this is going to be an entertaining one even simply because I've been corrected many times on how to pronounce ninas at one point I thought I'd gotten it right but then I was corrected again well then how many times will I butcher it this time I'm like the Freddy Krueger of pronunciation at any rate I analyzed eight studies on the impact ninas supplementation has on our heart health including the effects on blood pressure blood lipoprotein levels clotting effects post heart disease recovery and finally reversing atherosclerosis and that's why you're here that or your dog clicked on this video by accident as it was adjusting its sleeping position on you and you ended up Spellbound by my dashing good looks now now I'm taking you rascal by science my stable mistress actually in my initial investigation I did analyze eight studies but someone sent me another that I had overlooked so I'll include this ninth in this video so what's the deal with nyas can it reverse the plaque that's built up in your cardiovascular system well that answer depends on one thing which of the two arguments I'm going to make based on the data you believe I'll get into that but it might be useful to Des describe the many ways that ninas has been described to create benefit for your cardiovascular system across these studies what's funny is that in molecular biology a kyes like that attributed to naoy is an enzyme that adds a tag to proteins in and around your cells called a phosphate so you would expect that ninas to be a kinas enzyme and you'd be dead wrong or at the very least wrong although you don't need to die ninas is an enzyme but it's a protease meaning that it degrades proteins so what value does a protease have to your cardiovascular health for that we can turn to clot formation in your vessels so if we focus in on a plaque that has built up in your arteries and we assume that it's progressed quite a bit one thing that can happen is that the plaque generates clots why because when the cells that line your blood vessels called endothelial cells get pushed out of their normal linear configuration certain proteins get exposed like collagen and other extracellular proteins these aberant exposures lead to the activation of platelets which collect at the site of exposure this then leads to the formation of a clot as the platelets are then tied together with a protein called fibrin which is kind of a a rope likee protein across the entire clot unfortunately because of the sheer forces of blood flow on the clot which is not secure anyway the clot can then break off and float down to finer smaller blood vessels and block them causing a condition called esia so think of like a stroke now to be clear there are other ways of triggering clot formation but we'll ride with this example so ninas fits in in its primary mechanism by binding to and degrading fibin which is that protein that keeps the platelets together in doing so fibrin breaks and like a ripped bag of balls the platelets can then be dispersed individually instead of staying stuck together in a dangerous clot now there are other mechanisms described like supporting the presence of another enzyme that is also responsible for degrading fibrin called plasmin uh there's some chatter that it may reduce lipoprotein oxidation so it may also reduce inflammation and you know a few other things but I'll leave those mechanisms for my full analysis on the topic wherein I open all the studies for you and show you the data I'll link it to this video the main point being that it has a primary mechanism but the mechanistic research lends itself very poorly to translating to actual clinical measures so to get a look at nasis actual heart health effects we need to open some clinical studies okay I know you're here for the plaque reversing effects but why not kill three birds with one stone let me quickly describe what ninas does to your blood pressure and one other area of heart health as well on the blood pressure front we can lean on these studies and if we open them we can look at the data and we can see that while both groups did experience a drop in blood pressure me that sweet sweet placebo effect the Naas did experience a further Improvement interestingly that was corroborated by another study and not corroborated by another two studies creating this even split so why is that my guess is that the study data that we just went over was in people with high blood pressure including the corroborating study and the other two dissenting studies were in normotensive of individuals so I'll have more to say on this a little bit later another typically considered heart disease risk factor is lipoprotein burden the particles that carry cholesterol and triglycerides across your body if they're too abundant they're expected to raise heart disease risk unfortunately ninus does not seem to have an effect across all these studies except in one instance but this is a special study and it's actually the C pause for why this video title has the part about biased science real quick let me show you the lipoprotein data so that you know that I'm not just you know straight up lying to you clearly the data is extremely similar between Placebo and ninas and again without going through every study the results are consistent across the other trials then again why would we expect naoky supplementation to help in that regard remember I briefly mentioned that the mechanisms are reduced lipoprotein oxidation but not on total particle number so I think this is kind of has low odds of showing an effect anyway it's just the wrong experiment to run but let's move on to the main event the one you've been waiting for the one that you paid a hefty ticket price for you did watch the ads right really you skip them well okay I do me a solid and watch this one I'll keep this short I have a membership platform where I upload all of my analyses including applicable takeaways a monthly podcast and much more and it's designed to maximize your health while allowing me to continue doing this kind of work for you it's called the physionic Insiders and it's linked in the description of this video if you want to support me while also improving your own health then consider joining also the moment that I mentioned an ad was coming up guess what a lot of people did they they skipped ahead so as a little bonus for sticking it out with me through this self-sponsored ad I'll let you in a little secret that might give you a laugh later on later in this video I'm going to be referencing to a high does nines and a low do ninas and the people that skipped the ad will comment all frustrated about the what's the high dose and what's the low dose and I'm only going to tell you now the high dose is almost 11,000 fibrinolytic units or Fus and the low do is 2,000 Fus as a matter of fact I'm going to edit in the physionic Insiders Banner while I'm telling you this important information so that anyone who scrubs through will think that we're still talking about the Insiders which by the way I would still love for you to join I also cover much more on nookin there and I promise it's worth it and thank you I mean this kind of work takes me months so thank you for watching it through okay reversing atherosclerosis here's how we'll do things I'll show you the data as I promised I would but there's two arguments to be made on if ninas actually reverses atherosclerosis or not one says yes one says no which will you choose and for those confused don't worry I'll package things up for you at the end argument one ninas does not reverse atherosclerosis in one study the researchers gave ninas to participants for 3 years and then measured the pre-supplementation values against the postsupplementation values of atherosclerosis progression they showed compared against Placebo no difference indicating ninas did not reverse artherosclerosis however the researchers used a typical dose which is often considered a low dose and the participants only had slightly elevated heart disease risk so is it possible that the researchers used too low of a dose possible yes and that's where the pr noty study comes in argument two ninas does reverse atherosclerosis in another study the partipants consumed a high dose of ninas and when the researchers measured the pre versus post atherosclerosis measures as seen here we can see based on the experiment there is at least a 21% reversal of atherosclerosis by measure of cored artery into M media thickness that's just over one year too now while the results are impressive this study has issues for example it doesn't have a control group which is important in science additionally people are often concerned about conflicts of interest interest some of the researchers were employees of Industry companies that said is it possible that the biggest difference is the dosing the small dose has no effect and the large dose has an effect that's entirely possible so where do you land do you think that nines is effective or not for reversing atherosclerosis let me put forward my two sents including what I promised in regard to blood pressure and lipoprotein effects across all nine stud my impression of ninas for the metrics that we've looked at is that it has mild to No Effects if you go back to the blood pressure effects for example notice the difference is actually only a few points it still has an effect but there are likely more potent supplements and certainly habits that would outperform on the lipoprotein front again which every other study showed no effect the one study with no placebo group did show about a 15% reduction which is actually pretty impressive All Things Considered and while there are only two studies on reversing atherosclerosis one study is designed better but uses a low dose and the other study is designed poorly But it includes a higher dose essentially it boils down to this do you believe the one study showing all these positive effects even with its flaws and believe that dosing is the key to success or do you believe believe that all the other better controlled studies that show mild effects if that but use potentially too low of doses no matter what nin seems to be a net benefit based on the available literature so it might be worth a shot regardless but the exact magnitude of that benefit is in question however there is research looking at atherosclerosis reversal and guess what it's linked for you right here I'll speak with you there bye [Music] [Music]