GP2B3A Inhibitors: Key Facts for NCLEX

Introduction to GP2B3A Inhibitors

• Drug Class: Blood thinners
• Medications: Abciximab, Tyrophaban, Eptifibetide
• Function: Target and block glycoprotein 2B3A on platelets
  • Role of GP2B3A: Involved in platelet plug formation for blood clots

Memory Aids

• Mnemonic Device: Mario Kart Grand Prix on lap 2 out of 3 for GP2B3A
• Drug Name Mnemonics:
  • Abciximab: ABC blocks
  • Tyrophaban: Tyrannosaurus in Mario Kart
  • Eptifibetide: Epitaph for Eptifibetide

Mechanism of Action

• Action: Prevents platelet function by blocking their clumping
• Analogy: Paint thinner preventing clumpy paint
  • Relation to Drugs: Abciximab and others act as blood thinners

Clinical Uses

• Prevention of Clots:
  • During coronary artery stenting
  • In coronary emergencies (unstable angina, myocardial infarctions)

Side Effects

• Main Side Effect: Bleeding
  • Signs of Bleeding: Hypotension, tachycardia, tarry stools, blood in urine
  • Patient Care: Avoid invasive procedures; monitor hemoglobin and RBC levels

Conclusion

• Summary: GP2B3A inhibitors are antiplatelet agents used to prevent clots but can cause bleeding.
  • Monitoring: Keep track of CBC levels and signs of bleeding
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