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The History and Impact of Lobotomy

May 5, 2025

Lobotomy: An Overview

What Is Lobotomy?

  • Lobotomy is a surgical procedure performed on the brain, targeting the frontal lobe.
  • Involves making holes in the skull, removing some brain tissue, and severing connections between the frontal lobe and the thalamus.
  • Pioneered by Portuguese scientist Egas Moniz, who was awarded the Nobel Prize in 1949 for this work.

Purpose of Lobotomy

  • Intended to provide relief for mental illnesses unresponsive to standard treatments.
  • Used primarily in the 1940s and 1950s when psychiatric treatment options were limited.
  • Conditions treated included schizophrenia, affective disturbances, OCD, severe depression, psychosis, and manic depressive psychosis.

Procedure Details

  • Surgery aimed to sever nerve fibers between frontal lobe and thalamus.
  • Various methods were used: brain cannulae, leukotomes, chemical injections, electrocoagulation, and ultrasonic waves.
  • Results showed some success, with 44-46% of patients released from hospitals in studies from the US, Canada, and UK.

Historical Context

  • Emerged in the 1930s due to overcrowded mental asylums and lack of effective treatments.
  • Seen as a hopeful solution, allowing some patients to return home.
  • Dr. Walter Freeman popularized the procedure in the US, developing the transorbital approach via the eye socket.
  • Controversial due to severe side effects and ethical concerns about altering personality.
  • Fell out of favor with the advent of psychiatric medications in the 1950s.

Side Effects

  • Brain operations are risky due to the organ's delicate nature.
  • Known side effects include bleeding, infection, dementia, intellectual impairment, epilepsy, apathy, incontinence, obesity, and death (2% mortality rate).

Modern Practices

  • Today's psychiatric surgeries are more precise and less damaging.
  • Use of advanced imaging techniques like CT, MRI, and EEG to guide procedures.
  • Stereotactic neurosurgery is used for intractable pain, epilepsy, movement disorders, and resistant mental health disorders.
  • Procedures like cingulotomy and deep brain stimulation offer more predictable outcomes.

Conclusion

  • Lobotomy marked a significant, though controversial, chapter in psychiatric treatment history.
  • Modern techniques have evolved to provide safer and more effective options for treatment-resistant conditions.