Huberman Lab Podcast: Discussion on NAD and Longevity with Dr. Peter Attia

Introduction

Host: Andrew Huberman, professor of neurobiology and ophthalmology at Stanford School of Medicine.
Guest: Dr. Peter Attia, a medical doctor specializing in healthspan and lifespan.
Main Topic: NAD pathways as a potential target for improving lifespan.

Overview

Discusses NAD pathway and its significance in longevity.
Compares different molecules and methods for increasing NAD levels: NR, NMN, direct infusions, and oral NAD.
Framework for thinking about longevity: mTOR pathway, rapamycin, Metformin, and fasting.

NAD Pathway

NAD (Nicotinamide Adenine Dinucleotide): Critical molecule for energy production, found in almost all cells.
Role of NAD: Involved in electron shuttle for energy metabolism and DNA repair.
Decline with Age: NAD levels decline with age, sparking interest in supplementation.

Key Molecules and Methods

NR (Nicotinamide Riboside): Precursor to NMN, can cross the cell membrane directly.
NMN (Nicotinamide Mononucleotide): Precursor to NAD, must convert to NR to enter cells.
Direct NAD Infusions: More direct method, but expensive and uncomfortable.

Supplementation vs. Natural Ways

Exercise, Sleep, Nutrition: More effective than supplements; foundational approach to health and longevity.
Supplements Discussed: NR, NMN, Rapamycin; skepticism about over-the-counter NAD precursors for longevity.

Evidence and Studies

NAD and Healthspan: Limited evidence on lifespan extension in humans.
Interventions Testing Program (ITP): Found no significant lifespan extension from NR.
Potential Benefits: Some studies suggest NR/NMN may reduce skin cancer risk (squamous and basal cell).

Other Considerations

Cost and Commercial Interests: NR is FDA-approved as a supplement, NMN is not.
Health Practices: Importance of behavioral health interventions (exercise, diet) over supplements.

Conclusion

Takeaway Message: Focus on proven methods like exercise and nutrition for longevity.
Supplements: Can be part of a health regimen but should not replace foundational lifestyle practices.

Personal Regimens

Peter Attia: Takes Rapamycin, fish oil, vitamin D, magnesium, and other targeted supplements.
Andrew Huberman: Takes AG1, fish oil, vitamin D, creatine, and other health-focused supplements.

These notes provide a summary of the key topics and discussions from the podcast episode on NAD and Longevity with Dr. Peter Attia and Andrew Huberman. They cover the scientific basis, experimental evidence, and practical considerations for NAD supplementation and its role in health and lifespan. The emphasis is on understanding NAD's potential and limitations, advocating for essential health behaviors as the primary means of longevity.

NAD, Longevity, and Healthspan Insights