hello everybody we are live here on Tuesday night on the Dr bos show and we have a great great show for you tonight which had me curious several weeks ago when I started seeing a trend about methylene blue this blue dye that people are taking uh on purpose i think it started with a trend where Mr rfk was dripping it into his water and I have thought why would he be doing that and so as I look into possibilities I think it might have to do with his mitochondria it might have to do with um maybe some uh some defense system for helping against viruses maybe uh but I think you should lean in to say what could it be doing what are the mechanisms about the theory of how it works and then what are the risks that you could be doing that would either make you lean in or say um not for me all right stick around till the end we are going to start by sharing my numbers i did prick my finger right before we got started uh can you see that um glucose try that again uh my glucose is 71 ketones 2.7 a doctor boss ratio of 25 um I will um be uh watching for your questions tonight that we have my my trusted team uh watching for who the questions on the topics that we're going to be covering tonight uh we have done a little something different we've had some some not so fun messages come into the channel um when when I go to go through these lives and we want to find the people who are serious about helping their health and answer your questions here on the channel we specifically look for questions that are related to the topic trying to make sure that what I think I said on a live show might not have been the full thing and I have shot cleanup several times because you put in the the good question but you'll notice that if you're not a subscriber uh we took that away that you can leave a comment during the live again we're looking for the people who are here and they are leaning in to to learn about their metabolism all right uh as usual I'm going to start with my drink tonight but um I'm also going to put some blue dye in there let's see if I can do this with the microphone and the without spilling it on me so yeah one two three four five six seven eight nine 10 that's good i might be 11 so if you saw the thumbnail you'll know that I did this earlier and I um I will say that I definitely felt what this drug should be doing or what this um this um this um can I call it a drug this this dye is supposed to be doing and it is uh been a little bit of a rapid learning curve for me because the only thing I knew about methylene blue was as a resident when I was a young physician uh I can remember using it in an IV and I thought this is right out of a board question and nobody ever is going to need this question but we were practicing medicine in Salt Lake City so up an increased altitude and I'll show you the story when we get to that part of the slides uh but one of my good friends uh and uh 50 years in the military with way too many stories Colonel Al if you're watching tonight I did listen to you i did buy the book uh that we're going to talk about and give credit to uh Mark Sloan uh those that link to that book is in the show notes we covered a lot of what he talks about but we have done a few more things that um uh that he didn't cover so I'm going to start by having a drink of this and I will tell you that I've been taking this over the last three weeks and it does fall over April Fools so on April Fools if you've ever seen just Google Methylene Blue April Fool's jokes all right so some bubble water i put a little pucker up in there again my numbers are uh that glucose and ketones are after a pretty strong fast we did have an Easter brunch with the family but then we went on to uh what I typically do which is fast throughout the weekend or throughout Monday and into Tuesday so I am I am fasted by about 60ome hours umish yeah and I will maybe Yeah 60 hours is what I'll say all right let's get over to this this lecture because I think it's going to take me a little time to do this but in the show notes if you've ever tried this I want you to say yeah you know yes or no that you've tried it but if you did what what made you swallow something that can turn your tongue blue and make your pee blue i'm very curious because well Colonel Al is what made me do it but I uh as I read this book and I have looked into several of these articles I think many of you might do it for other reasons and we are going to talk about what are you doing what are you doing deep inside that um body of yours and is it a problem so this is a forewarning if you don't like science you should click off right now cuz I I used this as permission to talk about the things that I love to talk about and one of those is your mitochondria mitochondria are amazing and my team holds back because well a lot of you click off when I get too sciency so I'm going to try not to but let's just look at the headlines of what does this drug claim what does this I can't call it drug because I don't know what else to I mean to to call it a dye or something you order off of Amazon okay anyway uh what does this drug do um and here's the big like uh categories that I seem to lump them into uh and the first one is again where that story comes from in Salt Lake City emergency room uh and that is an antidote for chemical poisoning or overdose um uh the next one is antimmalarial drug it does have a great history lesson of that uh it is quite the virus warrior from tuberculosis to um um the I mean malaria isn't a virus but other viruses that are powerful in disrupting people the pain relief is what I probably saw the most comments on when I was looking on everything from Reddit to um you know the Twitter files um but also looking at why they claim it claims uh to be anti-aging and what is it doing to your brain because if you looked at that thumbnail it's not an accident that I did that the brain of animal studies and even those uh warriors uh soldiers that took this for malarial treatment if their bodies on auto autopsy were looked at their brains were blue if they were taking methylene blue their hearts were blue if they were if they were taking methylene blue so um we're going to talk about what that means all right let's get into the number one first thing that I like uh to to you know stamp in the the textbooks of if you ever take board's questions for internal medicine met hemoglobinia uh the antidote is methylene blue and that is the IV uh that um that I was that I used in this emergency room as a young physician and it was just so imprinted in my mind because it's the strangest thing to look at this blue dye going into the patient but um met hemoglobinia is a very dangerous problem um and it happens for a list of reasons uh let's go through the list of reasons of why um well let's just talk about hemoglobin before I go to met hemoglobinia met hemoglobinia is the pathology that's the problem but you should probably remember that you have hemoglobin in a whole bunch of your cells called red blood cells those hemoglobin strings have little uh or those globin strings have little cups of heem where iron can bind so these little iron things we did a um quite a few um lectures on this when I was teaching you about hemoglobin A1C and average blood sugars but that iron deep inside your body um is and in those cups of hee on those strings of globin attract oxygen and during that delivery of oxygen it's really important that the heem that the iron at the bottom of that um cup is has two charges i know this is really chemistry hang in there i um I'll get you there so again I'm reminding you we're talking about red blood cells here although this hemoglobin problem can happen throughout hemoglobinia can happen met hemoglobinia happens throughout the body specifically let's look at what's going on in the red blood cell and how that this becomes a deadly dangerous problem um so this is a red blood cell if we peel peel back the skin of that red blood cell and look inside you have millions of hemoglobin uh complexes and they all have oxygen at the bottom of them there i clicked through that slide a little quickly but uh you get the point all of those little places are carrying oxygen and when the oxygen gets to your tissue it offloads to supply the body with oxygen yeah there you go in um the problem with a if met hemoglobinia is that in this situation where iron is in the two plus state um you're I use oxygen here as a as one place that can become uh a free radical uh but that free radical happens only when you add that extra charge to the iron and this might seem really uh nerdy but it's important for you to see what's going on uh that met that this methylene blue might help change so when people have met hemoglobinia it goes from a a feritin or an iron 2 plus to an iron 3+ and it's in the presence of free radicals free radicals is this word that I think well that social media and influencers maybe like me have just bastardized this word free radical you know oxidative stress and what it's meaning isn't just this glib marketing thing there's actually something happening inside your mitochondria that create the these problems so let's see can I do this all right um I think I'm going to need to switch to this scene over here so you can see this full structure this is an iron molecule and this is what it would look like in your chemistry lab you may have remembered uh to do the um rings of uh electrons this center one ends up with two electrons and then the next one is 1 2 3 4 5 six one two three four five six seven is it seven i thought it was eight anyway whatever uh you get electrons in this run 27 been a while sorry guys uh but what happens is the removal of two of those turns this iron into a two positive charge and when you are in the presence of oxygen it's no problem that's not going to hurt anything uh that iron is able to um to be a recipient and and transfer of this little charge inside your body and this is all happening without you guys knowing and that's okay because who would want to know this right well um when you run out of parking spots or when the body gets overwhelmed with um this electrical charge with these these uh rogue electrons you know potassium or hydrogen ions is usually what it is um well you saw that now that that ring of iron is rusty it's now oxidized and those oxygen molecules um now get traded for free radicals and the iron charge is a is even higher now my nerds out there will love this you have now created the wrong environment the wrong this is this is what a free radical environment looks like uh an antioxidant would undo this without becoming um um a a free radical itself um but in the setting of our bodies there's only so much space for those free radicals and when when to to be absorbed and then the rest of them just run havoc they run problems in our bodies and when you look at um metabolic dysfunction it's the it's the acquisition that acqu you acquire too many of these little positively charged uh protons zipping around and causing problems so let's look at what are the causes of met hemoglobinia uh the first one is cyanide poisoning okay so in the world of cyanide poisoning um in the comments uh tell me have you ever heard of a king or a ruler um having a tincture that would prevent him from cyanide poisoning uh so maybe my family reads too many sci-fi books but this is always the theme i even think in Game of Thrones uh George RR Martin wrote in that you know the the um the person who was committed to serving the king who had all the tinctures he was giving him the antidote that if somebody tried to put cyanide in his body um he could live through it uh and this is it real in the history books that they would be the king would pee blue uh why was he peeing blue cuz he was taking methylene blue so what does cyanide do if you've ever seen in the movies they're very accurate that they put the pill in and within you know minutes the person is dead but if methylene blue had been present inside that cell and mitochondria it would offload the cyanide as fast as it would bind and if you had enough if you had the saturation of that body um you could prevent the cyanide poisoning uh now there's other myths out there that the kings would do is they would constantly take cyanide uh so that they would have a tolerance for it but I think it was very delicate to do that uh so the taste of this well I have pucker up in there so uh the sour is all I'm really tasting h not too bad yet okay let's go back to the slides uh so if you've heard of that in your um uh in your um if you've ever heard of having uh the antidote for the king I I would love to know in the chat if you've if if your family talks that weird too all right so here's what hap here's the the story from what we were looking at in uh in Salt Lake City is they had carbon monoxide poisoning again carbon monoxide was binding to that spot where that iron was and the oxygen couldn't get there and uh the antidote was uh methylene blue now it was also hyperbaric oxygen and several other things that we were doing but that was going to take time and the methylene blue we could get in the IV as quickly as possible to try and reverse this um other things are in high doses of acetaminophen that's Tylenol uh oops faldihide that's what chatgp that's what my typing did when I didn't check it's supposed to be firmaldahhide when you get fldahhide in a body it binds in this spot that I'm going to show you in a second fluoride also does that lidocaine these are um anesthesia if I if I numb up your finger to put some sutures in that lidocaine or benzicaine uh it's causing that it's causing metoglobin now me hemoglobinia is a toxic level of the that in your body um aluminum and copper just like those uh like the ferotin is two plus and can um can really uh make it difficult for the oxygen to bind all right this is the last super nerdy one my team said you can only do this really quickly so this little uh uh lipid layer here is um the inner lining of your mitochondria and there are these complexes here is um a protein complex this is complex one uh and this is complex three and this is complex 4 and um cyanide completely blocks uh complex 4 you cannot get these hydrogen ions to go from the inside of the mitochondrial the inner membrane to the outer membrane because cyanide blocks it 100% there is no getting anything through here but methylene blue prevents that um of note metformin is blocked by u metformin blocks the transfer of hydrogen ions for complex one um and we aren't going to cover that today but hang in there uh so I've shown you this slide many times that is a super nerd slide and for those of you that liked it I would love to see the praise in the comments because many of you don't like this uh but here's a better way to just lift the rest uh even me when I'm thinking about this I will look at yeah mitochondria are not all built the same this is a muscle cell and it's not exactly a muscle cell but you can see that it's muscle cell uh it looks like a muscle meaning I made it a cartoon but in there there are two types of mitochondria in this setting some of them are really healthy and they are able to quickly fat adapt burn fat as as quick as you'd ask them to um that would be like this guy here um but you also see that this red one here is um it's the red is to represent that it doesn't burn fuel as efficiently so at any one time inside our cells mitochondria are going to be at different levels of health and I've said this many times uh that there's a difference in the way healthy mitochondria look and unhealthy mitochondria look this one has really beautiful folds along that mitochondria there uh I mean that's gorgeous and that's that place where I had zoomed into with those complex one three and uh four um it's perfect it's beautiful um and that's where life happens i did a a a lecture to a several um people of faith and I titled it the Holy Spirit is in the wall of the mitochondria because as soon as that um mitochondrial wall doesn't function you die cyanide is here is an unhealthy one you'll see that it's supposed to look deflated this one is supposed to look nice and very taut very full it's perfect but this has it's kind of deflated it's not really strong and it's got some uh it's got some dysfunction in there there's some holes in there we'll get there in a second so this mitochondria if I said "Let's put some glucose in that cell and watch how it turns um those glucose that glucose into uh energy." Oh there we go all right so glucose comes in glucose goes to pyuvate some of that um energy is uh um some of those electrons are transferred through there and energy is made by lactic acid and suinic acid but the majority of that energy is coming from the part where it went up along here along this and down here and that is your electron chain transport this is why it seems like a panacea if something trades electrons it's helping the mitochondria to do a better job of efficiently moving those electrons along and I've seen several influencers try to talk through um this electron chain transport saying "But you can only see the effect of methylene blue if you have anything that might affect that if something is blocking that transfer of protons." And I'm like "Yeah no need to worry you have plenty if you've been around the sun a few times you have plenty of examples of how this is working now this is one of those mitochondria that are blue and is more fat adapted this is what I try to do every week by fasting and teaching the ketogenic diet being in a state of ketosis notice there's a lot more electrons coming out of that uh mitochondria it's in the same cell it's in the same place but it is very efficient at turning that uh fuel of fat into you know here we have ATP you can call it energy whatever but the way it did that is the transfer of electrons uh of uh those hydrogen molecules in and outside that mitochondri or in and outside that membrane and that's where methylene blue is effective uh or that's where it gets to at least um the dysfunctional mitochondria starts out looking like this and when we really zone in you can see there are holes in that in this membrane so again here is the membrane where the the complex is pushing the hydrogen ions out and then uh the next one pushes them in and the next one pushes them out and it's this transfer of energy that keeps us alive okay so what happens when it goes wrong well if you start with glucose and you shove it through one of these dysfunctional mitochondria you're going to see yeah yeah yeah glucose to go into the cetal coa go to the KB cycle okay what happens next oh my goodness there are electrons coming outside it it doesn't make it all the way to to this part of the of the chain the electron chain transport is broken okay this is the foundation to metabolic disease metabolic disease is when your body ages when your body uh um lets these little rogue uh electrons out to play inside your cells and they hurt your DNA well now the gene got nicked and now it's a you know it's genetic mutation well how'd that happen oh because you were um inflamed um Oh you've got that that joint that keeps hurting and it's been hurting for several months and you know when the doctor does a MRI and says "Well what's wrong with the joint?" Ah there's all this this bogginess or this swelling around it uh what's going on oh inside uh these mitochondria you're pulling um you're pulling cyto you're pulling fluid and it hurts it doesn't it doesn't feel good um well how do you get that to go away well you don't leak electrons outside the side of your mitochondria for starters so as I look at um methylene blue and say well what did this drug do it took that iron with the three uh um the three uh empty spots is that positive charges and it returned it back to a much more stable molecule of um iron you know feritin or ferrris 2 plus um on the periodic table this is all happening inside the mitochondria and we took it from a free radical which is very dangerous bounces around that cell causes damage bounces around our brain bounces around our heart uh and um well if if you've got a a severe problem of the oxygen can't bind and I put methylene blue in yep I can know that happens but most people that's not what they're struggling with they're not walking around with uh carbon monoxide poisoning or a tincture of cyanide in them they are walking around with years of inflammatory problems deep inside the cells and we talk about yeah if you want to um slow down aging you do need to get your mitochondria in shape they need to look this beautiful uh and that uh beauty is right along that membrane here where you're pushing electrons out and you're pushing them in and then you're pushing them out and that's how our energy is made an intact mitochondria um will shuffle those protons along that uh internal membrane and that's where people come into my clinic and say "Oh how can the h how can I have all these problems all of a sudden?" Like you don't have all these problems all of a sudden you've been brewing these problems for 30 years well how did I do that well the way you've been fueling those tiny little mitochondria they're they're running hot they don't h there's nothing that's been running cool well how do I how do I run my mitochondria cool well you got to change the fuel up when the fuel is only in the glucose lane man is it tough on those cells and your cells are on your side they don't want you to die anymore than I want you to die but the the byproduct of dealing with only that state that one fuel turns into chronic increased protons in the wrong spot okay which is chronic inflammation which is reactive oxygen species which is free radicals all these terms that people use but I often think that the punchline is missed when you say well what could possibly um be a way to undo the damage I've done in my body and I'm going to start by saying if you're walking to the methylene blue link and saying "Oh I'm going to put this in my body and it's going to make all this go away." Is not that good stay tuned there's some problems ahead i I will get to them so yeah for any uh physician that's out there or somebody that works in a clinic my stir stick i wonder if anybody notices what that is that's what happens when you're doing a live and you're like I just need a stir stick and I'm out of tongue depressors uh okay next slide let's go to here we're getting to the good stuff all right so the antidote for chemical poisoning or overdose that was the cyanide uh lecture that I wanted to make sure you saw yeah this is complex 4 and that's the one that's blocked to cyanide it's also um a major problem uh when carbon monoxide is u actually is binding to the um place on that hemoglobin molecule and um we now need to transfer electrons and to get it off there so that the oxygen can bind again um so looking at um those nerdy nerdy things they do really matter let's go through the other things that I said earlier in there so the most um you know if you're ever taking internal medicine boards here's a great answer methylene Blue is a real treatment and what is you know what's shocking to me is whenever somebody asks me about a you know an antioxidant I'm always like "Oh good grief." Um it doesn't do that much um and the reason why is the amount of particles of molecules of whatever you think this antioxidant is doing that it takes to get it inside the cell and into the mitochondria well heck um they're they're not funded by you know major organization or major national institute of health trials um they are you know they just say "Hey I'm an antioxidant." I mean which means might be true that they can grab that um that energy and put out that one free radical but you need mi billions of them in people with chronic disease to prevent you know the aging of the brain you need millions of them and when you swallow that acai berry and you say "Well I wonder how much of it's getting into your mitochondria." I would say not diddly you got to swallow it it's got to get past your gut and then your gut's going to port it over to the liver in some cases and then your liver is going to say toxin not toxin so it's going to sweep out a few more and then it's got to get in your circulation and then it's got to get through a cell lining and then it's got to get into the mitochondria and like good grief that's a long journey for a one one uh it doesn't have to get into the mitochondria but it needs to at least get really close to that mitochondria to help grab that electron that um that um hydrogen ion so how do we know that methylene blue does that well uh this again been around for a long time i think of um one of my favorite uh musicals is Fiddler on the Roof and maybe it's cuz I'm from the Midwest and there just wasn't a lot of Jewish tradition for me to experience and I I felt um these two parents trying to raise kids and kids doing things that that you the parents didn't want to and the struggle of why do we do these things we do tradition uh and so you look at some of the Jewish tradition and when they wear that shawl around their waist and then the tassels at the bottom of that shawl uh well they're they're slightly tinted blue and it's part of some or Jewish ritual if please correct me anybody who has a much better understanding of this but uh where that methylene blue been around a long time known for being um uh cleansing uh now maybe that's a spiritual ritual in their situation but it is actually a uh antidote for um fighting viruses for um for cleansing uh something but you're going to be blue you're going to have a blue tongue i don't have that that blue tongue today you know the next place in history that you got to see a bunch of um the um uh credit given to methylene blue was during uh like the discovery and discussions of tuberculosis and malaria um one of the ways the soldiers in the military were checked that they were taking it was the doctor would look at their pee because it was blue if they were being compliant with the the tincture then they're they would pee blue uh and like I said earlier at autopsy we would see a couple of organs with really high mitochondria the brain and the heart turn blue uh all right next thing was a virus warrior looking at that cytoine response being uh toxic and actually sometimes good for the virus bad for the human and we just see a uh not only a antiseptic uh component to methylene blue um but if we wanted to see any of this under the microscope which is where the malaria team really became aware of it is they stained the tissue uh with methylene blue uh in hopes to be able to see the little critter the malaria um uh organism on the slide uh same with tuberculosis very difficult to see but when you use methylene blue you could see it more clearly uh the next is that pain relief that I talked about when you have the um chronic inflammatory problems uh of um uh of a joint that's not going uh that's going sideways i'm I don't know when I look at the number of people say why did you take methylene blue and I've been watching some of these um to say did you take it for joint pain did you take it because you wanted to see if a pain could be reversed and um if you took one dose and the pain went away for sure that was placebo it doesn't work that quickly um as I took a whole like 15 um droplets of this to take that thumbnail where my tongue was blue for like the next hour and a half I uh I felt high i felt like uh not only do I have high ketones but I now just added methylene blue which you know maybe it enhanced the way that uh those electrons are those protons are being transferred over that mitochondrial membrane i don't know but my team was like we were trying to record a video that's going to come out later and I was like my speech was super fast i had to really think about slowing down um but I've been playing with this for about three weeks uh and when I first started with it I I mean I noticed the blue pee right away right um I even was really careful to not spill it on anything and I said to my team "Good Lord just don't let me spill this while I'm on the live." I'm going to take this out i'm afraid to put it down because wherever it touches it's going to be blue but as you look at the taste of it it doesn't have much of a taste um it just turns things blue so um it probably took about three weeks or no it probably took about the better part of five days for me to know that um as a physician one of the um first one of the places early in my career was do I have the answer for the problem okay and I know that y'all hate on oh doctors are just connecting these two but at the beginning uh especially I was planning on going into the ICU so I wasn't planning on doing primary care uh but now I was in primary care and I was just trying to match up this problem goes to this you know what these symptoms go to these problems without ordering a bunch of tests and when you look at the first joint to fail in most people it is the base of the thumb the base of the thumb and u my left hand base of the thumb um uh well it's begun to hurt over the last couple of years um but I when I remember back in the first few years of practice whenever the base of the thumb would hurt I would instantly be able to say "It's osteoarthritis ibuprofen anti-inflammatories use some ice." So I mean I would quickly file it in the here you're aging okay let's get to the problems that are going to kill you uh yep that's part of aging and I really hardly gave it more of a thought than that and then there's payback so as I I'm 54 now but a couple years ago I could start to feel that that the base of my thumb uh would hurt and in fact I on Sunday on Easter Sunday my three boys and I went golfing four of us playing baseball that's how good we are at golf it was great but I by the end of the golf round my I couldn't grip the the the um the golf club um as tightly as I could at the beginning why because the base of the thumb was hurting when I look at the the change that I saw within five days of starting this I noticed that oh that thumb doesn't hurt as much and I didn't test it with a golf round but um it it does help me to say oh that's probably what um folks are experiencing all right so hang in there there's a couple more things we're going to cover then we're going to get get to this does serotonin does methylene blue cause serotonin syndrome okay we're going to come back to that in just a second that is what if you look at if you Google what's the enemy of um the uh methylene blue what's the danger what's the problem we're going to talk about is it real I I bet you'll be surprised by my answer okay so I do want to show off something that I am excited for as the mother of three and a daughter and uh friends with lots and lots of mothers there are several of you that are um may or may not be aware that in four weeks is Mother's Day and we are doing an excellent um uh sale on my favorite thing to give moms which is um our um our glow serum so it is usually $150 uh it is something that I use um frequently and I I took a risk putting a product that doesn't have anything to do with the ketogenic state on the market but it's because I think this should be in every person what this is the only thing I use on my skin it are it is the oils that do penetrate those top layers of skin and although I can't make my skin glow like this if my mitochondria weren't healthy it sure bridges um when um maybe when I'm not perfect but also I'm 54 years old i want my skin to look great and I don't want to spend a thousand you know $100 for this thimble-sized version of that this is designed to use frequently and know that the first time you put it on skin that hasn't seen it it will feel oily for the first 20 minutes but then it does penetrate through that skin layer and I some of my favorite reviews of any product I've ever made have been uh this product so we are putting it on sale between now and Mother's Day if uh if you are looking for the best gift um I would I would love the support for the channel but I'd also um love to hear the reviews of that okay uh I also had something on Dr bose's favorites I was supposed to tell you oh I know what it was um so many of you know that um Oh first of all there's methylene blue if you want to do that it's just the link to Amazon but it shows you which methylene blue I'm using here um I have a couple of major um uh videos coming out about um continuous glucose monitors so if you don't have one and you're looking for the prescription one the good one oh I thought it was sitting here the G7 and you want a prescription for that my team and I in meaningful medicine make this a very userfriendly way to get the one you can calibrate which is the one I trust uh but next I want to show you something here called Carb Sober Cruising uh this is by a friend of mine who is kind of new in my uh universe um and I am Dr lisa i was like "Oh what's her first name?" Uh Dr lisa is uh leading a carb uh sober cruise um but the interesting thing is it is right after uh if you've been to Hack Your Health uh it is now called or um it's called Hack Your Health Now it used to be called um KetoCon and Hack Your Health is um in Tampa in November and that's on like a Saturday and a Sunday and it is again one of my favorite conferences it's it's tons of fun um uh I've become good friends with the gal who runs it and I just think she does an excellent job um but what happens in Tampa at the end of that is this cruise where there is a lot of hangout sessions with the speakers um and it takes off right out of Tampa so two days of a really uh great conference learning about how you can hack your health uh and then head off on a carb sober cruise and again this is a smaller organization so uh it will fill up it's not a huge cruise ship and it's not designed to be super um didactic it's meant to be um you know lots of Q&As with their speakers uh so if I don't know if I get to be one yet and I mean that because of my schedule not hers um but if I do um a Q&A with me on some of the sailing days and then it's just time spent what does it look like to eat no carbs for a week now there's ways you can break that it's not like they're the carb police but I just think it's a powerful teaching uh uh when you watch somebody model the behavior you're trying to become better at so if you're looking for that the season's right it's in Tampa November uh and it's right after Hack Your Health so two ladies I am very excited to support all right let's get back to does Methylene Blue cause serotonin syndrome this is probably the number one thing I saw in um you know several of the um influencers out there saying "Oh you know is this a you know this is the true um problem with this?" Let's talk about serotonin syndrome and why methylene blue might be at all affecting that so methylene blue um uh first of all serotonin syndrome is when serotonin goes rather high relative to what you experience what you're used to um and causes um think of it as them I think of it as like the motor is really high in their brain uh so their their temperature can go high rate can go high I mean it can be deadly if we can't um back them off the cliff but methylene blue um is a monoamine oxidase inhibitor Monoamine oxidases are enzymes and they break down uh neurotransmitters in your brain um the we have monomine oxidase A and monomine oxidase B so it kind of adds a little chain on each of these uh the monomine oxidase A enzyme breaks down serotonin breaks down norepinephrine the monomine oxidase B predominantly breaks down dopamine so there are two pathways and these are really important when you are manipulating your serotonin that um when we look at monomine oxidase enzymes um that is part of our it's normal that's what we have to have you can't have that in your body at all all you can't have serotonin and norepinephrine in the body and not be able to break them down but when we look at the types of monomine oxidase that I is really important the monomine oxidase inhibitors we look for those that are reversible and then those that are irreversible reversible means okay it binds to that enzyme and stops it from breaking down that neurotransmitter and then it you know something shifts in the chemistry and it breaks away it is a reversible bind of this enzyme um there are prescriptions that I call these old school prescriptions because monomine oxidase inhibitors um they're nothing as easy to you as to prescribe as Prozac or Paxel or Zolaf or Lexapro um so they're old they are irreversible now once you bind to that monomed oxidase inhibitor that enzyme will not break down serotonin anymore and the serotonin will start to rise now in part that's how they're treating the depression they're raising the serotonin in the brain they're raising the norepinephrine in the brain and I know with all the recent is that how Prozac works but who cares that's not what I'm talking about i'm saying raising of serotonin inside the human brain changes how you function how you think and in healthy people like I took that shot to take the thumbnail and my tongue turned blue um and I'm like energized like okay I wouldn't call it mania but my speech was fast and I was like having a tough time sitting still like I got to go for a walk I got to walk off some of this energy uh some of the old school um monoamine oxidase inhibitors the the prescriptions are uh phenel phenelzine phenylene phenoline and sleilene both of those so I do not prescribe those I think I've written them once or twice as refills early in my career and then like that's a lot um this one I've never even heard of i googled it and indeed it is a reversible uh molecule uh where it doesn't stick so u the key thing that I I always think is important is if you do inhibit an an enzyme in a irreversible way so you took out the crop of enzymes that are breaking down serotonin um now to re restore those enzymes it is a long road it is a long road weeks before those enzymes are back in the brain functioning uh very tightly so I a an irreversible monomine oxidase inhibitor would be at high risk for serotonin syndrome so what is methylene blue well it's a monomine oxidase inhibitor uh it is reversible and uh it c it can be knocked out by other factors so as soon as the pH changes or um anything else comes along to touch that enzyme or even just the temperature rises inside a body you can see that um that uh connectivity between the enzyme and methylene blue undo uh so that makes it safer i think it is important to recognize that methylene blue is uh strong in the monomine uh a monomine oxidase a which is your serotonin team your norepinephrine team and not so much in the dopamine I mean it's not like it doesn't affect dopamine enzyme inhibition but it's not as high so punch line reversible monomine oxidation inhibitors are regarded as safer that it's not as profound u all right so before we go into this And uh the last thing we're going to talk about is All right so you get into um uh this world of methylene blue uh I'm I'm trying to get this done by the time I finish this video a little bit blue okay with um um the places that I've looked at this uh so first of all I totally put it in uh h had it put in the Starbucks of the people I work with and they peed blue on April Fools yes and I wasn't worried about hurting them it is a reversible monomine oxidase inhibitor and the amount that I put in their coffee to turn them blue was like 10 drops it was very little um but as I started taking this over the next couple of weeks and I had my husband take it and I had one of my kids take it saying "I just want to see how you feel." Uh and then I was reading about this like okay I get what it's doing when there's a strong amount of damage done to the body uh this is where this has been used uh I've seen several protocols uh where they're looking at the damage done by radiation uh for for a treatment of cancer and that the amount of free radicals is just a lot for that person to handle they're not healthy enough to really keep that energy flowing through their mitochondria and in fact some of the mitochondria are being sacrificed because of the shift and the just incredible number of free radicals in their system and I've seen protocols where they're using methylene blue as a way to to um to temper uh that those hydrogen ions and really shuffle them along that internal membrane of the mitochondria uh most common thing I see online is the um reversal of an inflammator a joint that's been chronically inflamed and it's not on the first day it takes three or four days before they start to feel it by the end of the first week you can often feel it um and I have some other places where I think uh it is very interesting but I'm going to leave it off of the here and see if it's in the questions and we'll we'll we'll answer that i will um do one last thing which is show you the um the dosing loom slides here we go uh let's see if I can make my head a lot smaller here uh so if you look at um the body weight um over here of kilograms and you know 110 let's see here 110 120s so um the highest recommended do uh effective dose would be 2 milligs per kilogram so that's this uh column right here uh we think the minimum effective dose is going to be here you can go I mean the people who have problems are like 10 times the dose of that um and it can overwhelm those uh enzymes breaking down serotonin um again it is reversible there's lots of things that can be done to to offset that but looking at the the weight that you're at here in kilograms versus pounds uh if you look at a half a milligram for per kilogram that's about um let's just uh let's take 120 lbs uh 55 drops a day so right before I got on here you saw me put 10ish drops into my uh that liquid and then for the thumbnail earlier today I think I had about 10 I had a dropper full like 10 drops of methyline blue so that's 20 drops of methylene blue so if my weight's about this range I'm still not at a half a milligram per kilogram per day um to get all the way up to 220 I don't know that I can do that don't know that I can do that uh all right so let's uh go back to our chat here really quick let me shuffle things around i do want to make sure I tell you again uh I skipped a lot of stuff there's some really interesting stories uh as I look at um Mark's biography he's got some other books that I have on my uh list that I'll probably read but he is a independent health researcher so uh take a look uh give him a a shout out if um if you have any connections to him to say thank you and um the link in the show notes just allows um the you to get to his Amazon uh place where he's selling that book okay let's get over to your questions oopsie let's try that again questions here all right uh now I'm ready okay sam writes in and says "I have been reading about methylene blue being used uh for some cases for inflammation of pain do you think that there's any potential role in managing joint issues yeah I would tell you Sam this is the number one place that I I've been impressed i mean I don't like to put drugs in me either um but I don't like that thumb pain i do want to golf with my kids a little bit more uh I'm not interested in stem cell uh injections uh at least not at this stage but I I do I do see that it bothers me um when I look at the number of the volume of people that that's why they first did this um I find it's quite um that's the that's the majority is they're doing it for the pain relief and with pretty good antecdotal responses i mean there's some really great studies out there that are looking further into that mitochondrial dysfunction um but nobody's really looking at it for joint issues so it's really been an anecdotal response that I've learned from um how long do you take it once I stop will the results stop you know that that's been um that's a great question first of all uh looking at the length of time for it to help um is the another place what I was I didn't mention earlier um is have you ever seen people use it in their fish tanks again that antiviral that antiseptic that doesn't kill the fish but does keep that fish tank clean i think the virus that I or the the infection is called ick that's gets inside a fish tank and methylene blue is the antidote um and so you look at people that have been exposed to this for a while and they'll say things like "Oh I think my joint pain is better." And they're just working with it now their skin is blue if they're working with it but just it's very strange to hear that again and again and again even with a topical application of it um how long do you take it um I would I would at least give yourself four weeks of this um I take it in the morning uh so I'm I did well then Easter came and um I didn't do so well over the weekend but I'm back to trying to be rhythmical about it again and I have a commitment of saying I want four consecutive weeks of trying to get to at least a half a milligram uh per kilogram per day so that's going to be a dropper two droppers in the morning how I like to do it is kind of what you saw here is a small amount of liquid uh cuz it does not have an aftertaste but it does have a taste so if I can get it down as quickly as possible it's kind of a bitter taste i usually chase it with some uh bubble water some sparkling water uh and then I'm off to do my day and have my coffee and do other things so I do it in the morning when I've taken it at night I I feel like it makes me have to go to the bathroom and I don't mean like the volume of urine it's like I feel the need to urinate um and so I I try not to do it right before bed uh I learned that the hard way kind of all right next question um is uh how does this affect people with alphathalmia so again alphaththalosmia is a uh a hemoglobinopathy um where the hemoglobin isn't it's got a defect in it um and if I remember alpha hemoglobinopathy they they have a increased binding of the oxygen it won't release the oxygen as quickly or maybe it was an increased binding of the carbon monoxide boy or carbon dioxide or not carbon dioxide um it's an increased binding of the oxygen i'd have to look again uh I don't know the answer to that i like questions that make me look things up though so I'll look it up what percentage is safe to use is uh genten violet the same i don't think Jensen violet is the same uh if somebody in the chat uh knows that answer uh I'm watching the answers in the chat in another screen here so um I don't think it's the same um Julie writes in "Will methylene blue mess up my pea sticks that I'm using for Dr ana Beca?" I did get a message from Anaka Becca's team uh saying "Hey these uh these uh folks of yours that you sent our way um they are all worried about being more than 20 carbs per day they're worried that their insulin resistance is not going to handle 20 more than 20 carbs per day and and they actually want to stay carnivore." And I sent them back a video saying they're right they are very insulin resistant don't push them higher than they should um but you if you look at what Anna Quebeca does and again this is the folk the gal who is u magic menopause really works with female hormones has a much higher level of um understanding and passion to really answer some of the uh female hormone questions i am superfic I mean I I do what I do but I don't have the space to do it for the volume of people that Anna's really Dr kbeca is working on um and what she looks at is taking care of patients that are um that are going through menopause and um she has a lot of the same uh like core beliefs in that you must change the pH of the system in order for those fatbased hormones to circulate the reduction of insulin will decrease um that um will improve that metabolism will increase the ketones decrease that blood glucose and in the urine the pH will shift and so the way she measures compliance I make prick your finger and put your numbers up there that's a much more strict and and again many people are kind of repelled by that level of commitment but I don't back away from that i really think there's um um for the patients that come to see me they're they're sick they've been insulin resistant for years their mitochondria are exactly like that picture in the slides they are broken and those uh uh protons escape out and do naughty things um and if you want to reverse that you have to stay in a state of repair uh urine is you know on the spectrum on that pendulum of saying okay we can measure that they're in the right place uh I just take it way further um because my patients are much sicker than folks going through menopause and trying to get their hormones reversed so the question is um well is it going to screw up the pea sticks i'm pretty sure her pea stick I mean it will turn them blue but I'm sure pretty sure her pea sticks are measuring the pH of the urine so I don't I don't think it it will shift that um might want to ask chat GBT though because I've never thought about that okay let's go to the next question aloha 22 you are just a regular i love seeing you ask the questions and I'm glad your question made the list uh so I am a regular red powder which is red blood cell uh greater need for that than whole blood um donor so she she's a re he or she is a regular red powder donor via the Red Cross would ingesting methylene blue cause them to reject my donation so here's what I know about whole blood um so methylene blue although it does um reduce the ferrris from the 3+ to the 2+ uh it it does not bind in the place that the oxygen does it just allows the iron to put the oxygen there um you know one of the places we can see binding for um uh methylene blue again at autopsy we see at brain and and in the heart uh there are other places but those two are super concentrated why because they have a very high mitochondrial load if you were like look at the mass of the heart relative to like muscle mass and mitochondrial mass it is super one of the highest organs the highest density organs for mitochondria is your heart and that's how we stay alive right um methylene blue has an affinity to that mitochondrial inner lining so um it would be a rejection for a heart transplant i don't even know that it would be a rejection for a heart transplant but um your red blood cells don't have a place for that to anchor it does affect the iron that's in that and allows that oxygen to rebind in carbon monoxide poisoning but I don't think there's a binding of it so I don't know that's a good question not a fun All these questions are going to send me studying for the next week all right brian writes in next and says "Is it safe with other meds is there anything we can't take with them?" Well I'll tell you because this is a YouTube channel and I am not your doctor uh that if I had to look at the places I would still put restrictions or put caution as I would talk to your doctor if you're taking an SSRI or an SNRI um those are drugs that um inhibit the re-uptake or the vacuum uh of recycling serotonin in your brain and or norepinephrine in your brain prozac Paxels Allex Alexapro uh uh Satalopramg um Effexer i'm forgetting a few several actually but those are the kinds of anti-depressant medications that I would definitely be talking with your doctor about that but have I mean when I see some of the other influencers out there saying you're you you can't take it with that I am very cautious to say this is not a an irreversible binder of a monominoidase inhibition it is reversible and then this is over-the-counter been around for a couple thousand years prozac been around since what mid 80s uh and maybe it's 90s i think it's the 80s um if people were taking methylene blue and Prozac we there would have been a much bigger signal if the serotonin syndrome was actually happening i did some searches trying to find some case reports and you'd have to drink the whole stinking bottle uh to have an um I mean you just have to do a lot and I got a pretty strong stomach i'm like that's enough i don't want to that's enough it's got a very bitter taste again skip the tongue get it in your stomach and chase it with some bubble water that's what I do uh so I I think anytime you take a medication or something that does actually get into the mitochondria you should talk with your doctor and this is a YouTube channel telling you all the things I wouldn't want to get in trouble for uh all right grace says "Is methylene blue better than blueberries for inflammation?" Hell yes can I swear hell yes this is a perfect example of where acai berry used to drive me nuts there was a multi-level marketing company in Utah that would sell all products that are byproducts of acai berry and they would tout that they reversed cancer they you pour it on your body it was going to improve you and I'm like it is not getting to the mitochondria you can't even start this conversation till you prove that that that little antioxidant gets to the mitochondria and what I've noticed with blueberries is yes there are antioxidants in blueberries but my people that watch this channel they like food too much and they love the buzz of food they they eat the whole dang box of blueberries and and they do it with with hedonistic joy like it's not just a a satisfy this anti-inflammatory this is their I can't have fruit except I know this is good and then they eat more and they eat more and then their sugars are high and their ketones are down and their insulin is off the charts and they're creating those mitochondria with those little holes in them instead of reversing them so Grace thanks for that and my team is just smiling right now because they would know that I would eat that one up last question by Dale would it help a skin infection would I put it on the skin you know I wish Colonel Al was on this uh show with me Dale because he also had me reading about another thing that I hope to do a live on or at least a discussion on oh I bet you it's here ha it is here um so before you go by methylene blue and turn yourself into a smurf um this was the other thing he told me to read i've started don't ask me questions about it but um the first 10 pages make me say um I don't know about skin infection it would sting like hell I bet um but there are other things that can get you um um when when the fish tank people use it in the fish tank and their skin turns blue because the water is got blue dye in it but the ick inside the fish tank did go away so there is this aniseptic process to it um you know the other major finding was looking under a microscope we're dying tissue to find malaria to find that tuberculosis which is super tiny difficult to find you know hides in like very camouflaged place for us to see it under the microscope but the methylene blue helped us see it and those same scientists said oh my they're dying so there's this um reversal of the malaria um sur I mean the survival of malaria was uh reversed with that as well all right troops i am uh super thankful for everybody that's tuned in to this point i am also going to be watching to see um uh how well uh the mother's day gifts go out i really appreciate the support for the channel and I will use your questions to keep studying for future lives so please keep putting the questions in the chat even uh when I'm not here even on replay because it gives me good ideas for what you want to hear from going forward uh I'll see you guys uh next week uh sign