Session 1.2 Notes

Introduction

• Continuation from Session 1.1
• Question addressed: Impact of vitamin intake and genetic factors on arterial calcification
  • Importance of sufficient nutrient intake despite genetic predispositions
  • Focus on Vitamin K and E intake

Antioxidants

Vitamin C

• Roles
  • Antioxidant
  • Immune system support
  • Collagen synthesis
  • Carnitine production for mitochondria
  • Neurotransmitter synthesis (dopamine, adrenaline, noradrenaline)
  • Iron absorption from plant sources
• Deficiency
  • Can lead to scurvy-like symptoms
  • Essential as humans cannot synthesize it
• Genetic Factors
  • SLC23A1 gene affects Vitamin C absorption
  • Genetic variations can impact Vitamin C levels significantly

Glutathione

• Characteristics
  • Master antioxidant
  • Tripeptide (cysteine, glutamate, glycine)
  • Exists in reduced (active) and oxidized (inactive) forms
• Functions
  • Antioxidant reactivation
  • Toxin conjugation
  • Reactive oxygen species deactivation
• Synthesis
  • Requires amino acids, ATP, and various co-factors
  • Influenced by paracetamol intake

Genetic Impact on Antioxidants

• GST Family
  • Genes involved in detoxification
  • GSTM1, GSTP1, GSTT1 are part of this family
  • Whole gene deletions (nulls) can occur, affecting detoxification ability
  • High polymorphism in these genes
• Support Mechanisms
  • Nutritional and lifestyle adjustments can mitigate genetic deficiencies
  • Use of phytonutrients, exercise, and liver support

Antioxidant Cascades

• Interconnected role of antioxidants (Vitamin E, C, B3)
• Importance of balanced antioxidant levels to prevent oxidative stress

Key Takeaways

• Genetic predispositions can impact nutrient requirements
• Importance of holistic approach considering genetics, lifestyle, and environmental factors
• Genetic reports should be used in context with individual lifestyle for best outcomes

Additional Resources

• Website resources for reports and training
• In-person event for further learning

Conclusion

• Questions and answers session
• Acknowledgments to contributing members and reminders for future sessions