Nefiracetam Overview

Introduction

David Toman discusses Nefiracetam, a nootropic:

• Author of nootropics expert.com
• Topics covered: what it is, usage, science, dosage, and side effects.

What is Nefiracetam?

• Member of the racetam family of nootropics.
• Fat-soluble, unlike water-soluble piracetam.
• Affects acetylcholine levels in the brain.
• Used as a prescription drug in Japan.
• Available OTC in the USA, but not as a dietary supplement.
• Known for cognitive enhancement and anti-anxiety effects.

Development

• Developed by Daito Pharmaceutical in Japan in the late 1990s as a derivative of piracetam.

Mechanism of Action

• Enhances attention span, alertness, cognition, learning, and memory.
• More potent than piracetam.
• Neuroprotective qualities.
• Reduces anxiety and depression.

Calcium Channels and Memory Formation

• Increases the duration calcium channels remain open.
• Enhances protein kinase signaling critical for long-term potentiation (LTP) and memory formation.
• Potentiates acetylcholine receptors in the hippocampus, encouraging glutamate release.

Research Studies

• Studies show enhancement of memory retention and relearning in older rabbits.
• Significant effects last beyond supplementation period.
• Alters GABA signaling for mood stabilization.
• In mice, antidepressant effects observed within a day of supplementation.

Supplementation Tips

• Recommended dosage: 100 to 900 mg per day, divided doses.
• Take with a meal containing healthy fats for better absorption.
• Stack with choline sources (e.g., Alpha GPC, CDP Choline) to avoid headaches.

Benefits Reported by Users

• Improved attention span, motivation, visual acuity, and cognitive clarity.
• Users report enhanced mood, better verbal articulation, and reduced apathy.

Side Effects

• Generally considered safe and well-tolerated.
• Possible side effects: anxiety, fatigue, headaches, nervousness, and nausea—often due to high doses or lack of choline.

Safety and Toxicity

• Non-toxic at recommended doses.
• Prolonged use shows no toxic effects.
• High doses in animal studies led to issues not observed in humans.

Conclusion

• Nefiracetam appears to be a more effective memory enhancer than piracetam.
• For detailed studies, visit nootropics expert.com and search for Nefiracetam.
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