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History of Anti-Vaccination Movements

Jul 22, 2025

Overview

This lecture explores the history of anti-vaccination movements from the early 1800s to recent decades, detailing key controversies and social responses in England and the United States.

Early Vaccine Opposition and Smallpox

  • Vaccination began with Edward Jenner’s cowpox experiments in the early 1800s.
  • Public criticism arose from sanitary, religious, scientific, and political objections.
  • Many objected to smallpox vaccines due to perceived risks, religious beliefs, distrust of medicine, and threats to personal liberty.
  • England’s Vaccination Acts of 1853 and 1867 mandated smallpox vaccination, sparking organized resistance and formation of anti-vaccination leagues.
  • The Leicester Demonstration March of 1885 drew up to 100,000 anti-vaccinators protesting compulsory vaccination.
  • In 1898, the UK included a conscientious objector clause in its vaccination law, allowing exemptions.

Anti-Vaccination Movements in the United States

  • The Anti Vaccination Society of America was founded in 1879 after British activists influenced US sentiment.
  • American anti-vaccinationists formed leagues and pursued legal action to overturn vaccination mandates.
  • In Jacobson v. Massachusetts (1905), the US Supreme Court upheld states’ rights to enforce compulsory vaccination during disease outbreaks.

DTP Vaccine Controversy

  • In the 1970s, concerns arose globally about neurological side effects from the DTP (diphtheria, tetanus, pertussis) vaccine.
  • Publicized case reports and media coverage caused a decline in vaccination rates and outbreaks of whooping cough.
  • UK and US studies found very low risk of neurological harm, supporting continued immunization.
  • Victim advocacy groups formed, but courts did not accept claims of vaccine damage due to lack of evidence.

MMR Vaccine and Autism Controversy

  • In 1998, Andrew Wakefield suggested a link between the MMR (measles, mumps, rubella) vaccine and autism.
  • Intense media coverage caused public confusion and vaccine hesitancy.
  • Wakefield’s research was later discredited and retracted for scientific fraud and conflict of interest.
  • Multiple studies found no link between MMR vaccination and autism.

Thimerosal and “Green Our Vaccines” Movement

  • Thimerosal, a mercury-containing preservative in vaccines, became controversial for suspected links to autism.
  • Scientific reviews found no evidence that thimerosal causes autism or developmental disorders.
  • Thimerosal was removed from most childhood vaccines by 2001 as a precaution, but some flu vaccines still contain it.
  • The “Green Our Vaccines” campaign, led by advocacy groups and celebrities, called for eliminating vaccine preservatives.

Key Terms & Definitions

  • Vaccination — Administering a substance to stimulate immunity to a specific disease.
  • Anti-vaccination league — Organized groups opposing vaccination laws.
  • Conscientious objector clause — Legal exemption from vaccination due to personal beliefs.
  • DTP vaccine — Combined immunization for diphtheria, tetanus, and pertussis.
  • MMR vaccine — Combined immunization for measles, mumps, and rubella.
  • Thimerosal — Mercury-based compound used as a preservative in some vaccines.
  • Jacobson v. Massachusetts — 1905 Supreme Court case upholding states' rights to mandate vaccines.

Action Items / Next Steps

  • Review the timeline of anti-vaccination movements and key legal cases.
  • Prepare for discussion on the social and scientific impacts of vaccine controversies.