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AI in Patient Portal Messaging: Risks and Opportunities

May 24, 2025

Opportunities and Risks of AI in Patient Portal Messaging in Primary Care

Introduction

  • Increased adoption of patient portals and telemedicine post-pandemic has resulted in a surge in patient portal messaging.
  • Primary care physicians (PCPs) face increased workloads due to electronic health record (EHR) tasks, leading to burnout.
  • Strategies to manage inbox overload have had limited success, including message length limits, billing for messages, and limiting message exchanges.
  • Generative AI, using large language models (LLMs), is being explored to draft automatic message responses to reduce workload.
  • Early results indicate a reduction in cognitive burden but no significant time reductions.
  • Risks include LLMs introducing inaccurate or inappropriate information, possibly affecting patient safety.

Study Objectives

  • Primary Objective: Determine how PCPs address errors in AI-generated draft responses.
  • Secondary Objective: Assess PCP perspectives on AI-generated responses.

Results

  • Study involved 20 participants, mostly female attending physicians with an average of 14.75 years post-medical school.
  • Participants missed correcting errors in AI drafts frequently, with a high likelihood of errors reaching patients.

Survey Responses

  • Participants held favorable views of AI drafts, reporting reduced cognitive workload and trust in AI tools.

Discussion

  • AI-generated drafts can pose safety risks due to hallucinations and outdated information.
  • Current AI implementations in healthcare outpace understanding of their safety.
  • Low rates of error detection by PCPs in AI drafts raise safety concerns.
  • Possible cognitive biases affecting error detection include functional fixedness, confirmation bias, automation complacency, and automation bias.
  • Recommendations include design improvements, technological advancements, and human review guidelines.

Limitations

  • Lack of full patient records for participants.
  • Remote study setting may have introduced distractions.
  • No control group for error rate comparison without AI assistance.
  • Limited diversity of message content covered.
  • Use of non-validated survey instruments.

Methods

  • Study approved by MedStar Health IRB; informed consent obtained.
  • Participants responded to 18 PPMs with AI-generated drafts in a simulated environment.
  • AI drafts reviewed by experienced PCPs to identify errors.

Data and Code Availability

  • Datasets and analysis code available upon request from the corresponding author.

Conclusions

  • AI drafts offer benefits in reducing cognitive load but present significant safety concerns.
  • A need for further research into AI error types, cognitive biases, and effective integration into clinical practice.