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5 Natural Foods that Mimic Ozempic, a Weight Loss Drug

Jun 16, 2025

Overview

This episode explores five natural foods and food categories that can help mimic the effects of GLP-1 agonist weight loss drugs, such as Ozempic, with an emphasis on natural and holistic health strategies.

Context on GLP-1 Agonist Drugs

  • GLP-1 drugs like Ozempic are used for weight loss but may have significant side effects, including digestive problems.
  • Natural health philosophy suggests exhausting lifestyle and dietary options before considering medications.
  • GLP-1 (glucagon-like peptide 1) helps regulate blood sugar, inhibit glucagon, and acts as an appetite suppressant.

Food-Based Strategies to Mimic GLP-1 Effects

  • Extra Virgin Olive Oil: Rich in monounsaturated fats, mimics GLP-1 action, promotes satiation, cardiovascular health, and has anti-inflammatory properties; recommended dose is about 2 tablespoons once or twice daily.
  • Other Healthy Fats:
    • Avocado provides fiber, water, and healthy fats, supporting fullness.
    • Walnuts, macadamia nuts, and chia seeds (with Omega-3s and fiber) also contribute to satiety and blood sugar balance.
  • Proteins:
    • Eggs offer high satiety and mimic GLP-1 drug effects while providing choline and B vitamins.
    • Beans and legumes are recommended for plant-based eaters, supplying both protein and prebiotic fiber; increase intake gradually to avoid digestive issues.
  • Fermentable Fibers:
    • Oats and rye, containing beta-glucans, slow digestion and increase fullness (second meal effect), and improve gut health.
  • Berries:
    • Low in calories, high in fiber and water, and satisfy sweet cravings while promoting satiety and stabilizing blood sugar.

Bonus Recommendation

  • Apple Cider Vinegar: Raw variety helps balance blood sugar and supports digestion when consumed with protein-based meals; suggested dose is 1–2 tablespoons diluted in water at mealtime.

General Guidance

  • Prioritize natural interventions (nutrition, exercise, lab testing) before considering GLP-1 drugs.
  • Address metabolism, thyroid, adrenals, and blood sugar imbalances as root causes of weight issues.
  • Maintain awareness of caloric intake, particularly with calorie-dense options like olive oil.

Recommendations / Advice

  • Try natural, whole-food solutions for appetite and weight management before medications.
  • Run metabolic and hormone labs to identify underlying factors affecting weight.
  • Gradually introduce high-fiber foods to manage digestive comfort.
  • Use apple cider vinegar with meals (except fruit or smoothies) to aid digestion and blood sugar control.

Questions / Follow-Ups

  • Consider requesting future episodes on fermentable fibers or specific physiological mechanisms.
  • Submit comments with additional topic requests or questions about the protocols discussed.