The Science Behind ADHD, MTHFR Gene, and Diet

Introduction

• Topic: Science of ADHD and the MTHFR gene, and the role of diet in managing symptoms
• Speaker's Experience: Personal struggle with ADHD for decades
• Purpose: Explore link between genetics, diet, and ADHD

ADHD and MTHFR Gene

• ADHD: Attention Deficit Hyperactivity Disorder affecting daily reality
• MTHFR Gene: Methylene Tetrahydrofolate Reductase
  • Responsible for converting folic acid and its derivatives into methylfolate
  • Critical for DNA production, repair, and neurotransmitter synthesis

Role of MTHFR Gene

• Influences methylation process
  • Involves transfer of methyl group (1 carbon and 3 hydrogens)
  • Affects DNA production, gene expression, detoxification, etc.
• Variations in MTHFR gene can affect folate metabolism
  • Impacts neurotransmitters like dopamine and serotonin
  • Critical for mood regulation, focus, and controlling impulsivity

Managing ADHD through Diet

• Folate-Rich Foods: Leafy greens, legumes, fruits
  • Support brain health
• Omega-3 Fatty Acids: Found in fatty fish (salmon, mackerel, sardines)
  • Supports cognitive function
• Limit Folic Acid: Synthetic form of folate found in fortified/enriched foods
  • Remove for 7 days to test impact on ADHD symptoms
• Foods to Avoid:
  • Processed foods with additives and preservatives
  • Artificial colors are proven antimicrobials
  • High sugar intake
  • Non-organic coffee (due to mold toxicity and formaldehyde)
• Caffeine: In moderate amounts, beneficial
• Whole Grains: Qunioa, brown rice, oatmeal (non-enriched, non-fortified)

Supplementation

• Hydrogen Water: Reduces inflammation, improves absorption
• Perfect Amino: Full-spectrum amino acids for muscle recovery and exercise performance

Specific Recommendations

• High EPA/DHA Omega-3s: Found in fatty fish, improve brain health
• Avoid Quercetin: In green tea if COMT gene mutation is present
• Monitor Alcohol Intake: Negative impact on people with MTHFR deficiency

Research & Studies

• 2018 Meta-Analysis by Goo et al.: MTHFR polymorphisms associated with higher ADHD risk
• Supplementation of Trimethyl Glycine and Methylfolate: Reduces ADHD symptoms

Conclusion

• Complex Intersection: Genetics, nutrition, and brain health
• Proactive Steps: Dietary strategies can manage ADHD
• Final Note: Stay curious and healthy