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Brain-Heart Interaction During Exercise

Aug 11, 2025

Overview

This lecture explains how the brain and heart interact to control heart rate through neural, hormonal, and intrinsic mechanisms during exercise and recovery.

Brain-Heart Connection

  • The medulla oblongata, located at the base of the brain, contains the cardiac control center.
  • The medulla connects to the heart’s sinoatrial (SA) node (pacemaker) via neural pathways.
  • Two nervous pathways influence heart rate: sympathetic (increases rate) and parasympathetic (decreases rate).
  • Sympathetic control uses the accelerator nerve to stimulate the SA node and speed up heart rate.
  • Parasympathetic control uses the vagus nerve to slow down heart rate.

Neural Control Mechanisms

  • Chemoreceptors in the blood and brain detect changes in blood acidity (pH).
  • During exercise, a decrease in pH (increase in acidity) triggers sympathetic stimulation to increase heart rate.
  • During recovery, an increase in pH (decrease in acidity) triggers parasympathetic stimulation to decrease heart rate.
  • Baroreceptors in the brain monitor blood pressure changes.
  • Increased blood pressure stimulates the sympathetic system; decreased pressure triggers parasympathetic response.
  • Proprioceptors (mechanoreceptors) in muscles and tendons detect movement and tension, signaling the medulla to increase heart rate during exercise.

Hormonal Control

  • Adrenaline (epinephrine) is released in anticipation of or during exercise.
  • Adrenaline acts directly on the SA node to increase heart rate, independent of the brain.

Intrinsic Control

  • The heart senses internal changes such as temperature and contractility (changes in venous return).
  • Increased heart temperature or greater venous return causes the heart to contract more frequently.

Key Terms & Definitions

  • Medulla Oblongata — brain region that regulates cardiovascular function.
  • Sinoatrial (SA) Node — the heart's pacemaker, initiates heartbeat.
  • Sympathetic Nervous System — increases heart rate via the accelerator nerve.
  • Parasympathetic Nervous System — decreases heart rate via the vagus nerve.
  • Chemoreceptors — sensors for blood acidity (pH).
  • Baroreceptors — sensors for blood pressure.
  • Proprioceptors — sensors in muscles/tendons for movement/tension.
  • Adrenaline — hormone that increases heart rate.
  • Contractility — heart's ability to contract more forcefully in response to greater filling (venous return).

Action Items / Next Steps

  • Learn and differentiate the roles of chemoreceptors, baroreceptors, and proprioceptors.
  • Remember which changes (increase/decrease) each receptor type detects during exercise and recovery.
  • Review the pathways and effects of sympathetic and parasympathetic stimulation on heart rate.