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What key information does Diffusion Weighted Imaging (DWI) provide in tumor assessment?
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DWI is crucial for differentiating between abscesses, cellular tumors, and infarcts.
What genetic markers distinguish oligodendrogliomas?
Oligodendrogliomas are characterized by IDH mutation coupled with 1p/19q co-deletion.
How are medulloblastomas classified according to molecular subtypes?
Medulloblastomas are divided into four subtypes: WNT, Sonic Hedgehog, Group 3, and Group 4.
Which mutations are often shared by Pilocytic Astrocytoma, Ganglioglioma, and PXAs?
These tumors often share the BRAF V600E mutation.
What imaging techniques are crucial for assessing CNS tumors according to Dr. Sunmi Cha?
Structural MRI (T1, T2, FLAIR, DWI, ADC, SWI, ASL perfusion imaging), Physiologic MRI, PET CT/PET MR, and Spectroscopy.
What is the significance of the UCSF 500 Gene panel in the context of CNS tumor classification?
The UCSF 500 Gene panel is used to identify specific molecular genetic markers that are critical for tumor classification and appropriate treatment planning.
What imaging features are associated with Sonic Hedgehog subtype of medulloblastomas?
Sonic Hedgehog subtype appears hemispheric with multi-nodular solid components.
What is the distinction between PFA and PFB subtypes of ependymomas?
PFA appears asymmetrically off midline and is more aggressive, while PFB is midline, ball-shaped, and has a better prognosis.
What distinguishes the WNT subtype of medulloblastomas?
The WNT subtype of medulloblastomas is off midline.
What mutation defines Diffuse Midline Glioma?
Diffuse Midline Glioma is defined by the H3 K27M mutation.
Why are molecular genetic markers central to the 2021 WHO CNS tumor classification?
Molecular genetic markers provide essential information for tumor classification and help in correlating imaging findings with neuropathology and neuromolecular genetics.
Describe the role of SWI in CNS tumor imaging.
Susceptibility Weighted Imaging (SWI) is essential for assessing blood products in CNS tumors.
What are the significant changes in the 2021 WHO CNS tumor classification compared to previous editions?
The 2021 WHO CNS tumor classification emphasizes the inclusion of molecular genetic markers, with MRI imaging on the cover, highlighting the importance of imaging.
What genetic marker is related to both Solitary Fibrous Tumor and Hemangio Pericytoma?
Both tumors are related by STAT6 nuclear expression.
How are molecular glioblastomas (IDH wild-type) characterized?
Molecular glioblastomas (IDH wild-type) are characterized by mutations in TERT promoter, EGFR amplification, Trisomy 7, and Monosomy 10.
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