🧠

Neurobiology of Grief

Sep 5, 2025

Overview

This lecture explains the neurobiology of grief, exploring how our brains process attachment, loss, and adaptation to the absence of loved ones.

The Brain's Representation of Absence

  • The brain creates a mental map or "virtual reality" of expected surroundings and relationships.
  • Absence is felt because our expectations (mental map) clash with the new reality.
  • Grieving involves learning to reconcile the difference between expectation and reality.

Neurobiology of Grief and Attachment

  • Grieving is prolonged because our brain maintains two conflicting streams: knowing the person is gone, and feeling they're still present.
  • The hippocampus handles memories of loss, while attachment systems foster enduring bonds.
  • Attachment bonds are formed with a belief in everlasting presence, which persists after the loss.

Animal Studies and Human Grief

  • Prairie voles, which mate for life, show brain changes when bonded or separated.
  • Epigenetic changes in the nucleus accumbens region support long-term bonds.
  • Separation decreases oxytocin (bonding hormone) activity in the nucleus accumbens.
  • In humans, yearning for a lost loved one correlates with activation in the nucleus accumbens.

Grief as Learning and Adaptation

  • The brain is generally good at learning absence but struggles when strong attachments are involved.
  • Grieving people often feel as if the lost loved one is still present due to slow adaptation.
  • Predicting absence rather than presence requires time and repeated experiences.

Continuing Bonds and Moving Forward

  • Continuing bonds: ongoing, felt connection with the deceased through memory, conversation, or meaningful events.
  • Attachment systems allow for continued connection with those lost and for forming new bonds.
  • The brain helps restore a sense of meaning and possibility in life after loss.

Key Terms & Definitions

  • Virtual Reality (of the Brain) β€” The brain’s internal map of expected surroundings and people.
  • Attachment Neurobiology β€” Brain systems that create and maintain emotional bonds.
  • Nucleus Accumbens β€” Brain region involved in bonding and grief responses.
  • Oxytocin β€” Hormone linked to bonding and attachment.
  • Epigenetic Change β€” Long-lasting modifications in gene expression due to bonding experiences.
  • Continuing Bonds β€” Ongoing sense of connection to a deceased loved one.

Action Items / Next Steps

  • Reflect on your own experiences of loss and grief as part of learning.
  • Engage in conversations about grief to better understand and normalize the experience.