Lecture Notes: Tamsulosin (Flomax)

Introduction

• Presenter: Ryan from PMT Dossier
• Topic: Tamsulosin (Flomax)
• Drug Classification: Alpha 1 Antagonist

Mechanism of Action

• Alpha 1 Receptors:
  • Part of the sympathetic (fight-or-flight) nervous system
  • Target smooth muscle in the body
  • Effects include:
    • Vasoconstriction
    • Contraction of detrusor muscles in the bladder
    • Contraction of the prostate
• Antagonist Action:
  • Tamsulosin blocks/inhibits alpha 1 receptors
  • Effects of Tamsulosin:
    • Vasodilation
    • Relaxation of detrusor muscles
    • Relaxation of the prostate
  • Improves urinary flow

Clinical Uses

• Primary Use:
  • Treatment of symptoms of Benign Prostatic Hyperplasia (BPH)
    • Symptoms include nocturia, hesitancy, pain during urination, dribbling
• Off-Label Use:
  • Urinal stones

Limitations

• Not commonly used for hypertension treatment due to better options available.

Side Effects

• Common Side Effects:
  • Hypotension (dizziness, drowsiness, headache)
  • Orthostatic hypotension (common in elderly)
    • Sudden BP drop during position changes
• Monitoring and Management:
  • Monitor intake/output
  • Advise elderly to sit on the edge of the bed before standing to reduce syncope risk

Dosage and Administration

• Form: Tablet or capsule
• Frequency: Once daily
• Food: Can be taken without regard to meals

Conclusion

• For questions, consult comments or visit pn t CA for more information.