimulate you so you can take action we have the lately as a new term in biology has
been born which is called epigenetics it's from the Greek word epi which means above genetics so
someone is born and most of us are born healthy there is only one in case in 2500 cases it has
any inborn error of due to two problematic genes but there is 2499 of us are born healthy so what
we do after our birth which is a pigeon ethics is that influences is our health and this is the
most important part of your genes are only poor in the picture how you change them or express them
through the things you do in your life really make all the difference and when you look at these
genes studies no there's no question that an environmental factor a diet lifestyle nutritional
factor plays a role in who you become the classic example in the best models to say that or
twin studies because they share very similar genotypes identical twins have the exact same
genetic makeup yet over time they become very very different people because their environments
their lifestyles the food they eat the jobs they do the people they hang out with environments and
climates they choose to live in they become very very different people purely based on their
epigenetics you know when you look at us twin studies that on smokers and non-smokers that
person looks at dramatically different now you know somebody who's smoking probably if if we dig
a little bit deeper there might be an emotional component to why they're still smoking and so that
could be what's aging them more so than the actual cigarettes might be aging them so it's really
hard to study no human beings the way we would study lab rats or the way we'd study microbes in
a petri dish because there's so many layers of complexity to the human life span that it's hard
to say it's one particular thing but we certainly know that they have the same genes being twins and
the environments and conditions that they were and in the decision that they made altered how they
look and probably how they think and how they function so when different factors accumulated
great damage at the cellular or biological level these caused our cell to multiply actually the
sting cells the cells the the mother cells that can multiply and replace all there or dam itself
that they have to multiply but it's time they multiplied a part of the of the outer part of the
chromosome which is called the last part in Greek is called tellers last and part marrows they are
called telomeres they become shorter because the last part is not copied when the the telomeres
get shorter the DNA in the genome which the genome is the information contained within the DNA and
the chromosomes becomes unstable so when we have unstable DNA we are open to diseases already been
death or because the DNA doesn't function well the shorter our telomers the Moral the old Rugel at
a biological level in terms of aging one of the indicators that have been given out recently was
telomere length and actually you know a reactive oxygen species damaged telomeres so you should
take a look at what damages your telomeres first so that takes precedence over looking at the
telomere length itself so it's a longer view to take a look at the mitochondria first before you
actually attribute all of these other downstream changes like in cancer or in telomere length to
the actual mutations in them or the decreasing function in them and shifted more towards how
much energy are we providing for the continued maintenance and function of these particular
enzyme systems now the conversation about at telomeres which is the ends of our genes was very
interesting about a decade ago we studied and found those shortened with age this is something
we got excited about and we understand now it's far more about our environmental lifestyle factors
the influence our genes that actually cause them to either shortens more slowly less slowly or
actually start to reverse in that deterioration process telomeres are maintained by telomerase
you know as a somatic system that is believed to have a decreased function over time but why does
it decrease function over and you could take a look at that most probably there's increased
damage from reactive oxygen species and less protection because of decline in energy production
of mitochondria and besides all their mitochondria if your do not replenish them enough will produce
reactive oxygen species also that will damage the luminaires further so the way of life we do the
diet the stress the environment influence the degree of damage and the degree of the how fast
or how slow our telomere shortening epigenetics our environment and lifestyle the foods we eat
the way we move our body the people that we hang out with the things we think all these dictator
health status at any point in time and we can change those we can change our health status
at any important time we can choose what food we put in our mouth we can choose when we move
our body and how we move it we can choose who we hang out with and we choose how much sleep we
get and how we think about things around us the only thing we're left to conclude is that health
more than anything else is actually a skill set and the moment people understand that and really
have processed it the moment I think this concept of personal responsibility taking ownership will
begin to sink in make sense and induce people to action we normally only become proactive in
our health when there's something wrong with us and you know I think that actually makes sense
because sometimes a person's not ready to change their diet or change their bad ways until they're
sick and tired of being sick and tired they have to get to the end of the rope before they make
a change sometimes that's just the way that it is but it's a lot more intelligent to say let's
improve our health so that we don't make disease processes able to penetrate into our body if
we did that we'd be able to prevent so many diseases today according to a study by Paul
Marston from the University of Sussex called mimetics and social contagions Marston suggests
that when faced with a variety of different options decision-making ability is to simply go or
what is everyone else doing great I'll do that too and so because of this we blindly follow the rules
from generations pass but the problem is the world is changing faster than these rules are change
today things change so fast that the rules from our parents the rules from a society that will
show my religion often no longer apply the way that we are trained in conventional medicine is
is based on about 300 years of cultural history and scientific concepts that tell us that problems
can be fixed through application of force and if it's not working do more force more you know apply
more to the failures of the initial intervention and so this is how we have literally half of
Americans on psychiatric medications how we have one in four women of reproductive age taking
antidepressants well we're really socialized in medicine in America at least as patients to think
that the doctor has an answer for us and that the doctor also has a bottle with a solution for us
or a procedure that will fix us and so that is misleading I can remember one time I went and
googled the term sick healthy just to see what this oxymoron would would produce and I went over
to the images and what you find is is all kinds of books and apps and propaganda essentially designed
to convince us of the reduce ridiculous oxymoron that we can be sick and healthy at the same time
so you get books like how to be sick well how to be well with chronic disease live healthy with
chronic disease I mean craziness think about it by far the most profitable state if you're
the healthcare industry to keep a person in is chronically ill it's it's second to healthy third
to dead Dead's not profitable healthy's minimally profitable chronically ill is a very profitable
state to keep a population in the majority of the costs in the medical system three point three
trillion dollars is generated after the rillette the referral from the primary care doctor so now
you're with an endocrinologist and you're with a you know gastroenterologist and you're with
a hematologist and all these people are very specialized very expend bill your insurance a
lot the labs are expensive that the procedures are expensive the drugs are expensive and so the
best way for us to contain the cost both for the individual for every pair for the individual for
business and for governments is to go upstream and prevent those things from happening for me
the future of longevity is about keeping that ancient wisdom going but using the best bits of
modern science to enhance it that's where we've gone wrong we've got modern medicine getting
into conditions that worthy it does at least get involved with we should let it concentrate
on the stuff that has been life saving that has helped increase life expectancies we need a lot
more humility and medicine like we think we know at all but I mean we're just now discovering
new organs that we never knew exist to me I'm like that's pretty profound to know that you
know we would nice acting the human body for a long time and we still Bo are finding new
things we know so little I mean we progress a lot but we still know so little about what
is it that makes us and whether or not we do really own our body you know or it's someone
else or something else that's actually running us we think that we've created some kind of
you know answer to longevity but truly it's an indigenous cultures that we see longevity
without all these fancy pharmaceuticals and different kind of manipulations to get there
they're living simply but they're living for a long time and truly the things that keep you
out of the doctor's office and that really is the Fountain of Youth secret to life they're not
sexy they're nothing that science is ever going to show us is new they're the basic things that
our ancestors have taught us through the years and really what we've we've lost in Western
society maybe I've got a couple cool golden nuggets of things I can share clinically that
I've done to reverse my health problems and reverse other people's health problems but what
about people that don't have health problems in the first place what are they doing that we're
not doing I think there's other puzzle pieces out there that we just truly understand yet and
if we go study these people will further gone we've got a good chance of of really setting
the tone for the future you know it's funny we thought the same thing so we did it in the
spring of 2017 we traveled around the world to find out what we can learn from those who appear
to be aging successfully without chronic disease there are these pockets of people that are
supporting each other that know each other's families that have each other's backs they're
intimately involved with the plants they're intimately involved with each other when someone
is stressed when someone's having a challenge they all band together they help each other
they laugh a lot they have fun they know how to take life too seriously all these things
are important health just seems to happen to these folks in a very natural way they live in
communities they're in relationships with people they don't stress out about small things
my guess would be they're not so attached to being on iPhones and iPads and computers my
guess would be they're not on Facebook trying to prove defend get their needs met and they
have a much deeper feeling of acceptance from themselves and everyone that's around them they
don't think about health health is the default option for them by virtue the way that they
choose to live our lives only Susannah stay at the Frisco astrology only ones dependents
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said we're going whatever your isn't it you know game with the parameter isn't easy being
in total offense Bob lemon eternal night is put of you gentlemen to Ferrari all right what are all
these people doing they're all living very similar lifestyles and what they're doing is they're
living on this planet the way we evolved to live on this planet you know conozco sorbet chibi
me not to that and carelessly put AC Anjali is so low quality print capital Indian companion imagine
a deep a newborn or can only see steep you in the supermarket Elektra cheetah non trader the pr2 toe
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the novelty a year very a and and already - no you listen to me pero cuando ella la finca tatin
mo every machete on of toes and uma Tony nope in sanik a look Anderson lamented Oh nos Falcons and
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thousand ago represent a chasm and I'm a pig or a human a marketer holiday the ethnicity sure
nothing cannot imagine so now take a value so naughty and that's that's alien seven my Laura
a row naughty he made a report for duty under sahih bukhari madman the very remain a familiar
one do your part to them to level with quality you know johnandrich when you see peridot at
what Villa who are not one liquid or gravity the dimension talked to Julie but people on
the team could increase their revival a okhla I was with us yo our central real vigilante on
oh these are reversible general chatter speed Elsa - Aldo metal demonic you know such a such
a traditional religion technical analysis such the caracal generators were born the kids believe
religion the backdrop on peridot blue car I think when we're pursuing this journey of longevity
we have to find something to live for we have to find our purpose and our purpose might be to
find our purpose that might be our initial purpose otherwise I think the pursuit of longevity is just
a fancy way of saying I'm scared of death if we were taught death is this beautiful life is this
beautiful story here on earth the natural cycles we would just the same not have as much fear and
or shame around what death represents to us how they don't know families will make people whole
get off your own body by now yes I mean I know I'm I'm going where everyone else is going can
I maximize the time either be at the time and the relationships with the people close to me the
food that I eat the experiences that I have are we running from death or are we chasing health and
this to me is a pivotal and imperative question to answer I do not think that death is an avoidable
tragedy and that's how we treat it in the West we treat death like is an avoidable tragedy but if
we're looking at longevity as a means by which to optimize our life to optimize our health to start
living more in accordance with nature then this seems like a very worthwhile pursuit you know one
of these people often don't realize is that we're biological organisms and then we have to follow
the laws of nature that we you know we wouldn't feed our dogs things that we feed ourselves right
but we feed them do our kids and we try to ignore the limits of our human biology and not tend to
the things that are gonna create health I don't think longevity in and of itself is a core value
quality of life is a core value and that has many elements oh one of which is health why don't
you tell you that either you're looking this is it dose it's really easy to rack up a score
and say look I live till this number but what does that mean empty years or empty years right
and so were they filled with passion where they filled with time with family and loved ones
what was your purpose what were you doing did you enjoy the sunshine did you move around like
you wanted to and so these types of things are way more important than this idea of longevity just
extending life for just that reason our primary focus instead of longevity I should be happiness
because that happy is the key to longevity versus the opposite living longer won't make you happy
but being happy will allow you to live longer who cares if I can extend a telomere if I don't smile
laugh giggle and enjoy every moment of my life every day the goal really in our life when you
look at everything we try to accomplish is to try to be like a child you just try to be completely
satisfied in your life know that your needs are gonna be met have complete confidence in who you
are be in love with who you are who you what you look like not wanting to change a thing look
in the mirror and just enjoy yourself children do that we're always trying to get back to that
state of a child when we get back to the state of a child now that youthful glow that joy that
laughter that energy that attracts us to human to human anyway is now all culminated within our body
and that truly is what propels us into longevity I hope you enjoyed episode 1 of the human
longevity project as we took a deep dive into mitochondrial health mitochondria clearly play a
primary role in the aging process by communicating with our microbiota and our DNA to control genetic
expression so the question is how do we keep our mitochondria healthy as this series progresses
you'll find out how lifestyle factors like diet exercise light toxins emotions community and
purpose all affect mitochondria to impact your state of health and what you can do to live a
happier healthier and more harmonious life the health issues we're now facing are impact on our
children like never before and because of this we've made it our mission to reduce the number
of birth related deaths worldwide we're aiming to impact the lives of 1 million children over
the next several days you'll hear more about this mission and our plan to accomplish it but we need
your help your involvement your voice and your passion are critical please continue to spread
the word by hitting the share button below and help us grow this movement together we can create
a brighter future for all of us thank you [Music] [Music]
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