[Music] I'm David Tillman author of nootropics expert calm in this video I'm going to share with you what I know about Nefer acid to him is a nootropic what it is why we use it the science behind it dosage and side effects nefi racetam is arrest in the racetam family of nootropic compounds it's a fat-soluble inotropic the racetam class of nootropics have a perilla Doan nucleus at their core and never acid Hamza call an urgent compound meaning it affects acetylcholine levels in the brain Nephi racetam is used as a prescription drug in Japan and it's sold as an over-the-counter unrestricted compound in the United States but not as a dietary supplement one of the most recent synthetic nootropic compounds it is known as a cognitive enhancer and is known for its anxiolytic or anti-anxiety effects never racetam is considered to be more potent in porosity and as a nootropic it helps increase attention span alertness cognition learning and boost memory japanese based pharmaceutical company dachi sai aku developed never asset em in the late 1990s as a derivative of piracetam never racetam is fat soluble while piracetam is water-soluble fat soluble molecules cross the blood-brain barrier more easily than water soluble molecules both nefer-as item and porosity are cognitive enhancers and both have neuroprotective qualities both rice atoms are able to improve learning and memory and both are able to prevent brain damage Nefer asset m has additional benefits not shared with piracy jam nefra racetam can reduce anxiety and depression and exhibits several other memory enhancing qualities over piracetam fo racetam increases the amount of time calcium channels and neurons remain open tied to protein kinase a and the G alpha subunit protein signaling isn't hat enhanced in the neuroreceptor independent of the synapse this calcium channel pathway is critical for long-term potentiation in the formation of long term memories never racetam also potentiates protein kinase C alpha which is involved in long-term potentiation pkc a is dependent on glutamate signalling and nappa racetam activates CA MK 2 which is protein and it's critical for memory formation it's mainly dependent on glue at glutamate signaling and finally Nefer asset M potentiates acetylcholine receptors in the hippocampus which encourages glutamate release in long-term potentiation piracetam does not share this memory enhancing quality the bottom line is never a so Tim seems to be a much more potent memory enhancer than the original nootropic piracetam well first never racetam enhances memory in several studies and clinical trials researchers have noted nefer-as items empty amnesia effects and they've arrived at this observation by noting never never racetam interacting with individual acetylcholine receptors in the brain one study conducted at Albert Einstein healthcare network at Philadelphia worked with older rabbits researchers used a technique called nikka tating membrane eyeblink response in rabbits which is used in the lab to study age-related memory disorders in this case the team used never racetam to studies effect on retention and relearning the scientists administered 5 10 or 15 milligrams per kilogram of never racetam 234 retired rabbits I'm not sure what they were tired from but these were retired rabbits over 45 days and then tested retention and learn relearning 1/5 in twelve weeks post training the researchers found that the effect of Nefer racetam on the ability of older rabbits to relearn was apparent up to five weeks after using never as a team in other words never asset him has had a significant effect on memory long after the rabbit stopped using it the researchers concluded that never asset him likely has an even greater effect on memory the longer you use it this testing model is dependent on call energic or acetylcholine firing in the brain in the second way never racetam alleviates depression never racetam enhances the signaling of gaba on gaba receptors when gaba is low and has a suppressive effect when gaba is too high leading to stabilize mood and sociability no mood swings never aciton also produces an antidepressant effect activating the enzyme see a mk2 which we mentioned before the scientists in Japan worked with mice with depressive like behaviors the mice were given one milligram per kilogram per day of never aciton and noticed antidepressant effects within a day of supplementation now note that this antidepressant effect takes a completely different approach to controlling depression compared to SSRIs these prescription antidepressants mess with serotonin levels in your brain to control depression and come with a host of side effects also note that the ca mk2 enzyme is associated with long term memory formation never racetam modulates gaba in your brain gaba is the primary inhibitory neurotransmitter in the brain its role is to clean keep glutamate the primary excitatory neurotransmitter from overwhelming your brain and causing damage when GABA levels are too low you experience anxiety insomnia poor mood and restlessness and if it's left unchecked it can lead to neurodegenerative disease in a very poor quality of life but when gaba is too high you have a toxic a given environment in your brain causing damage to neurons and other areas of your brain now a racetam modulates GABA levels keeping them steady for a healthy brain an improved long-term memory never racetam contributes to learning by enhancing long-term potentiation or LTP enhancing NMDA dependent LTP at low concentrations and AMPA dependent LTP at higher concentrations nefra racetam combined with choline boosts the production of the crucial to our neural transmitter acetylcholine improving memory recall and focus never racetam is fat soluble and quickly enters your brain after you take it once in your brain at boost signal transmission and protects neurons never acid ham boosts acetylcholine so you should use it with a good cooling source you can try alpha GPC or CDP cooling with never racetam and give your brain the cooling that it needs several studies have noted that short-term or one-time use of never a satyam doesn't do too much but supplementing Nefer racetam every day for seven days or more is needed to experience the full benefit of this new tropic now this is what new nootropics users report now a racetam is a study aid Nefer asset amp produces calm focus recall and cognition for many neural hackers it improves attention span motivation and alleviates apathy and mental fatigue increased visual acuity the visual effects of nappa racetam feel like your brain is processing processing a broader spectrum of whatever's in your visual range nature and your surroundings look more vibrant and beautiful and mood many users report a calm focus and being able to articulate thoughts and improve speaking ability language and your vocabulary seem to flow effortlessly thoughts come with much less effort some experienced users of aniracetam say they prefer never acid to him now you may recall that the chemical structure of never rise to TM is very similar to a aniracetam and the clinical studies support the superior ability to boost memory you should be able to experience the full effects of never racetam within seven days of starting to supplement with it it's fat soluble so it digests and enters your cells quickly never racetam was developed by a company in Japan in the late 1990s as a result the majority of the published research available in Western directories was conducted in Japan and most of it on rats and mice clinical trials for never a Satyam have been conducted in China and the USA for use on treating Alzheimer's disease so far no large pharmaceutical company in the USA has formulated a prescription drug version of never SOT I'm not as far as I know now if you'd like to see more detailed Studies on fo racetam go to nootropics expert comm and search for it in Fr asset M or click on the link below this video I've got clinical studies therefore never asset M as an antidepressant never asset m and how it improves learning and memory I've got another study on how nepo racetam reduces apathy so to check out these clinical studies in more detail go to nootropics expert and search for never racetam recommended Newton fo racetam dosage is 100 to 900 milligrams per day taken and divided doses one never racetam dose in the morning and one in the early afternoon Nefer racetam is sold in tablet capsule and powder form tablet and capsules are usually 400 to 600 milligrams each now since nepo racetam is a fat-soluble nootropic you should take it with a meal containing healthy fats or with a tablespoon of extra-virgin expeller cold-pressed coconut or olive oil or other similar healthy fact just to ensure quick absorption nefra racetam also boosts seta colon activity in your brain to avoid a racetam headache make sure that you stack Nefera racetam with a good choline source like CDP cooling or alpha GPC and please note that most studies suggest in many neuro hackers report that it will take at least seven days of daily dosing of Nefer acid him to experience the full benefit of this new tropic don't take it once and expect it to see good results never racetam is non-toxic so is considered well tolerated and safe side effects are rare but can include anxiety fatigue headaches nervousness and nausea side effects are often a result of using unusually high doses of this nootropic headaches from using that veracity M typically happen when you forget to combine it with a good choline supplement headaches are often a symptom of a choline deficit in your brain and nearly all of the toxicity studies on never asitane have been done on animals in prolonged usage of this nootropic have shown no toxic effects at the recommended doses now one study with male beagle dogs reported a reduction in testicular testosterone after a single treatment of never acid him but before guys before you write this new tropic off note that the dose was a ridiculous a 180 or 300 milligrams per kilogram of weight that's the equivalent of 16 to 27 grams of nappa racetam for a 200-pound male human and dogs happen to metabolize napa racetam different than humans and primates the metabolite m18 in dogs seems to be the culprit and is not found in humans or monkeys now I'm not going to belabor this point but just to say that nappa racetam is safe and non-toxic if used it recommended doses just please don't give it to your dog never racetam is sold in tablet capsule and powder form tablets and capsules are usually 400 to 600 milligrams each so my nootropics expert recommendation for Nefer racetam is 100 to 900 milligrams per day and that's my report on fo racetam if you want to see links to the studies I talked about go to nootropics expert comm and search for never racetam or click on the link below this video there you'll find a full transcript to this video and you'll find dozens of articles and all the well-known nootropics over on the tropics expert if you have any questions or you want to share your experience using nefra racetam please use the comments section at the bottom of the post over on nootropics expert i respond to comments and questions at nootropics expert you'd be the same day if you want to see more videos in all the best nootropics used today subscribe to this channel before you leave I'll be putting up new videos on the tropics and optimizing your brain every week I'm David Toman author of nootropics expert