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Understanding Wells Criteria for PE Assessment

May 20, 2025

Wells Criteria for Pulmonary Embolism

Purpose

  • Assess the risk of a patient having a pulmonary embolism (PE).
  • Determine next steps in diagnosis to rule in or rule out a PE.
  • Used to decide whether a D-dimer test or CT angiography (CTA) is necessary.

Importance

  • Essential in emergency room settings when immediate X-ray vision isn’t possible.
  • Not all patients can safely or cost-effectively have a CTA.
  • Relevant for exams like Step 2, Level 2, and internal medicine rotations.

Criteria Components and Scoring

  1. Clinical Signs of Deep Vein Thrombosis (DVT)

    • Presence of calf pain and tenderness.
    • Yes = 3 points, No = 0 points.
  2. Alternative Diagnosis Less Likely than PE

    • Subjective judgment if PE is the most likely diagnosis.
    • Yes = 3 points, No = 0 points.
  3. Heart Rate > 100 bpm

    • Can indicate a PE.
    • Yes = 1.5 points, No = 0 points.
  4. Recent Immobilization or Surgery

    • Immobilization in the past 72 hours or surgery in the last 4 weeks.
    • Yes = 1.5 points, No = 0 points.
  5. History of DVT or PE

    • Past history increases risk.
    • Yes = 1.5 points, No = 0 points.
  6. Hemoptysis

    • Coughing up blood.
    • Yes = 1 point, No = 0 points.
  7. Malignancy

    • Current or treatment within the past 6 months, or in palliative care.
    • Yes = 1 point, No = 0 points.

Interpretation and Next Steps

  • Score 0-4: PE Unlikely

    • Next step: D-dimer test (a simple blood test).
    • If D-dimer is positive, proceed to CTA.
  • Score 5 or Greater: PE Likely

    • Skip D-dimer and go directly to CTA.
    • Research shows >20% of patients with high Wells score confirmed PE via CTA.

Memorization Tips

  • "Angio" has 5 letters, thus a Wells score of 5 or more points directs to "Angio" (CTA).

Conclusion

  • Wells Criteria helps differentiate the diagnostic pathway for suspected PE.
  • Essential tool for clinical practice and exams to ensure the appropriate use of diagnostic resources.