Understanding Cellular Energetics in Biology

May 1, 2025

AP Biology Unit 3: Cellular Energetics

Introduction

  • Focus: Cellular energetics, including cellular respiration and photosynthesis.
  • Topics covered: Enzymes, cellular energy & ATP, photosynthesis (light reactions & Calvin cycle), and cellular respiration (glycolysis, link reaction, Krebs cycle, electron transport chain).
  • Presenter: Glenn Wokenfeld (Mr. W), retired AP Biology teacher.
  • Resources: Checklist at AP bios.c/checklist, Learn-Biology.com AP Bio curriculum, BiomMania AP Bio app.

Enzymes (Topics 3.1 to 3.3)

Properties of Enzymes

  • Nature: Most enzymes are proteins, some are RNA.
  • Function: Catalyze reactions by lowering activation energy.
  • Specificity: Highly specific, with active sites complementary to substrates.
  • Structure: Composed of secondary, tertiary, and quaternary structures with hydrogen/ionic bonds.
  • Environmental Impact: Denatured by changes in pH, temperature, or ion concentration.

Enzyme Activity

  • pH Changes: Most enzymes have an optimal pH; performance drops outside this range due to bond disruption.
  • Temperature Changes: Activity increases with temperature until a peak, beyond which denaturation occurs.
  • Substrate Concentration: Increases reaction rate until saturation point is reached.

Inhibition

  • Competitive Inhibition: Molecule competes with substrate for active site.
  • Non-competitive Inhibition: Molecule binds to allosteric site, altering active site shape.

Cellular Energy (Topic 3.4)

Metabolic Pathways

  • Definition: Series of enzyme-catalyzed reactions.
  • Types: Linear (e.g., glycolysis) and cyclical (e.g., Krebs and Calvin cycles).

Autotrophs vs. Heterotrophs

  • Autotrophs: Produce their own food (e.g., plants via photosynthesis, some bacteria via chemosynthesis).
  • Heterotrophs: Obtain energy from organic compounds produced by other organisms.

Exergonic vs. Endergonic Reactions

  • Exergonic: Releases energy (e.g., cellular respiration).
  • Endergonic: Requires energy input (e.g., photosynthesis).

ATP

  • Structure: Ribose sugar, adenine, three phosphates.
  • Function: Powers cellular work; ATP synthesis and breakdown store/release energy.

Photosynthesis

Overview

  • Process: Converts light energy into chemical energy (glucose) using CO2 and H2O.
  • Equation: 6 CO2 + 6 H2O + light energy → C6H12O6 + 6 O2
  • Type: Endergonic reaction.

Evolution and Consequences

  • Evolution: Evolved ~3.5 billion years ago.
  • Consequences: Produced oxygen-rich atmosphere, enabled aerobic metabolism and life on land.

Phases of Photosynthesis

  • Light Reactions: Occur in thylakoid membranes, produce ATP and NADPH through photoexcitation and electron transport.
  • Calvin Cycle: Occurs in stroma, fixes CO2 into carbohydrates using ATP and NADPH.

Cellular Respiration

Overview

  • Process: Converts glucose and oxygen into ATP, CO2, and water.
  • Equation: C6H12O6 + 6 O2 → 6 CO2 + 6 H2O + ATP
  • Type: Exergonic reaction.

Phases

  • Glycolysis: Occurs in cytoplasm, anaerobic, yields pyruvate, ATP, and NADH.
  • Link Reaction: Converts pyruvate to acetyl CoA, produces NADH and CO2.
  • Krebs Cycle: Occurs in mitochondrial matrix, produces ATP, NADH, FADH2, and CO2.
  • Electron Transport Chain: Occurs in mitochondrial membrane, uses NADH/FADH2 to produce ATP.

Anaerobic Respiration and Fermentation

  • Difference: Aerobic uses oxygen and produces more ATP; anaerobic occurs without oxygen, limited ATP (2 per glucose).
  • Fermentation Types: Alcohol (yeast) and lactic acid (muscle tissue), regenerate NAD+ for glycolysis continuity.

Conclusion

  • Utilize resources like learn-biology.com for better comprehension and preparation for exams.
  • Next steps include studying Unit 4 on cell communication, division, and feedback mechanisms.