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DNA Joker Overview

Jun 8, 2025

Overview

DNA is a rare Effect Joker in Balatro available from the start, allowing players to permanently duplicate a card when only one is played as the first hand of a round. Its effectiveness depends on deck, hand, synergy with other Jokers, and playstyle.

DNA Joker Details

  • Effect activates if the first hand of a round has only one card, permanently adding a copy to the deck and drawing it immediately.
  • Rarity: Rare; Type: Effect Joker; Activation: On Played.
  • Available from the start; buy price $8, sell price $4.
  • Compatible with Copyable, Perishable, and Eternal stickers.
  • Best used with strategies focused on duplicating high-value cards.

Synergies

Deck Synergies

  • Blue Deck: Extra hand allocation favors DNA’s single-card copy effect.
  • Red Deck: Additional discards increase odds to find desirable cards for copying.
  • Black Deck: Fewer hands discourage suboptimal DNA use.
  • Erratic Deck: Enables easy creation of Flush House or Flush Five hands via DNA.

Poker Hands

  • DNA works best with High Card and strong duplicate-heavy hands (Four of a Kind, Five of a Kind, Flush Five, Flush House).
  • DNA is less effective for Straights and Straight Flushes due to difficulty in duplicating run cards.

Joker Synergies

  • Hologram, Blue Joker, Blueprint, Brainstorm, and Trading Card offer direct or indirect benefits from DNA’s duplication.
  • DNA supports Jokers that require specific cards (Steel Joker, Vampire, Baron, Stone Joker, Shoot the Moon, Driver’s License, Glass Joker, Lucky Cat).
  • DNA has anti-synergy with Erosion, as additional deck cards lower Erosion’s benefit.

Blind Interactions

  • The Needle and The Mouth restrict DNA use due to hand limits or hand-type restrictions.
  • The Psychic disables DNA by requiring five cards to play.
  • The Pillar debuffs DNA-created copies, negating card enhancements.
  • Blinds disabling cards in deck do not prevent DNA from creating duplicates.

Trivia

  • DNA is one of only three Jokers that add cards to the deck (with Marble Joker and Certificate).
  • Card art references real-life DNA’s double-helix structure.

Localization

  • Known as "DNA" in most languages; "ADN" in French and Spanish.