Lecture Notes: Acetaminophen (Paracetamol/Tylenol)

Introduction

• Acetaminophen, also known as paracetamol, is commonly referred to by its trade name, Tylenol.
• Important for exams like NCLEX: Focus on the generic name, Acetaminophen.

Clinical Uses

• Pain Relief
  • Symbolized by a splinter and band-aids.
  • Used for minor pain control.
  • Suitable for patients who can't take NSAIDs or opioids.
• Fever Reduction
  • Symbolized by the thermometer and high body temperature.
  • Acetaminophen has antipyretic (fever-reducing) properties.

Side Effects

• Hepatotoxicity (Liver Damage)
  • Symbolized by a liver-shaped lever.
  • Black box warning due to liver damage risk.
  • Concern for liver function especially in overdose scenarios.

Safety Guidelines

• Dosage
  • Do not exceed 4 grams (4G) per day.
  • Include all medications containing acetaminophen in total dose (e.g., Dayquil, Percocet).
  • Exceeding 4 grams can increase risk of hepatotoxicity.

Overdose Management

• Antidote: Acetylcysteine
  • Symbolized by 'Cysteine chapel'.
  • Administered to protect liver and reduce hepatotoxicity in overdose cases.

Recap

• Acetaminophen is used for pain and fever.
• Key side effect: Hepatotoxicity.
• Limit intake to under 4 grams daily.
• Acetylcysteine is an effective antidote in overdose situations.

Additional Resources

• Further resources include fact lists and interactive review images for deeper understanding.