TRT and Hormone Optimization Lecture Notes

Introduction

• Presenter: Steven De Vos
• Guest: Gil T.
• Topic: Basics of TRT (Testosterone Replacement Therapy) and understanding medical terminologies related to dosage calculations.

Key Concepts

Mass vs. Volume

• Dose Response: Often confused; many state volume instead of dose.
• Volume is the amount of fluid (e.g., cc or ml) whereas mass is the medication's concentration.
• Concentration Strength: Measured in mass per volume (e.g., mg/ml).

Understanding Concentration

• Example: Testosterone Cypionate
  • Commonly used in the US.
  • Concentration: 200 mg/ml.
  • One ml of this includes 200 mg of testosterone.

Measurement Units

• CC and ML: Interchangeable (1 cc = 1 ml).
• Dosage Calculation Examples:
  • 1ml contains 200 mg.
  • 0.5ml contains 100 mg.
  • 0.25ml contains 50 mg.
• Correct Answer Format: State in mg (e.g. 50mg, 100mg) not in ml.

Insulin Syringes

• Syringes Sizes: 100, 50, or 30 units.
• Usage for TRT: 27 to 29-gauge syringes.
• Units to ML Conversion:
  • 100 units = 1 ml
  • 50 units = 0.5 ml
  • 25 units = 0.25 ml

Conversion of Measurement Units

Global Lab Variations

• Common Units:
  • USA: Nanograms per deciliter (ng/dL)
  • Europe: Nanomoles per liter (nmol/L)

Conversion Tips

• Use Google Calculator: For easy conversion between different measurement units.
• Example Conversion:
  • Nanograms per deciliter to picograms per milliliter (divide by 10).

LabCorp Reporting Error

• LabCorp reports free testosterone as "nanograms per deciliter" but sometimes mistakenly as "picograms per milliliter."
• This is a known issue and may cause confusion.

Conclusion

• Content Appreciation: Encouragement to like and subscribe for more information.
• Further Learning: Watch additional videos on TRT and hormone optimization for deeper understanding.