Lecture Notes: Medication Monday - Ondansetron (Zofran)

Instructor Introduction

• Instructor Name: Stacey
• Role: Paramedic Instructor
• Session Theme: Medication Monday

Overview of Ondansetron (Zofran)

• Brand Name: Zofran
• Drug Class: Antiemetics
• Type: Serotonin receptor antagonist

Mechanism of Action

• Receptor Target: 5-HT3 receptors
• Action: Antagonizes 5-HT3 receptors to block serotonin
• Location of Receptors: Brain and GI tract
• Effect of Serotonin: High serotonin levels can cause nausea and vomiting
• Purpose of Zofran: Prevent further nausea or vomiting by blocking serotonin

Indications and Contraindications

• Indications:
  • Nausea
  • Vomiting
• Contraindication:
  • Long QT syndrome

Dosage and Administration

• General Advice: Follow local protocol and stay within scope of practice
• Typical Adult Dose: 4 to 8 milligrams
• Administration Methods: IV, IO, IM, PO
• Pediatric Dose: 0.15 milligrams per kilogram

Side Effects

• Common Side Effects:
  • Dysrhythmias
  • Headache
  • Constipation

Special Considerations

• Pregnancy:
  • Generally safe for hyperemesis and severe morning sickness
  • Check local protocol for specific guidelines
• Alternative Medication:
  • Diphenhydramine (Benadryl) may be recommended

Discussion and Personal Experience

• Effectiveness:
  • Some debate about its effectiveness as an anti-emetic
  • Personal experience shows efficacy in treating nausea
  • Less effective for vomiting
• Audience Interaction: Stacey asks for others' experiences with Zofran

Closing Remarks

• Summary: Coverage of Zofran's uses, dosages, effects, and special considerations
• Engagement: Encouragement to share personal experiences with the medication