Huberman Lab Podcast: Cannabis Discussion with Dr. Matthew Hill

Introduction

• Host: Andrew Huberman, Professor of Neurobiology and Ophthalmology at Stanford School of Medicine
• Guest: Dr. Matthew Hill, Professor of Cell Biology and Anatomy at the University of Calgary
  • Focuses on the effects of cannabis on stress, feeding, and behavioral impacts.

Background of the Episode

• Originated from a debate on social media about Andrew Huberman's previous podcast episode that discussed the potential harms of cannabis, particularly psychosis and strain differences (Indica vs. Sativa).
• Dr. Hill criticized some points, leading to an invitation to discuss on the podcast.

Main Topics Discussed

Biology and Mechanisms of Cannabis

• Cannabis Plant: Contains multiple cannabinoids, with Delta-9-THC (THC) being the primary psychoactive component and CBD being another well-researched component.
• Cannabinoid Receptors (CB1 and CB2): THC acts primarily on the CB1 receptor, which is prevalent in the brain.
• Endocannabinoids: Anandamide and 2-AG serve as endogenous ligands for CB1, maintaining neural homeostasis.

Effects of Cannabis

• Psychoactive Effects: Euphoria, altered time perception, increased appetite (known as