GP2B3A Inhibitors: A Study Guide

Introduction to GP2B3A Inhibitors

• Class of blood thinners.
• Includes medications: abciximab, tyrophaban, and eptafibetide.

Mnemonic for GP2B3A

• Grand Prix on lap 2 out of 3 helps remember GP2B3A.
  • GP from Grand Prix.
  • 2B3A from lap 2 out of 3.

Mechanism of Action

• GP2B3A (Glycoprotein 2B3A) is on platelet surface.
• Inhibitors block this molecule to prevent platelet plug formation and blood clotting.

Drugs Overview

• Abciximab
  • Mnemonic: ABC blocks.
  • Most common GP2B3A inhibitor.
• Tyrophaban
  • Mnemonic: Tyrophaban Tyrannosaurus.
• Eptafibetide
  • Mnemonic: Epitaph.

Clinical Uses

• Anti-platelet drugs symbolized by "falling plates".
• Prevent platelet clumping, crucial for:
  • Coronary artery stenting.
  • Coronary emergencies like unstable angina and myocardial infarctions.

Side Effects

• Main side effect: Bleeding.
• Symptoms include:
  • Hypotension and tachycardia.
  • Tarry stools or blood in urine.
• Recommendation:
  • Avoid unnecessary invasive procedures.
  • Monitor hemoglobin and red blood cell levels closely.

Recap

• GP2B3A inhibitors (abciximab, tyrophaban, eptifibatide) prevent platelet aggregation.
• Useful in coronary procedures and emergencies.
• Monitor for bleeding risks.

Conclusion

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