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Notes on General Organic Chemistry

Jan 1, 2025

General Organic Chemistry (GOC) - Lecture Notes

Introduction

  • General Organic Chemistry (GOC) is considered the gateway to Organic Chemistry.
  • It is the ABCD of Organic Chemistry.
  • It forms the basis for chapters like hydrocarbons in 11th grade, alkyl halides, alcohols, phenols, aldehydes, ketones in 12th grade, etc.
  • Solving difficult questions is challenging without GOC.

Importance of GOC

  • GOC includes general aspects of organic reactions.
  • Which reaction will proceed faster? What intermediates will form?
  • Which compounds will show acidic or basic nature?
  • It's a very important topic.

Effects

Electronic Effects

  • There are four major electronic effects:
    • Inductive Effect
    • Electromeric Effect
    • Hyperconjugation
    • Resonance Effect
  • The inductive effect is temporary while the others are permanent.

Inductive Effect

  • It is the displacement of sigma electrons towards a more electronegative atom.
  • Partial charge development occurs.
  • When electrons are pulled, it forms an electron-withdrawing group (called the minus I effect), and when electrons are provided, it forms an electron-donating group (called the plus I effect).
  • This effect decreases with distance.

Uses of Inductive Effect

  • Helps to determine the stability, acidic and basic nature of reactions.
  • Explained with excellent examples like the stability order between FCH2COO- and CLCH2COO-.

Reactions and Mechanisms

  • Understanding the intermediates formed during reactions and their mechanisms is essential.

Acidic and Basic Nature

  • How to determine acidic nature?
  • More minus I effect, more acidic nature.
  • More plus I effect, lesser acidic nature.

Important Orders

  • Orders of Minus I and Plus I groups are explained.
  • Some major orders:
    • Minus I: NF3+, NO2, CN
    • Plus I: Tertiary Alkyl, Secondary Alkyl

Assignment

  • Homework: Determine the basic nature of CH3(NH2) and other compounds.

Conclusion

  • Detailed explanation of the inductive effect and other effects.
  • The next lecture will be even more interesting.